SPINDILOMETER: a model describing sleep spindles on EEG signals for polysomnography.

This paper aims to present a model called SPINDILOMETER, which we propose to be integrated into polysomnography (PSG) devices for researchers focused on electrophysiological signals in PSG, physicians, and technicians practicing sleep in clinics, by examining the methods of the sleep electroencephalogram (EEG) signal analysis in recent years. For this purpose, an assist diagnostic model for PSG has been developed that measures the number and density of sleep spindles by analyzing EEG signals in PSG. EEG signals of 72 volunteers, 51 males and 21 females (age; 51.7 ± 3.42 years and body mass index; 37.6 ± 4.21) diagnosed with sleep-disordered breathing by PSG were analyzed by machine learning methods. The number and density of sleep spindles were compared between the classical method (EEG monitoring with the naked eye in PSG) ('method with naked eye') and the model (SPINDILOMETER). A strong positive correlation was found between 'method with naked eye' and SPINDILOMETER results (correlation coefficient: 0.987), and this correlation was statistically significant (p = 0.000). Confusion matrix (accuracy (94.61%), sensitivity (94.61%), specificity (96.60%)), and ROC analysis (AUC: 0.95) were performed to prove the adequacy of SPINDILOMETER (p = 0.000). In conclusion SPINDILOMETER can be included in PSG analysis performed in sleep laboratories. At the same time, this model provides diagnostic convenience to the physician in understanding the neurological events associated with sleep spindles and sheds light on research for thalamocortical regions in the fields of neurophysiology and electrophysiology.

Effect of teeth clenching on handgrip force in adult men: role of periodontal mechanoreceptors.

PURPOSE: Voluntary teeth clenching is shown to increase the strength of muscle reflexes contributing to the improvement of postural stability. However, the interaction between the handgrip strength and teeth clenching is not yet understood. In this study, we aimed to evaluate the change in handgrip force in response to voluntary teeth clenching, and its relation to the peripheral receptors that play a central role in the control of mastication. METHODS: Thirty-six healthy men were divided into two groups: aged 50-59 years, no dental prosthesis, and 53-62 years with total dental prosthesis. Each individual was given handgrip and teeth clenching instructions for five experiments: only handgrip, teeth clenching followed by handgrip without teeth clenching, teeth clenching followed by handgrip with teeth clenching, and the repetition of the last two instructions while wearing mouth guards. RESULTS: Our findings showed that maximum handgrip force decreased and the resistance to fatigue increased in complete edentulous individuals using appropriate prostheses. Also, the significantly lower maximum handgrip force and higher resistance to fatigue values of the participants with dental prosthesis using a mouth guard while teeth clenching, revealed the central roles of periodontal mechanoreceptors. CONCLUSION: Decreases in masticatory sensory information processes influence handgrip force values which is the most important indicator of motor function. The lack of periodontal mechanoreceptors associated with dental prosthesis usage may lead to a loss in muscle strength.

The relationship between snoring sounds and EEG signals on polysomnography.

PURPOSE: The aim of this study was to analyze the relationship of snoring sound signals obtained by polysomnography (PSG) in the sleep laboratory with cortical EEG (6 channel) signals to find answers to two important questions that have been covered to a limited extent in the literature: (1) Would the sounds generated by a snoring individual have an effect on the cerebral electrical waves occurring during sleep (specifically deep restorative sleep)? (2) Would the snoring sounds of an individual being examined by PSG have more of an effect on any one of the EEG electrodes? METHODS: PSG recordings were obtained from volunteers with primary snoring and those with obstructive sleep apnea syndrome (OSAS) on six different EEG channels (F4-M1, C4-M1, and O2-M1, F3-M2, C3-M2, and O1-M2). The relationship of each of these recordings and snoring sound signals was analyzed by using a computer-based electrophysiological signal analysis method. A three-tier approach was used in this relationship: "Feature extraction, Feature selection, and Classification". RESULTS: Data were obtained from a total of 40 volunteers (32 men, mean age (± SD) 47.5 ± 3.2 years), 20 with primary snoring and 20 with OSAS. The discrete wavelet transform (DWT) feature extraction method was the most successful method, and by utilizing this method for analyzing EEG channels, snoring sound signals were found to affect the C3-M2 channel the most (Duncan test, p < 0.05). Delta wave frequency levels during snoring were decreased compared to both before snoring (p = 0.160) and after snoring (p = 0.04) periods (paired sample test). DISCUSSION: When snoring sounds and EEG signals were analyzed for frequency, time, and wave conversion with feature extraction methods, the C3-M2 channel was to be found the most affected channel. The sleep physiologist who made the PSG analyses reported that, among the 6 EEG channels analyzed for periods where there was no apnea or hypopnea events but only snoring, C3-M2 was the channel showing changes in delta wave activity. CONCLUSION: Our study showed that the monotonous and repetitive snoring sounds of the snorer do not wake the individual, but do affect deep restorative sleep (N3). PSG signal analysis revealed that the most significant changes were in the C3-M2 channel (N3 delta wave amplitude increase and frequency decrease during snoring). Thus, clinicians may be able to monitor the characteristic changes occuring in large cortical delta waves in snoring individuals with innovative single-channel EEG devices without microphones.

SNORAP: A Device for the Correction of Impaired Sleep Health by Using Tactile Stimulation for Individuals with Mild and Moderate Sleep Disordered Breathing.

Sleep physiology and sleep hygiene play significant roles in maintaining the daily lives of individuals given that sleep is an important physiological need to protect the functions of the human brain. Sleep disordered breathing (SDB) is an important disease that disturbs this need. Snoring and Obstructive Sleep Apnea Syndrome (OSAS) are clinical conditions that affect all body organs and systems that intermittently, repeatedly, with at least 10 s or more breathing stops that decrease throughout the night and disturb sleep integrity. The aim of this study was to produce a new device for the treatment of patients especially with position and rapid eye movement (REM)-dependent mild and moderate OSAS. For this purpose, the main components of the device (the microphone (snore sensor), the heart rate sensor, and the vibration motor, which we named SNORAP) were applied to five volunteer patients (male, mean age: 33.2, body mass index mean: 29.3). After receiving the sound in real time with the microphone, the snoring sound was detected by using the Audio Fingerprint method with a success rate of 98.9%. According to the results obtained, the severity and the number of the snoring of the patients using SNORAP were found to be significantly lower than in the experimental conditions in the apnea hypopnea index (AHI), apnea index, hypopnea index, in supine position's AHI, and REM position's AHI before using SNORAP (Paired Sample Test, p < 0.05). REM sleep duration and nocturnal oxygen saturation were significantly higher when compared to the group not using the SNORAP (Paired Sample Test, p < 0.05).