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Farmakol Toksikol ; 51(1): 12-4, 1988.
Article in Russian | MEDLINE | ID: mdl-2896131

ABSTRACT

Four new derivatives of glutamic and gamma-aminobutyric acids influencing the central nervous system were produced. By the character of their action they refer to the substances of the sedating tranquilizing type without the myorelaxant component. The drug activity degree depends on its ability to penetrate through cell membranes that is in turn determined by the structure of the compound.


Subject(s)
Glutamates/pharmacology , Nicotinic Acids/pharmacology , Psychotropic Drugs/pharmacology , gamma-Aminobutyric Acid/analogs & derivatives , Animals , Cell Membrane Permeability/drug effects , Dose-Response Relationship, Drug , Glutamic Acid , Mice , Motor Activity/drug effects , Structure-Activity Relationship , gamma-Aminobutyric Acid/pharmacology
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