ABSTRACT
The levels of urokinase (uPA) and tissue type (tPA) plasminogen activators and their type 1 inhibitor (PAI-1) were determined by immunoassay in tumor cytosols and samples of histologically unaltered adjacent mucosa in gastric cancer patients. Gastric tumor revealed enhanced uPA and PAI-1 matched by decreased tPA in intact mucosa. The expression of uPA and PAI-1 was particularly was high at the later stages of the disease. The concentrations of uPA in tumor tissue increased with age. No significant correlation was established between levels of plasminogen activation system components, on the one hand, and histopathological grading of tumor, on the other.
Subject(s)
Biomarkers, Tumor/analysis , Plasminogen Activator Inhibitor 1/analysis , Stomach Neoplasms/chemistry , Tissue Plasminogen Activator/analysis , Urokinase-Type Plasminogen Activator/analysis , Adolescent , Adult , Age Factors , Aged , Cytosol/chemistry , Female , Gastric Mucosa/chemistry , Humans , Immunoassay , Male , Middle Aged , Stomach Neoplasms/enzymologyABSTRACT
In the article is summarized the experience of treatment of 15 patients with dysplastic lumbar scoliosis of the II and III degree by the method of electrostimulation of dorsal muscles by means of walking corrector. Stimulation of the given type has been employed as rehabilitation therapy after carrying out of the closed chemonucleolysis for the purpose of muscle jacket restoration. Stimulation of trunk muscles in walking allowed to increase correction and stability of vertebral column distortion. Dynamic observations of patients demonstrated stability of achieved curative effect. Therapy of described type can be employed in complex of conservative treatment of scoliosis.
Subject(s)
Electric Stimulation Therapy/methods , Lumbar Vertebrae/abnormalities , Muscles/physiopathology , Scoliosis/therapy , Walking , Adolescent , Back , Child , Child, Preschool , Female , Humans , Male , Scoliosis/rehabilitationABSTRACT
Pronounced changes in the content of collagen, non-collagen proteins and the activity of a number of lysosomic enzymes have been established in the bone tissue of the vertebral bodies obtained on diskepiphysectomy in the patients with dysplastic scoliosis. Numerous correlation links between the metabolic parameters and the spinal deformation a year after diskepiphysectomy have been determined.
Subject(s)
Intervertebral Disc/surgery , Scoliosis/surgery , Thoracic Vertebrae/surgery , Acetylglucosaminidase/deficiency , Adolescent , Female , Galactosidases/deficiency , Glucuronidase/deficiency , Glycosaminoglycans/metabolism , Humans , Hydroxyproline/metabolism , Intervertebral Disc/metabolism , Male , Recurrence , Scoliosis/metabolism , Tensile Strength , Thoracic Vertebrae/abnormalities , Thoracic Vertebrae/metabolism , Tyrosine/metabolismABSTRACT
The authors summarize their experience in the treatment of 106 patients with dysplastic lumbar and thoracolumbar scoliosis. Already 24 hours after closed chemonucleolysis there was considerable correction of the curvature and an increase in the stability index. The method may be recommended for the treatment of lumbar and thoracolumbar scoliosis at stages II and III if the curvature angle does not exceed 50 degrees. In severe curvatures the efficiency of chemonucleolysis is low. Observation of the patients showed that the method causes little traumatism, is easily endured by the patients and allows for reliable discontinuation of the progress of deformation. The complications after closed chemonucleolysis may be avoided by employing the technique of discography, the application of the plaster-of-Paris jacket and by making use of adequate anaesthetic and dehydration therapy during the immediate post-manipulation period. The complications after chemonucleolysis did not deteriorate the results of the treatment.
