A vertebral artery aneurysm that elicited occipital pain, showed no abnormalities on imaging studies, but ruptured the next day: illustrative case.

BACKGROUND: The authors report the case of a patient with occipital headache whose imaging studies revealed no abnormalities but who died 1 day later due to vertebral artery (VA) aneurysm rupture. OBSERVATIONS: A male in his 40s with no relevant medical history had been taking over-the-counter medication for headache several times a month. One day before he visited our neurosurgery department, he experienced occipital headache, took the usual medicine, and applied a warm compress. Brain magnetic resonance imaging (MRI) and magnetic resonance angiography (MRA) studies returned no abnormal findings, and he went home. On the following day, his wife found his lifeless body in rigor mortis and requested a medicolegal autopsy. Preautopsy brain computed tomography showed diffuse subarachnoid hemorrhage (SAH). Histopathologically, there was no obvious VA dissection. The vascular wall at the rupture site lacked internal elastic lamina and media, it was covered only with thin fibrous connective tissue, and the adventitia was expanded. The cause of death was determined to be SAH due to rupture of a VA blister aneurysm. LESSONS: In our patient, brain MRI and MRA studies returned no abnormal findings. However, he died suddenly the next day. Autopsy identified SAH due to rupture of a blister-like VA aneurysm without dissection.

Magnetic Resonance Imaging Findings in Patients with Tarsal Tunnel Syndrome.

Tarsal tunnel syndrome (TTS) is a common entrapment syndrome whose diagnosis can be difficult. We compared preoperative magnetic resonance imaging (MRI) and operative findings in 23 consecutive TTS patients (28 sides) whose mean age was 74.5 years. The 1.5T MRI sequence was 3D T2* fat suppression. We compared the MRI findings with surgical records and intraoperative videos to evaluate them. MRI- and surgical findings revealed that a ganglion was involved on one side (3.6%), and the other 27 sides were diagnosed with idiopathic TTS. MRI visualized the nerve compression point on 23 sides (82.1%) but failed to reveal details required for surgical planning. During surgery of the other five sides (17.9%), three involved varices, and on one side each, there was connective tissue entrapment or nerve compression due to small vascular branch strangulation. MRI studies were useful for nerve compression due to a mass lesion or idiopathic factors. Although MRI revealed the compression site, it failed to identify the specific involvement of varices and small vessel branches and the presence of connective tissue entrapment.

Therapeutic Effect of Mirogabalin on Peripheral Neuropathic Pain due to Lumbar Spine Disease.

STUDY DESIGN: Retrospective study. PURPOSE: This study aims to evaluate the effectiveness of mirogabalin in treatment of peripheral neuropathic pain due to lumbar spine disease. OVERVIEW OF LITERATURE: Mirogabalin is a novel selective ligand for the α2δ subunit of voltage-gated Ca channels. METHODS: Between April and December 2019, we used mirogabalin to treat 60 consecutive patients (mean age, 67.6 years) with leg symptoms due to lumbar disease. The treatment outcome after 8 weeks of mirogabalin therapy was evaluated by comparing the preand post-administration Numerical Rating Scale (NRS) for leg symptoms and sleep disturbance, the NRS and Roland-Morris Disability Questionnaire for low back pain (LBP), and the quality of life (QOL) score (based on EuroQol five-dimension five-level scale). RESULTS: Mirogabalin treatment was stopped at less than eight weeks in eight patients. The remaining 52 patients for evaluation were divided as group 1 (17 patients who presented with leg symptoms that lasted for less than 3 months) and group 2 (35 patients with leg symptoms that lasted longer than 3 months). The leg symptoms and LBP in both groups significantly improved at 4 and 8 weeks of treatment, and sleep disturbance and QOL were improved at 8 weeks as well. Compared to group 2, the pretreatment leg symptoms and QOL were significantly worse in group 1, and their improvement after 8 weeks of mirogabalin treatment was significantly better (p<0.05). Of the 60 original patients, 17 suffered adverse effects, which were mild in 16 patients and required treatment cessation due to excessive weight gain in one patient. CONCLUSIONS: We have validated the effect of mirogabalin on neuropathic pain due to lumbar spine disease, which has effectively addressed the associated leg symptoms, LBP, and sleep disturbance.

Is the Vertebral Posterior Line a Safety Landmark for Cervical Posterior Screw Insertion? - Radiological Study of the Vertebral Artery in the Cervical Spine.

At posterior cervical fixation, iatrogenic injury of the vertebral artery (VA) must be avoided. As the VA is usually located in front of the posterior line of the vertebral body, intraoperative lateral fluoroscopy is used to identify the line. We investigated in how many of 105 patients (210 VAs) this line is a safe marker. We also inspected the original cervical magnetic resonance angiograms (MRA) of 105 consecutive patients who had been treated for other than cervical spine diseases to study some anatomical characteristics of the VA in the cervical spine. The distance from the posterior line of the vertebral body to the posterior VA surface was classified as safe, as requiring attention, and as unsafe. Among the 210 VAs, four hypoplastic vessels were excluded from this study; consequently, 206 VAs were available for assessment. The average distance exceeded 6 mm, it was shorter at the upper cervical level. Although in at least 200 VAs (97.1%) the distance between C4 and C7 was safe, in only 170 VAs (82.5%) was it safe at C3. We observed a total of 31 tortuous loops in 17 VAs; their presence had a significant negative effect on the usefulness of the safety line. Although the posterior line of the vertebral body may be useful for safe screw insertion at the C4-C7 level, it may be less useful at C3. In the presence of tortuous VA loops, close attention must be paid to the reliability of the safety line during cervical spine surgery.

[Magnetic Resonance Imaging Conditions for Imaging of the Tarsal Tunnel].

BACKGROUND: Tarsal tunnel syndrome(TTS)is an entrapment neuropathy of the posterior tibial nerve within the tarsal tunnel below the medial malleolus. An accurate diagnosis is difficult, and TTS is usually diagnosed from clinical symptoms due to the lack of accurate diagnostic tools. We aimed to standardize the diagnosis of TTS using MRI, and report the MRI conditions for clear visualization of the tarsal tunnel. METHODS: We investigated which sequences and MRI conditions would be appropriate for the imaging of the tarsal tunnel in a healthy volunteer. As in routine brain MRI, the imaging time was within 15 minutes. We also performed an MRI study of the tarsal tunnel in two patients with TTS. RESULTS: Axial images obtained by fat-suppression 3-dimensional T2*-weighted imaging(3D-T2*WI)are the most useful for visualization of the tarsal tunnel. The axial images obtained by T2-weighted imaging(T2WI)and T1-weighted imaging(T1WI)were also useful for visualization of the area around the flexor retinaculum. The appropriate slice thickness was determined to be 1.5 mm, based on the resolution and photographic time. The flip angle, necessary for tissue resolution, was set at 15° because it provided the clearest image and highest contrast between different tissues. The total photographic time was within 14 minutes, and it is acceptable for routine MRI studies of TTS. In the two cases of TTS included in this study, the tarsal tunnel was clearly visible. CONCLUSIONS: For diagnosis of TTS using MRI, axial images obtained by fat-suppression 3D-T2*WI, 2-dimensional(2D)-T2WI, and 2D-T1WI are recommended. A coronal image obtained by reconstruction of fat-suppression 3D-T2*WI might be useful for anatomical understanding. In future studies, we plan to evaluate patients with TTS using the above protocol.