Enhancing medication use safety: benefits of learning from your peers.

BACKGROUND: Maryland hospitals have been improving the safety of medication use practices since 2000. A retrospective analysis of 35 hospitals was conducted for 2005-2007 to determine the changes in medication use practices, communication methods within hospitals, patient education and changes in medical record management. METHODS: Thirty-five Maryland hospitals completed the Institute for Safe Medication Practices Medication Safety Self-Assessment for Hospitals, a voluntary initiative to improve the safety of medication use. A weighting structure is applied to calculate key element scores, core characteristic scores and overall self-assessment scores that were used in ANOVA and regression analyses. FINDINGS: The state-wide aggregate score significantly increased from 74.2% in 2005 to 81.2% in 2007 (p<0.05). The 35 hospitals scored highest in the following key areas in 2007: drug standardisation, storage and distribution (90.2%); drug labelling, packaging and nomenclature (88.1%); and environmental factors (84.3%). Results indicated that hospitals scored lowest in the key element area related to accessibility of patient information (72.5%) and in the core characteristics pertaining to redundancies and independent double checks (64.2%) in 2007. A substantial number of hospitals had positive and significant (p<0.05) changes in certain key elements and/or core characteristics. Few hospitals showed significant (p<0.05) decreases in their scores. CONCLUSION: MEDSAFE has directly assisted Maryland hospitals in improving medication use safety. The strategies and tools of MEDSAFE have been used in Maryland since 2000 and Singapore and Austria since 2006.

A performance assessment framework for hospitals: the WHO regional office for Europe PATH project.

OBJECTIVE: The World Health Organization (WHO) Regional Office for Europe launched in 2003 a project aiming to develop and disseminate a flexible and comprehensive tool for the assessment of hospital performance and referred to as the performance assessment tool for quality improvement in hospitals (PATH). This project aims at supporting hospitals in assessing their performance, questioning their own results, and translating them into actions for improvement, by providing hospitals with tools for performance assessment and by enabling collegial support and networking among participating hospitals. METHODS: PATH was developed through a series of four workshops gathering experts representing most valuable experiences on hospital performance assessment worldwide. An extensive review of the literature on hospital performance projects was carried out, more than 100 performance indicators were scrutinized, and a survey was carried out in 20 European countries. RESULTS: Six dimensions were identified for assessing hospital performance: clinical effectiveness, safety, patient centredness, production efficiency, staff orientation and responsive governance. The following outcomes were achieved: (i) definition of the concepts and identification of key dimensions of hospital performance; (ii) design of the architecture of PATH to enhance evidence-based management and quality improvement through performance assessment; (iii) selection of a core and a tailored set of performance indicators with detailed operational definitions; (iv) identification of trade-offs between indicators; (v) elaboration of descriptive sheets for each indicator to support hospitals in interpreting their results; (vi) design of a balanced dashboard; and (vii) strategies for implementation of the PATH framework. CONCLUSION: PATH is currently being pilot implemented in eight countries to refine its framework before further expansion.

Errors: can indicators measure the magnitude?

Errors in medicine, especially medication errors, have long been recognized as a dimension of quality of care and organizational performance. Recently, however, the magnitude of the issue, or its potential impact on cost, quality of care and patient safety have catapulted this issue to the forefront of national debate on the appropriateness of patient care management. There are still fundamental issues associated with the measurement of errors. Should errors that do not cause patient harm receive much attention? Could there be organizational or system issues that predispose to errors? Are there acceptable measurement models that allow comparative analysis and trending of institutional error rate profiles? This paper presents a systematic review of the measurement aspects for errors in medicine, emphasizing the medication errors' dimension. An indicator-based, epidemiological model of measurement is proposed which will allow a systematic inquiry into the issues of both preventable and non-preventable errors and their potential for patient harm.

Performance: a multi-disciplinary and conceptual model.

We contend that the scientific study of performance requires a model or paradigm. We propose a performance model with an underlying mathematical basis that is well defined, has explicit assumptions and has the potential to be both heuristic and scientifically testable. The model is based on an integration of concepts from health sciences and psychology that have been adapted to performance measurement in health care. The proposed performance model consists of a combination of four primary elements: quality of care, cost of care, access to care and satisfaction. Satisfaction is defined as a function of perceived and expected outcomes of care and perceived and expected input. This performance model can serve as both a tool for understanding and as a vehicle for comparing performance within and between health care organizations. We believe that this model can be used to develop a performance profile report and the future report card.

A new learning environment: combining clinical research with quality improvement.

The emphasis provided by quality improvement strategies on performance measurement and evaluation often results in our understanding of processes of care and, perhaps, better outcomes. There are different references for process evaluation: external peers, regional profiles of performance or a trending of one's own performance patterns. This paper proposes a methodology that enables learning from the daily practice of medicine by comparing alternative care processes and outcomes. Since it is estimated that 15-20% of medical practices are based on rigorous scientific data establishing their effectiveness, we have much to learn. We propose to learn from our daily practice by combining clinical research methods with quality improvement tools. The products comprise modified clinical trial and case-control studies. In a modified clinical trial, we would use a practice guideline as a control group and modify the guideline to create an experimental group. This method would maintain the internal validity of efficacy research while maintaining the external validity of effectiveness research. In the case-control method, it is possible to quantitate risk for a given outcome and focus improvement effort on factors associated with that outcome. We believe physicians will accept this learning approach because it is a more valid learning method than traditional quality improvement and, unlike randomized clinical trials, learning will occur in the daily practice of medicine.

Impact of risk adjusted clinical outcomes methodology--quality measures on hospital mortality data: a statistical and case study approach.

The effectiveness of risk adjustment in improving mortality as a performance measure for hospitals remains uncertain. New techniques of risk adjustment should be empirically tested, and health care professionals, using the data derived from such measures, should be queried before final acceptance of these technologies of measurement is warranted. The Risk Adjusted Clinical Outcomes Methodology-Quality Measures (RACOM-QM), a relatively new risk-adjustment methodology developed by the QuadraMed Corporation, was used by Maryland hospitals for risk adjustment for the first time in 1997. A research study was undertaken by the Maryland Hospital Association to determine the impact of RACOM-QM on mortality rates, its empirical validity, and its acceptance in the field. The relationship between RACOM-QM mean risk scores and mortality rates was examined using inpatient hospital mortality data for Maryland in 1996. Using these same data, the empirical relationship between risk-adjusted and unadjusted mortality by diagnosis-related group (DRG) was also investigated. Case studies were undertaken to glean information about the use and acceptability of this new methodology in 2 hospital settings in Maryland. There was a strong relationship between mean mortality risk scores and mortality rates. The analysis of the empirical relationship between risk-adjusted and unadjusted mortality by DRG yielded support for the impact of RACOM-QM in adjusting inpatient mortality rates. The case studies supported the utility of this method of risk adjustment in increasing the interpretation of mortality data and in helping to identify areas in which to investigate quality in more depth in 2 hospital settings. This study provides overall support for the usefulness of risk adjustment and, specifically, the RACOM-QM, in increasing the interpretation of inpatient mortality rates in Maryland's acute care hospitals. This study also suggests that use of the RACOM-QM improved comparative analysis of inpatient mortality rates among Maryland hospitals. Finally, the results of the case study analysis suggest that improved internal review of mortality rates and increased clinician acceptance of these rates as indicators of performance were enhanced by the use of a risk adjustment methodology.

Cesarean section rates: effects of participation in a performance measurement project.

BACKGROUND: A decade-old indicator-based research initiative, Maryland's Quality Indicator (QI) Project, analyzed data for cesarean section rates among its approximately 1,100 voluntarily participating hospitals. It was posited that continuous participation in this performance measurement initiative would be associated with decreased primary and repeat C-section rates. METHODS: A retrospective study compared a group of 110 hospitals that reported on the C-section indicator continuously between 1991 and 1996 with a group of hospitals that did not continuously report data on the C-section rate. RESULTS: Among the 110 continuously participating hospitals in the QI Project, the total C-section rate declined from 22.5% in 1991 to 19.4% in 1996 (p < .01). For this same group, the primary C-section rate declined from 15.8% to 13.9% (p < .01), and the repeat C-section rate declined from 75.0% to 61.2% between 1991 and 1996 (p < .01). The comparison group of 957 hospitals that did not continuously participate in C-section reporting between 1991 and 1996 did not experience a statistically significant difference in total C-section rates during this time (from 21.2% in 1991 to 20.7% in 1996). In attempting to investigate alternative explanations for these results, a subsequent analysis of eight hospital variables potentially related to cesarean delivery rates found no significant differences between the two groups. CONCLUSIONS: This study provides support for the positive association between continuous participation in a performance measurement project and performance improvement.

Directly observed therapy for treatment completion of pulmonary tuberculosis: Consensus Statement of the Public Health Tuberculosis Guidelines Panel.

OBJECTIVE: To evaluate evidence on the relative effectiveness of directly observed therapy in achieving treatment completion for pulmonary tuberculosis. PARTICIPANTS: A panel of 11 practitioners representing the public health, behavioral, and clinical management of tuberculosis was convened by the Council on Linkages Between Academia and Public Health Practice in 1995 to develop public health guidelines for tuberculosis treatment completion. EVIDENCE: English-language articles identified through MEDLINE (1966 to August 1, 1996) with original data on directly observed therapy, supervised therapy, compliance, treatment completion, case management, and treatment adherence for tuberculosis. CONSENSUS PROCESS: Each eligible article underwent structured review by at least 2 panel members for study design, sample size, evaluation methods, and treatment completion as the primary outcome. The full panel was convened twice, with intercurrent small group meetings, conference calls, and summary workshop to review findings. Recommendations made through this process were drafted by the panel chair and circulated twice for additional panel comments. CONCLUSIONS: Treatment completion rates for pulmonary tuberculosis are most likely to exceed 90%, as recommended by the Centers for Disease Control and Prevention, when treatment is based on a patient-centered approach using directly observed therapy with multiple enablers and enhancers. Other less intensive interventions, including nonsupervised strategies and modified approaches to directly observed therapy, are unlikely to achieve this recommended treatment completion goal. Directly observed therapy also appears to be cost-effective compared with self-administered therapy, although data on cost-effectiveness are limited.

A Hawthorne strategy: implications for performance measurement and improvement.

The Hawthorne experiments are a backdrop for diverse studies assessing the impact of treatment and experimentation on human and organizational performance. The Hawthorne effect is used to describe the positive impact on behavior that sometimes occurs in a study or experiment as a result of the interest shown by the experimenter in humans who are being treated, studied, or observed. We propose that the Hawthorne effect can be viewed as an active construct to develop a coherent strategy for performance improvement. We propose a "Hawthorne strategy" that transcends the Hawthorne effect in that it offers an approach to improving performance indefinitely. This strategy uses external observations of performance to increase internal commitment to performance improvement. The focus of individual responsibility increases as does the perceived connection between individual efforts and external performance improvement. The sense of accountability is maintained by institutional recognition and periodic reinforcement of individual behaviors that contribute to performance improvement. A successful Hawthorne strategy encourages providers of care to be evaluators of their performance as individuals, as members of groups, and as members of institutions.

[Familial adenomatous polyposis and thyroid cancer]. / Polypose adénomateuse familiale et cancer de la thyroïde.

Familial adenomatous polyposis may exhibit extracolonic tumors which include thyroid carcinoma. It has been recently suggested that thyroid carcinomas associated with familial adenomatous polyposis show distinct histologic features different from sporadic follicular or papillary thyroid carcinomas. We report a case of thyroid carcinoma in a young girl affected by familial adenomatous polyposis, whose thyroid tumor exhibited some of these features. This finding confirms the peculiar histologic phenotype of the thyroid carcinomas associated with familial adenomatous polyposis. Alterations of the APC gene responsible for familial adenomatous polyposis may play a role in the development of these thyroid cancers.

Do performance indicators make a difference?

BACKGROUND: The Maryland Hospital Association, Inc (MHA) Quality Indicator (QI) Project, a program of indicator development and application, includes more than 1,100 participating hospitals. Access to data is limited to participants to promote improvement through comparison across hospitals. Participating hospitals have identified and acted on opportunities for improvement in information systems, communication across departments and functions, processes of care, identification of appropriateness of practice, and improvement ¿beyond the hospital door¿. CASE STUDY 1: Two teams were formed to address waiting time in the emergency department and failure of patients to find treatment. Improvements, including rapid notification of available inpatient beds, additional staffing during high-census periods, and streamlined processes for lab work and imaging turnaround times, were followed by better indicator performance. CASE STUDY 2: A hospital discovered three causes for a high rate of unscheduled admissions following ambulatory surgery. Interventions included extending the hours of the Same Day Surgery Unit (to solve a urination problem) and changing the anesthesia used (to reduce nausea and vomiting). CASE STUDY 4: To successfully bring its cesarean section (C-section) rate down closer to the statewide rate, one hospital had physicians encourage patients with previous C-sections to undergo a trial of labor, promoted the use of epidural anesthesia, and took advantage of new packaging to facilitate the use of prostaglandin gel to induce cervical dilation. CONCLUSIONS: The QI Project continues to deal with issues concerning quality of data versus quality of care, the correlation between indicator rates and care processes, and the usefulness of severity adjustment.

Pancreaticoduodenectomy in childhood for rare pancreatic ductal anomalies--case reports.

In the past 9 years, 3 children suffering rare pancreatic disorders have undergone cephalic pancreaticoduodenectomy (Whipple procedure) required after the failure of initial conservative treatments. Ductal anomalies such as pancreas divisum or predominant Santorini duct can be managed conservatively (especially by papillotomy of the minor papilla), unless the extent of the fibrotic lesions of the pancreas jeopardizes the final evolution of the pancreatic disease. Intrapancreatic gastric duplications remain extremely rare. Even to-day, diagnosis was made only on pathologic specimens after radical surgery. Better knowledge of this rare pathology, with emphasis on its radiological features, may help better assessment. Hemoductal pancreatitis is evocative of the coexistence of gastric duplication and pancreatic aberrant duct. However, when fibrotic and necrotic changes in the duodenopancreatic region are considerable, assessment of this anomaly becomes difficult. Radical though it is, pancreaticoduodenectomy may be necessary to treat cephalic pancreatic lesions in childhood after the failure of reasonable attempts of conservative treatment.