[Differential prevention of recurrence of thrombosis during pregnancy]. / Differentsirovannaia profilaktika retrombozov vo vremia gestatsionnogo protsessa.

Pregnancy in patients with a history of thrombotic complications puts them at a great risk of thrombosis and obstetric complications (hypoxia, intrauterine hypotrophy, bleedings). Functional strain of the hemostasis system occurs at the onset of pregnancy in women with a history of thrombotic complications without clinical symptoms of thrombosis. The incidence of disseminated intravascular coagulation with activation of both pro-coagulation and platelet-mediated hemostasis is 33% and that with activation of only platelet-mediated hemostasis is 64%. Differential use of antithrombotic drugs prevents thrombosis recurrence in 98% of patients.

[Heparin therapy of pregnant women with placental insufficiency]. / Geparinoterapiia u beremennykh s platsentarnoi nedostatochnos'tiu.

In the presence of low-dosage administrations of heparin the system of hemostasis was studied in 50 pregnant females with placental failure and the chronic DIC syndrome. The efficacy of the treatment conducted was assessed with regard to the revealed levels of coagulation natural inhibitors, the products of fibrinogen-fibrin degradation, the degree of thrombocytic functional recovery and stabilization of the chronometric values of coagulation. The latter parameters considered together with the levels of heparinemia served as the criteria for the safety of the drug dosages employed.