Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 68
Filter
1.
Surg Today ; 52(8): 1153-1159, 2022 Aug.
Article in English | MEDLINE | ID: mdl-34982227

ABSTRACT

PURPOSE: A nationwide survey was conducted to investigate the current status of pediatric gastroesophageal reflux disease (GERD) in Japan, with special reference to the characteristics of intractable GERD. METHODS: Data were collected using a questionnaire from facilities specializing in the treatment of pediatric GERD in Japan. Intractable GERD was defined as follows: I, no symptomatic improvement after 8 weeks of optimal medical treatment (OMT) plus fundoplication; II, no symptomatic improvement after 8 weeks of OMT and with no indications for fundoplication; and III, no symptomatic improvement after surgery without OMT. RESULTS: We collected data from 3,463 pediatric patients with GERD from 91 institutions, and 81 satisfied the definition of intractable GERD. Additional clinical information was obtained from 56 patients, and 41 represented cases of definite intractable GERD. The main underlying disorders included neurological impairment (NI), esophageal atresia (EA), and congenital heart disease (CHD), which altogether accounted for 85% of patients. Of the 41 patients, 33 received fundoplication, and the remaining 8 received medical treatment alone because surgery was considered unsuitable. CONCLUSIONS: The nationwide survey revealed that pediatric intractable GERD is rare in Japan. Three main underlying disorders-NI, EA, and CHD-were implicated in the majority of cases of intractable GERD.


Subject(s)
Esophageal Atresia , Gastroesophageal Reflux , Heart Defects, Congenital , Laparoscopy , Child , Esophageal Atresia/surgery , Fundoplication , Gastroesophageal Reflux/surgery , Gastroesophageal Reflux/therapy , Heart Defects, Congenital/surgery , Humans , Japan/epidemiology , Surveys and Questionnaires , Treatment Outcome
2.
Clin Nutr ESPEN ; 42: 180-187, 2021 04.
Article in English | MEDLINE | ID: mdl-33745575

ABSTRACT

BACKGROUND & AIMS: Nutritional metabolism is complex in pediatric patients with severe motor and intellectual disability (SMID), and therefore, appropriate estimation of the energy requirements is difficult. Focusing on ghrelin's role in energy metabolism regulation, we investigated plasma ghrelin levels in pediatric SMID patients and analyzed its nutritional significance as a regulatory marker of energy reserve. METHODS: Fasting plasma total, acyl, and des-acyl ghrelin levels in 40 patients with SMID, including cerebral palsy (CP) (n = 20) and muscular disease (MD) (n = 8), and healthy controls (n = 13) were investigated. The correlations of plasma ghrelin levels with anthropometry, blood nutritional markers, energy intake, and resting energy expenditure (REE) measured with indirect calorimetry were analyzed. A p value < 0.05 was considered significant. RESULTS: SMID patients had significantly higher acyl ghrelin, and lower body mass index (BMI), z-scores of body weight (BW), body height and BMI, and albumin than controls. CP patients had significantly higher total and acyl ghrelin, z-score of the mid-upper arm circumference (MUAC), retinol-binding protein, transthyretin, creatinine, and glucose than MD patients. Total and acyl ghrelin in CP patients and des-acyl ghrelin in MD patients had significant negative correlations with MUAC and upper arm fat area. In CP patients, total and acyl ghrelin had significant positive correlations with REE/BW (kcal/kg), and total ghrelin was predictive of REE/BW (r2 = 0.625, p < 0.0001). CONCLUSIONS: An increase in acyl ghrelin observed in SMID patients possibly indicates energy reserve deficiency. In CP patients, total and acyl ghrelin inversely reflected total body fat mass, resulting in strongly positive correlations with REE/BW. The measurement of plasma ghrelin may be useful to assess nutritional metabolism and energy reserve in pediatric SMID patients, such as CP and MD patients.


Subject(s)
Ghrelin , Intellectual Disability , Anthropometry , Calorimetry, Indirect , Child , Energy Metabolism , Humans
3.
Surg Today ; 50(7): 664-671, 2020 Jul.
Article in English | MEDLINE | ID: mdl-31214780

ABSTRACT

Multichannel intraluminal impedance-pH measurements (MII-pH) are useful for evaluating acid and non-acid gastroesophageal reflux (GER). However, the use of MIH-pH is not yet established in Japan. The Japanese Pediatric Impedance Working Group (Japanese-PIG) convened to devise a standard protocol for MII-pH in Japanese children. The expert members of the Japanese-PIG collected data on pediatric MII-pH from the relevant literature in English, including the standard protocol of MII-pH presented by the European PIG, and the insights of international experts. The resultant consensus was included in the contents of the standard protocol of MII-pH. The standard protocol included standardization of the indication, methodology, and interpretation of MII-pH in Japanese children. The criteria for abnormal GER by MII-pH were defined using the Reflux Index and number of total reflux episodes independently in children aged < 1 year and those aged ≥ 1 year. Moreover, a significant relationship between GER and symptoms was identified using the symptom index and symptom association probability approach. We conclude that the current version of the protocol for MII-pH is tentative because it is not based on data from Japanese children. Further studies are needed to render this protocol clinically beneficial and expand its use in Japan.


Subject(s)
Electric Impedance , Esophageal pH Monitoring/methods , Esophageal pH Monitoring/standards , Gastroenterology/organization & administration , Gastroesophageal Reflux/diagnosis , Gastroesophageal Reflux/physiopathology , Hydrogen-Ion Concentration , Pediatrics/organization & administration , Societies, Medical/organization & administration , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Japan , Male , Young Adult
4.
Surg Today ; 50(7): 672, 2020 Jul.
Article in English | MEDLINE | ID: mdl-31713689

ABSTRACT

The authors would like to add the following sentence in Acknowledgements in the original publication of this paper.

5.
J Pediatr Surg ; 54(12): 2546-2549, 2019 Dec.
Article in English | MEDLINE | ID: mdl-31727384

ABSTRACT

BACKGROUND/AIM: Although the mucosectomy-commencing points on transanal endorectal pull-through (TAEPT) differ among reports, the optimal point is unclear. This study assessed the outcomes among different mucosectomy-commencing points. METHODS: We conducted a nationwide survey from 2008 to 2012. The data of 1,087 Hirschsprung's disease patients were collected, and data on those who underwent TAEPT were extracted. The patients were divided according to the mucosectomy-commencing points into two groups: in Group A, mucosectomy was started ≥5 mm from the dentate line (DL), and in Group B, mucosectomy was started <5 mm from the DL. The extent of the aganglionic segment and postoperative complications in the month after TAEPT were compared. RESULTS: The data of 327 patients were extracted (Group A, n=155; B, n=172). Aganglionosis extending to the sigmoid colon was the most frequent in both groups. Regarding postoperative complications, the patients of each group experienced enterocolitis (Group A: 8.4%; B: 7.6%) and incontinence (A: 3.9%; B: 2.9%). The incidence of rectal mucosal prolapse was significantly greater in Group B (4.1%); (A: 0%, p=0.02). CONCLUSIONS: Although the outcomes of TAEPT were comparable in both groups, rectal mucosal prolapse was significantly frequent in patients in whom the commencing point was <5 mm from the DL. TYPE OF STUDY: Retrospective study LEVEL OF EVIDENCE: Level III.


Subject(s)
Hirschsprung Disease/surgery , Intestinal Mucosa/surgery , Postoperative Complications/etiology , Adolescent , Adult , Child , Child, Preschool , Digestive System Surgical Procedures/adverse effects , Digestive System Surgical Procedures/methods , Enterocolitis/etiology , Fecal Incontinence/etiology , Humans , Infant , Infant, Newborn , Japan , Middle Aged , Rectal Prolapse/etiology , Retrospective Studies , Surveys and Questionnaires , Young Adult
6.
Pediatr Surg Int ; 35(5): 547-550, 2019 May.
Article in English | MEDLINE | ID: mdl-30847604

ABSTRACT

PURPOSE: Hirschsprung's disease-related short bowel syndrome (HDSBS) is characterized by aganglionosis that extends orally to 75 cm from Treitz's band. The condition is reported be associated with a high mortality rate of 50-80%. This retrospective study aimed to survey the current trends in HDSBS treatment in Japan. METHODS: Patient data were extracted from the results of a nationwide survey we conducted, resulting in the retrospective collection of the data of 1087 HD patients from 2008 to 2012 in Japan. RESULTS: A total of 11 (0.9%) cases of HDSBS were noted. All patients underwent jejunostomy as neonates. Radical procedures performed in five patients (A-colon patch method in four, Duhamel's procedure in one). Ziegler's myotomy-myectomy and serial transverse enteroplasty (STEP) were performed in each patient as palliative procedures. No radical operations were performed in 4 of the 11 cases. The mortality rate was 36.4%. Four patients died, 1 patient who underwent STEP and 3 patients who received no radical procedures. The causes of death were sepsis due to enterocolitis or central intravenous catheter infection, and hepatic failure. All patients who underwent radical procedures survived and showed satisfactory outcomes. CONCLUSION: HDSBS still showed a high mortality rate, although surgical approaches such as the A-colon patch method resulted in satisfactory outcomes.


Subject(s)
Health Surveys/statistics & numerical data , Hirschsprung Disease/complications , Hirschsprung Disease/surgery , Short Bowel Syndrome/etiology , Short Bowel Syndrome/surgery , Female , Humans , Infant , Infant, Newborn , Japan , Male , Retrospective Studies , Treatment Outcome
7.
Surg Today ; 48(2): 175-179, 2018 Feb.
Article in English | MEDLINE | ID: mdl-28710555

ABSTRACT

PURPOSE: Goreisan, a traditional Japanese medicine, has previously been used for hydrostatic modulation. This retrospective study investigated the efficacy of goreisan for spermatic cord hydrocele resolution in children. METHODS: Seventy-two boys treated for spermatic cord hydrocele between 2012 and 2015 were included; Goreisan was administered to 16 [group G, median age 3 (1-8) years], and 56 were followed without medication [group C, median age 1 (0-8) years]. An age-matched comparison was conducted between 14/16 group G patients (group g) and 14/56 group C patients (group c). RESULTS: Incidences of resolution were higher in groups G and g than in groups C and c, respectively, both during the study period and within the first 6-month observation period; groups G and g also had a significantly lower incidence of surgery for hydrocele than in groups C and c, respectively. The interval from the commencement of observation until hydrocele resolution was significantly shorter in group G than in group C, but not in group g than in group c. CONCLUSION: Goreisan can effectively promote the resolution of spermatic cord hydrocele in children and may be a valid treatment choice for this condition.


Subject(s)
Drugs, Chinese Herbal/administration & dosage , Phytotherapy , Spermatic Cord , Testicular Hydrocele/drug therapy , Age Factors , Child , Child, Preschool , Humans , Incidence , Infant , Male , Medicine, Kampo , Retrospective Studies , Testicular Hydrocele/surgery , Treatment Outcome , Urologic Surgical Procedures, Male/statistics & numerical data
8.
Pediatr Surg Int ; 33(10): 1073-1079, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28808763

ABSTRACT

PURPOSE: To clarify the characteristics of gastroesophageal reflux (GER) in pediatric patients with neurological impairment (NI). METHODS: Twenty-six patients with NI, 1-17-year-old, fed via a nasogastric tube were categorized based on the absence (group I) or presence (group II) of abnormal GER, defined with multichannel intraluminal impedance-pH monitoring as %time with an esophageal pH <4.0 being ≥5.0% or number of liquid/mixed bolus reflux events(RE) >70 in 24 h. RESULTS: %Time and number of distal and proximal bolus REs were not significantly different between acid and nonacid REs. %Time of acid bolus RE and that of acid and total number of distal and proximal bolus REs were significantly higher in group II than in group I. Mean acid clearance time was significantly longer in group II. Median bolus clearance time was similar between the groups. No bolus RE parameters were significantly different between acid and nonacid REs in group I. Acid bolus RE was significantly higher than nonacid RE in terms of %time and number of proximal bolus RE in group II. CONCLUSION: Acid REs significantly increased in pediatric patients with NI with abnormal GER. The number of acid and nonacid REs was comparable in patients without abnormal GER.


Subject(s)
Gastroesophageal Reflux/complications , Nervous System Diseases/complications , Adolescent , Child , Child, Preschool , Female , Humans , Hydrogen-Ion Concentration , Infant , Intubation, Gastrointestinal , Male , Retrospective Studies
9.
J Pediatr Surg ; 50(12): 2009-11, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26590474

ABSTRACT

PURPOSE: The aim of this study was to evaluate the long-term outcomes of four patients with tracheal agenesis who underwent airway and esophageal/alimentary reconstruction. MATERIALS AND METHODS: We reviewed the medical records of four long-term survivors of tracheal agenesis and collected the following data: age, sex, type of tracheal agenesis, method of reconstruction, nutritional management, and physical and neurological development. RESULTS: The patients consisted of three boys and one girl, who ranged in age from 77 to 109months. The severity of their condition was classified as Floyd's type I (n=2), II (n=1), or III (n=1). Mechanical respiratory support was not necessary in any of the cases. Esophageal/alimentary reconstruction was performed using the small intestine (n=2), a gastric tube (n=1), and the esophagus (n=1). The age at esophageal reconstruction ranged from 41 to 55months. All of the cases required enteral nutrition via gastrostomy. Three of the patients were able to swallow a small amount of liquid and one was able to take pureed food orally. The physical development of the subjects was moderately delayed-borderline in childhood. Neurological development was normal in two cases and slightly delayed in two cases. CONCLUSIONS: None of the long-term survivors of tracheal agenesis required the use of an artificial respirator, and their development was close to normal. Future studies should aim to elucidate the optimal method for performing esophageal reconstruction to allow tracheal agenesis patients to achieve their full oral intake.


Subject(s)
Constriction, Pathologic/surgery , Esophagus/surgery , Plastic Surgery Procedures/methods , Trachea/abnormalities , Trachea/surgery , Child , Child, Preschool , Female , Follow-Up Studies , Humans , Male , Retrospective Studies , Treatment Outcome
10.
J Pediatr Surg ; 50(12): 2048-50, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26413901

ABSTRACT

BACKGROUND: Megacystis microcolon intestinal hypoperistalsis syndrome (MMIHS) is a rare condition with a poor outcome. A nationwide survey was conducted to identify the clinical features and outcomes of MMIHS in Japan. METHODS: Data were collected via a questionnaire, which was sent to 353 pediatric/pediatric surgical departments in Japan. RESULTS: Of the 28 patients registered as having a certain diagnosis of MMIHS, 19 (male/female, 3/16) patients were analyzed. All of the patients developed functional bowel obstruction in the neonatal period and showed a distended bladder and microcolon in the radiological examination. A histopathology assessment of the full-thickness of intestinal specimens showed no pathological abnormalities in all patients. Although various medications were given, the patients did not show significant improvement. Drainage stomas were created in the jejunum (n=11) and colon (n=5). Sixteen patients were maintained by parenteral nutrition (PN). Nine patients died of sepsis or liver failure. The five- and ten-year survival rates were 63% and 57%, respectively. CONCLUSIONS: MMIHS patients developed severe functional intestinal obstruction in the neonatal period and had no specific therapeutic intervention. The majority of MMIHS patients required long-term PN. Small bowel or multivisceral transplantation may be necessary to improve the outcome of this condition.


Subject(s)
Abnormalities, Multiple , Colon/abnormalities , Intestinal Pseudo-Obstruction , Urinary Bladder/abnormalities , Abnormalities, Multiple/diagnosis , Abnormalities, Multiple/mortality , Abnormalities, Multiple/physiopathology , Abnormalities, Multiple/therapy , Adolescent , Child , Child, Preschool , Colon/physiopathology , Female , Health Surveys , Humans , Infant , Infant, Newborn , Intestinal Pseudo-Obstruction/diagnosis , Intestinal Pseudo-Obstruction/mortality , Intestinal Pseudo-Obstruction/physiopathology , Intestinal Pseudo-Obstruction/therapy , Japan/epidemiology , Male , Surveys and Questionnaires , Survival Rate , Urinary Bladder/physiopathology , Young Adult
11.
J Pediatr Surg ; 50(12): 2019-24, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26413902

ABSTRACT

BACKGROUND: The purpose of this study was to investigate fetal cardiac ultrasonographic parameters in relation to the outcomes of patients with isolated left-sided congenital diaphragmatic hernia (CDH). METHODS: Subjects comprised 33 fetuses with fetal CDH and 99 control fetuses without cardiac and lung anomalies. Three parameters, cardiothoracic area ratio (CTAR), the ratio of the diameter of the main pulmonary artery to that of the ascending aorta (MPA/AAo), and the ratio of the diameter of the tricuspid valve to that of the mitral valve (TV/MV) were compared between fetal CDH and control subjects and between survival (SG) and non-survival (NSG) groups. RESULTS: All three parameters differed significantly between CDH and control fetuses. Significant differences between SG and NSG were observed in CTAR and TV/MV ratio, but not in MPA/AAo ratio before and after 32 gestational weeks. A significant increase in the TV/MV ratio was noted along with an increase in gestational age. A TV/MV ratio of >1.72 discriminated non-survivors from survivors with better sensitivity and specificity. CONCLUSIONS: Fetal cardiac ultrasonography provides useful information for predicting the outcomes of isolated left-sided CDH. The TV/MV ratio was considered a reliable indicator that reflected outcomes of isolated left-sided CDH.


Subject(s)
Fetal Heart/diagnostic imaging , Hernias, Diaphragmatic, Congenital/diagnostic imaging , Ultrasonography, Prenatal , Case-Control Studies , Female , Gestational Age , Hernias, Diaphragmatic, Congenital/mortality , Humans , Male , Pregnancy , Prognosis , Retrospective Studies , Sensitivity and Specificity
12.
Pediatr Surg Int ; 31(10): 917-23, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26276427

ABSTRACT

PURPOSE: To investigate the causal relationship between delayed gastric emptying (DGE) and gastroesophageal reflux (GER) in patients with neurological impairment (NI). METHODS: Subjects included 30 NI patients (age, 1-34 years; median, 6 years). Combined multichannel intraluminal impedance-pH (MII-pH) monitoring and (13)C-breath test evaluated acid/non-acid reflux episodes (RE) and gastric emptying rates, respectively. Values are shown with medians and ranges. RESULTS: Percentage time for esophageal pH < 4.0 (reflux index: RI) and numbers for total RE and RE > 5 min were 8.3 (0-35.7), 44 (0-129), and 5 (0-22), respectively. Total percentage time and bolus RE numbers were 1.4 (0.0-6.9) and 49 (2-159), respectively. Median bolus clearance time was 16 s (9-45). T 1/2, T lag, and GEC were 103 s (75-204), 54 s (18-97), and 3.4 (2.3-4.3), respectively. Gastric emptying rates and acid/non-acid reflux parameters were not significantly correlated, except T 1/2 correlated significantly with the numbers of RE > 5 min (p = 0.04). T 1/2 inversely correlated with bolus clearance time (p = 0.01). Reflux parameters between DGE and non-DGE patients were not significantly different, except median bolus clearance time was significantly shorter in DGE patients (p = 0.01). CONCLUSIONS: NI patients showed a wide range of gastric emptying rates without any significant causal relationship between DGE and GER.


Subject(s)
Gastroesophageal Reflux/complications , Gastroparesis/complications , Nervous System Diseases/complications , Adolescent , Adult , Child , Child, Preschool , Esophageal pH Monitoring , Female , Gastroparesis/diagnosis , Humans , Infant , Male , Young Adult
13.
Pediatr Int ; 57(4): 677-81, 2015 Aug.
Article in English | MEDLINE | ID: mdl-25728615

ABSTRACT

BACKGROUND: The aim of this study was to investigate factors associated with the development of parenteral nutrition-associated liver disease (PNALD) and to examine the clinicopathological relationship of PNALD in extremely low-birthweight infants (ELBWI). METHODS: The subjects were 13 ELBWI who had received PN because of intestinal perforation or functional ileus between 2000 and 2013. We measured the serum levels of biochemical parameters, including aspartate aminotransferase, alanine aminotransferase, and direct bilirubin. Liver histopathology was examined in relation to outcome. The subjects were categorized into two groups on liver histopathology: F(+), development of hepatic fibrosis and necrosis with/without cholestasis; and F(-), no hepatic fibrosis. RESULTS: Of 13 ELBWI, five died of hepatic failure, five died of sepsis, and the other three were alive at the time of the study. Of the five infants who died of hepatic failure, two developed fulminant hepatitis without cholestasis, and the other three developed chronic cholestasis and finally hepatic failure. Postmortem histopathology in F(+) indicated not only massive hepatic necrosis, but also massive hepatic fibrosis. These histopathological findings explained the clinical presentation of portal hypertension. There were significant differences in the fasting period after intestinal disease onset between the two groups. CONCLUSION: The prolonged fasting with PN is responsible for severe hepatocellular necrosis with fibrosis and consequent lethal portal hypertension.


Subject(s)
Infant, Extremely Low Birth Weight , Infant, Premature, Diseases/therapy , Intestinal Diseases/congenital , Liver Diseases/etiology , Parenteral Nutrition/adverse effects , Biopsy , Female , Follow-Up Studies , Humans , Infant , Infant Mortality/trends , Infant, Newborn , Infant, Premature, Diseases/diagnosis , Intestinal Diseases/therapy , Japan/epidemiology , Liver/pathology , Liver Diseases/diagnosis , Liver Diseases/epidemiology , Male , Retrospective Studies
14.
Pediatr Int ; 57(1): 161-3, 2015.
Article in English | MEDLINE | ID: mdl-25711255

ABSTRACT

Internal hernia through a mesenteric defect, called mesenteric hernia, is an uncommon cause of acute intestinal obstruction in newborns. Strangulated mesenteric hernia results in intestinal necrosis or perforation and progressive deterioration with fatal outcome, especially when it occurs in low-birthweight infants. We report two very low-birthweight (VLBW) infants, who presented with acute intestinal obstruction related to mesenteric defect. The initial diagnosis was meconium obstruction in those cases, which is a common cause of bowel obstruction occurring in VLBW infants. Correct diagnosis of mesenteric hernia was difficult in these cases because of rapid deterioration and non-specific radiological findings. Awareness of the possibility of rare mesenteric hernia causing acute intestinal obstruction and surgical intervention in an appropriate timeframe are important for rescuing VLBW infants with such organic abnormalities.


Subject(s)
Hernia/complications , Ileal Diseases/etiology , Infant, Newborn, Diseases , Infant, Very Low Birth Weight , Intestinal Obstruction/etiology , Mesentery , Fatal Outcome , Hernia/diagnosis , Humans , Ileal Diseases/diagnosis , Infant, Newborn , Intestinal Obstruction/diagnosis , Male
15.
Surg Today ; 45(7): 876-9, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25387655

ABSTRACT

PURPOSE: Our previous experimental study of perforated peritonitis in rats proved that peritoneal lavage with strong acid electrolyzed water (SAEW) has no adverse effects, reduces the bacteria count in the ascitic fluid more effectively than saline, and increases the survival rate significantly. Thus, we conducted a randomized controlled study, applying SAEW in the treatment of perforated appendicitis in children. METHODS: Forty-four patients, aged 3-14 years, were randomly divided into two groups: Group S (n = 20), in which the peritoneal cavity was lavaged with 100 ml/kg saline and the wound was washed out with 200 ml saline; and Group E (n = 24), in which the peritoneal cavity was lavaged with 100 ml/kg SAEW and the wound was washed out with 200 ml SAEW. RESULTS: No adverse effect of SAEW was observed in Group E. There was no difference in the bacterial evanescence ratio of ascitic fluid after lavage between Groups S and E (11.1 and 15.8%, respectively). A residual abscess developed in one patient from each group (5.0 and 4.2%, respectively). The incidence of surgical site infection (SSI) was significantly lower in Group E than in Group S (0 and 20%, respectively; P < 0.05). There was no difference in the duration of pyrexia, positive C-reactive protein, leukocytosis, or hospital stay between the groups. CONCLUSION: Peritoneal lavage and wound washing with SAEW have no adverse effects and are effective for preventing SSI.


Subject(s)
Anti-Infective Agents, Local/therapeutic use , Appendectomy , Appendicitis/surgery , Hydrogen Peroxide/therapeutic use , Peritoneal Lavage/methods , Surgical Wound Infection/prevention & control , Adolescent , Child , Child, Preschool , Female , Humans , Incidence , Male , Surgical Wound Infection/epidemiology , Treatment Outcome
16.
J Pediatr Surg ; 49(12): 1742-5, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25487474

ABSTRACT

BACKGROUND/PURPOSE: The purpose of this study was to retrospectively investigate whether laparoscopy-aided gastrostomy placement (LGP) improved or worsened gastroesophageal reflux (GER) in neurological impairment (NI) patients. METHODS: Subjects included 26 NI patients nourished via nasogastric tubes (age, 1-17years; median, 6years). They were divided into groups based on the percentage of time with an esophageal pH <4.0 (reflux index: RI) before LGP: Group 1 (GI, n=13), RI <5.0%; Group II (GH, n=13), RI ≥5.0%. Acid/nonacid reflux episodes (RE) were evaluated using combined pH-multichannel intraluminal impedance (pH-MII) monitoring, and gastric emptying was measured with the C breath test before and after LGP. RESULTS: RI and number of RE evaluated with pH analyses and number of total/acid distal and proximal bolus RE with pH-MH increased significantly in GI. RI and acid clearance time with pH analyses and number of total bolus RE with pH-MII decreased significantly in GH. Gastric emptying parameters did not change significantly in GI, whereas the half-gastric emptying time and gastric emptying coefficient improved significantly in GH. CONCLUSION: LGP reduces GER in NI patients with pathological GER by improving gastric emptying, although it has a paradoxical influence on those without pathological GER.


Subject(s)
Gastric Emptying/physiology , Gastroesophageal Reflux/surgery , Gastrostomy/methods , Laparoscopy/methods , Nervous System Diseases/complications , Adolescent , Child , Child, Preschool , Female , Gastroesophageal Reflux/complications , Gastroesophageal Reflux/physiopathology , Humans , Infant , Intubation, Gastrointestinal , Male , Nervous System Diseases/therapy , Retrospective Studies , Treatment Outcome
17.
J Pediatr Surg ; 49(12): 1799-803, 2014 Dec.
Article in English | MEDLINE | ID: mdl-25487487

ABSTRACT

BACKGROUND/PURPOSE: A nationwide survey was conducted to identify the clinical presentation of pediatric chronic intestinal pseudo-obstruction (CIPO) in Japan. METHODS: Data were collected via a questionnaire, ensuring patient anonymity, from facilities that treat pediatric gastrointestinal diseases in Japan. RESULTS: Ninety-two responses were collected from forty-seven facilities. Sixty-two patients (28 males, 34 females) met formal diagnostic criteria for CIPO. The estimated pediatric prevalence was 3.7 in 1 million individuals. More than half the children (56.5%) developed CIPO in the neonatal period. Full-thickness intestinal specimens were available for histopathology assessment in forty-five patients (72.6%). Forty-one (91.1%) had no pathological abnormalities and were considered to be idiopathic. Patients were treated according to the local protocol of each facility. Forty-one patients (66.1%) had restricted oral intake of ordinary diets, and twenty-nine (46.8%) depended on parenteral nutrition. No therapeutic intervention, including medication and surgery, successfully improved oral food intake or obstructive symptoms. Only three patients (4.8%) died from enteritis or sepsis. CONCLUSIONS: In Japan, pediatric CIPO is a rare, serious, and intractable disease. The prognosis with respect to survival is good, but unsatisfactory because of the need for prolonged parenteral nutrition and associated potential for restricted quality of life.


Subject(s)
Intestinal Pseudo-Obstruction/epidemiology , Population Surveillance , Adolescent , Adult , Child , Child, Preschool , Chronic Disease , Female , Humans , Infant , Infant, Newborn , Intestinal Pseudo-Obstruction/diagnosis , Japan/epidemiology , Male , Prevalence , Prognosis , Retrospective Studies , Surveys and Questionnaires , Young Adult
18.
J Trace Elem Med Biol ; 28(4): 409-13, 2014 Oct.
Article in English | MEDLINE | ID: mdl-25294396

ABSTRACT

The authors analyzed serum selenium levels of 95 children and adolescents with intestinal dysfunction and/or neurological disabilities [age range: 7 months-20 years; mean±standard deviation (SD): 8.0±5.3 years] who received parenteral nutrition (PN) and/or enteral nutrition (EN) with either reduced or no selenium doses for more than 3 months. Twenty-eight patients (29%) showed serum selenium levels below 4.0µg/dL. Five patients whose serum selenium levels were below 2µg/dL presented various clinical manifestations, including hair browning (n=5), macrocythemia (n=4), nail whitening (n=3) and cardiac dysfunction (n=1). None of these 5 patients were nourished through ordinary diets. Three of these patients were nourished through selenium-free enteral nutritional products, 1 through selenium-deficient PN and 1 through PN and a formula with reduced selenium. After selenium supplement therapy for 1 year, all 5 patients exhibited improvement in their serum selenium levels and clinical features of selenium deficiency. It is important to be cautious about secondary selenium deficiency in children and adolescents nourished only through EN/PN without an adequate dose of selenium.


Subject(s)
Parenteral Nutrition , Selenium/deficiency , Adolescent , Adult , Child, Preschool , Female , Humans , Male , Selenium/administration & dosage , Young Adult
19.
Pediatr Int ; 56(4): e48-51, 2014 Aug.
Article in English | MEDLINE | ID: mdl-25252072

ABSTRACT

X-linked alpha thalassemia mental retardation (ATR-X) syndrome is an X-linked recessive disorder that often involves gastrointestinal symptoms. Aspiration pneumonia related to gastroesophageal reflux has been reported as the major cause of death, but gastrointestinal function has not been well investigated. The present report describes a child with ATR-X syndrome who suffered from periodical episodes of refractory vomiting. We investigated the function of upper alimentary tract and found that esophago-gastric dysmotility and severe gastric volvulus were the major causes of gastrointestinal symptoms. This child was surgically treated with anterior gastropexy and jejunal alimentation through gastrostomy, and the symptoms were relieved with good weight gain. This report may provide insight into the gastrointestinal function and nutritional management in children with ATR-X syndrome.


Subject(s)
Esophagus/physiopathology , Mental Retardation, X-Linked/physiopathology , Stomach/physiopathology , alpha-Thalassemia/physiopathology , Esophageal Motility Disorders/complications , Humans , Infant, Newborn , Male
20.
Pediatr Surg Int ; 30(9): 927-31, 2014 Sep.
Article in English | MEDLINE | ID: mdl-25074732

ABSTRACT

PURPOSE: To clarify the effects of rikkunshito on acid reflux, non-acid reflux, and esophageal clearance in patients with gastroesophageal reflux disease (GERD). METHODS: We enrolled seven patients with vomiting and/or stridor (median 6 years; 1 month-17 years), with a percent total time of esophageal pH <4.0 (reflux index) over 4.0%. Rikkunshito (TJ-43; Tsumura Co, Tokyo, Japan) was given in three divided doses before meals. We retrospectively investigated its efficacy using pH-multichannel intraluminal impedance before and 7 (6-10) days after starting treatment. Statistical analyses were conducted using Wilcoxon signed-rank test. RESULTS: In the pH analyses alone, the median number of acid reflux episodes >5 min (14 versus 10, p = 0.046) and median acid-clearance time (184 versus 134 s, p = 0.03) decreased significantly, although median decrease in reflux index did not reach significance (16.0 versus 17.9%, p = 0.06). In the combined impedance and pH analyses, the median number (36 versus 36, p = 0.03) and median duration (1.9 versus 1.1%, p = 0.046) of acid reflux decreased significantly; non-acid reflux and bolus clearance time did not change. CONCLUSION: Rikkunshito effectively reduced acid reflux, but not esophageal clearance, in patients with GERD.


Subject(s)
Drugs, Chinese Herbal/therapeutic use , Esophageal pH Monitoring , Gastroesophageal Reflux/drug therapy , Medicine, Chinese Traditional/methods , Adolescent , Child , Child, Preschool , Electric Impedance , Female , Humans , Hydrogen-Ion Concentration/drug effects , Infant , Male , Retrospective Studies , Treatment Outcome
SELECTION OF CITATIONS
SEARCH DETAIL
...