Erratum: Publisher's Note: "Magneto-responsive hyaluronan hydrogel for hyperthermia and bioprinting: Magnetic, rheological properties and biocompatibility" [APL Bioeng. 7, 036113 (2023)].

[This corrects the article DOI: 10.1063/5.0147181.].

Magneto-responsive hyaluronan hydrogel for hyperthermia and bioprinting: Magnetic, rheological properties and biocompatibility.

Magneto-responsive soft hydrogels are used for a number of biomedical applications, e.g., magnetic hyperthermia, drug delivery, tissue engineering, and neuromodulation. In this work, this type of hydrogel has been fabricated from hyaluronan (HA) filled with a binary system of Al2O3 nanoparticles and multicore magnetic particles (MCPs), which were obtained by clustering of superparamagnetic iron oxide FeOx NPs. It was established that the presence of diamagnetic Al2O3 has several positive effects: it enhances the hydrogel storage modulus and long-term stability in the cell cultivation medium; prevents the magnetic interaction among the MCPs. The HA hydrogel provides rapid heating of 0.3 °C per min under exposure to low amplitude radio frequency alternating magnetic field. Furthermore, the magneto-responsive hydrogel was successfully used to encapsulate cells and extrusion-based 3D printing with 87±6% cell viability, thus providing a bio-ink. The combination of high heating efficiency, softness, cytocompatibility, and 3D printability of magnetic HA hydrogel leads to a material suitable for biomedical applications.

The formation mechanism of iron oxide nanoparticles within the microwave-assisted solvothermal synthesis and its correlation with the structural and magnetic properties.

Magnetic nanoparticles based on Fe3O4 were prepared by a facile and rapid one-pot solvothermal synthesis using FeCl3·6H2O as a source of iron ions, ethylene glycol as a solvent and NH4Ac, (NH4)2CO3, NH4HCO3 or aqueous NH3 as precipitating and nucleating agents. In contrast to previous reports we reduce the synthesis time to 30 minutes using a pressurized microwave reactor without the requirement of further post-treatments such as calcination. Dramatically reduced synthesis time prevents particle growth via Ostwald ripening thus the obtained particles have dimensions in the range of 20 to 130 nm, they are uniform in shape and exhibit magnetic properties with saturation magnetization ranging from 8 to 76 emu g(-1). The suggested method allows simple particle size and crystallinity tuning resulting in improved magnetic properties by changing the synthesis parameters, i.e. temperature and nucleating agents. Moreover, efficiency of conversion of raw material into the product is almost 100%.

[Normoxic therapeutic compression in stroke treatment]. / Normoksicheskaia kompressiia v lechenii insul'ta.

Objective. To analyze the effect and mechanisms of therapeutic compression in stroke. Material and methods. Clinical efficacy of normoxic therapeutic compression (NTC) was studied for two hyperbaric therapeutic regimes in patients with ischemic stroke of moderate severity. Results and conclusion. The therapeutic effect of the method was caused by the effect of excessive pressure on the energy metabolism, but not by the hyper oxygenation, with the elevation to normal pC02 and CO2 content in the exhaled air. The effect is stable only in the range 1.05-1.1 ATA and increased from session to session. In this range, there were the activation of energy metabolism and the recovery of cerebral microcirculation with the normalization of the acid-base state (ABS) and lipid peroxidation (LPO). The more excessive pressure in the pressure chamber (1.15-1.2 ATA ) resulted in less treatment effect, decreased pC02, increased blood plasma viscosity, worse AAE parameters and LPO activation. The degree of blood plasma oxygenation proved to be the main feature of hyperbaric therapeutic regimes studied.

[Coronarography in coronary heart disease in elderly patients of behavioral type A].

177 patients aged 32 to 74 years with CHD were examined. The data on angiographic situation and connection between the condition of coronary arteries and behavioral singularity of old-aged CHD patients of different behavioral types are revealed. The results of angiographic examination of heart vessels in old-aged CHD patients of behavioral type A are shown.

[Immunological markers of severity and outcome of traumatic brain injury].

A microscopic immunological study of cerebral spinal fluid (CSF) of 100 patients with traumatic brain injury (TBI) of different severity was carried out in the 1st, 10th and 21st days after trauma. The content of antibodies to basic myelin protein (BMP) and phospholipids (PL) significantly differed from that in the control group (patients with soft tissue head injuries without TBI) and was significantly higher in patients with severe TBI. The level of antibodies to BMP in the CSF was strongly correlated with scores on the Glasgow Coma Scale in the 1st day after TBI and the degree of recovery of neurological status in the 21st day. The level of antibodies to PL was strongly correlated with the severity of cytosis, content of CSF erythrocytes and proteins. The correlation between antibodies to BMP and antibodies to PL was weak. The different diagnostic value of antibodies to BMP and to PL in the most acute period of TBI was found. In conclusion, content of antibodies to BMP may be used as a marker of TBI severity and outcome while the significant elevation of antibodies to PL indicates the severity of vascular complications of trauma.

[The normoxic therapeutic compression effect on microcirculation in acute stroke].

The study evaluates efficacy of two hyperbaric therapeutic regimes--1,-51,1 atm and 1,2 atm in patients with an acute ischemic stroke. Acid-base equilibrium dynamics of capillary and venous blood, whole blood and plasma, platelet aggregation and lipid peroxidation were investigated. An analysis of the data revealed that, comparing to the conventional method, barotherapy in stroke is accompanied by a marked therapeutic effect. Barotherapy or normoxic therapeutic compression is principally different from other methods of oxygen therapy, because it is not resultant in blood plasma hyperoxygenation and in lipid peroxidation augmenting. Activation of tissue respiration in barotherapy accompanied by normalization of lipid peroxidation process and CO2 resources restoration leads to renewal of MKT microcirculation and autoregulation, thus providing a stable therapeutic effect of the method in brain ischemia.

Transition to linear domain walls in nanoconstrictions.

Domain walls in nanoconstrictions are investigated with a focus on thermal properties. In general, the magnetization component perpendicular to the easy axis which in a domain wall usually occurs has a value different from the easy-axis bulk magnetization value with a separate phase transition at a critical temperature below the Curie temperature. Since this effect is the more pronounced the smaller the domain wall width is, we investigate it especially in domain walls with a confined geometry, using analytical arguments, mean-field theory, and Monte Carlo simulations. Our findings may contribute to the understanding of magnetoresistive effects in domain walls with sizes of only a few atomic layers, as, e.g., in nanocontacts or nanoconstrictions.

[Barotherapy in cerebrovascular diseases]. / Baroterapiia pri sosudistykh zabolevaniiakh mozga.

It has been shown that the main problem of treating patients with cerebral ischemia using minimal excessive pressures is the choice of the optimum therapeutic dose. We propose a new method of treatment for cerebral vascular disorders with an application for minimum high pressure doses (< 1.1 ata with oxygen a air mixture). The aim of the present report is to summarize clinical results of this method and to estimate the mechanisms of its action. The main feature of the method described (barotherapy) is to bring external and cell respiration and recovery of oxygen autoregulation of cell respiration to normal values in patients with increased CO2 inner production. The administration of antioxidants transporting electrons on mitochondrial respiratory chain significantly improves the clinical outcome after barotherapy and leads to stabilization of lipid peroxidation.

[Magnetic soft siloxane material for arterial embolization and hyperthermia of malignant tumors]. / Magnitomiagkii siloksanovyi material dlia émbolizatsii arterial'nykh sosudov i gipertermii zlokachestvennykh opukholei,

A newly developed polysiloxan material for arterial embolization of parenchymatous organs is described. This new agent can be used for distal-proximal embolization with following local hyperthermia. The preliminary results of clinical use are presented.

[An evaluation of the immunotropic and hemopoietic effects of hyperbaric oxygenation as an experimental pathological model]. / Otsenka immunotropnogo i gemopoéticheskogo éffektov giperbaricheskoi oksigenatsii v kachestve éksperimental'noi patologicheskoi modeli.

Apoptosis, programmed cell death, being a physiological process is manifested by degenerative changes of the cell structures. Augmentation of apoptosis or distributed receptor-signal interaction of the cells may be caused by the toxic products of radiolysis and cancerogenesis. Hyperbaric oxygenation (HBO) was used as a model resembling apoptosis. The parameter of the humoral immune response to different HBO regimens and correction of immunodepression by a carotene-tocopherol complex (CTC) were compared. The next stage in the study of the CTC antioxidant effect in gamma-radiation was determination of the extent of endogenous colony formation under the influence of different HBO regimens. A moderate immunodepressive effect of HBO was noted. Combination of CTC and HBO in small regimens induced a moderate immunostimulating and hemopoietic response. The suggested pathological model may be used in study of antioxidants. CTC showed hemopoietic and immunocorrective action.

[Cytotoxic properties of the complex of the antineoplastic antibiotic bleomycetin and Bacillus intermedius ribonuclease]. / Tsitotoksicheskie svoistva kompleksa protivoopukholevogo antibiotika bleomitsetina i ribonukleazy Bacillus intermedius.

It was shown possible to change the cytotoxic properties of the antitumor antibiotic bleomycetin by its binding to Bacillus intermedius RNAse. The complexing lowered the antibiotic effect on DNA in the cells of the human amnion. At the same time the experiments with human red blood cells indicated that RNAse of B. intermedius in complex with bleomycetin-Fe(II) increased the antibiotic capacity for the cell membrane break down.

[The effect of different hyperbaric oxygenation regimens on the aggregate status of the blood and on the free-radical oxidation processes in patients with the initial manifestations of cerebral blood supply failure]. / Vliianie razlichnykh rezhimov giperbaricheskoi oksigenatsii na agregatnoe sostoianie krovi i protsessy svobodnoradikal'nogo okisleniia u bol'nykh s nachal'nymi proiavleniiami nedostatochnosti krovosnabzheniia mozga.

Blood rheology, hemocoagulation, free-radical oxidation, acid-alkaline condition of the capillary and venous blood were investigated in 62 ICIB patients before and after treatment which consisted of 8 hyperbaric oxygenation (HBO) sessions or 3 HBO sessions (1.5 atm and 1,2 atm, respectively), the rest patients were not exposed to HBO. The best therapeutic results were achieved with a short-term HBO at a small excessive pressure. The longer HBO regimen provided no positive tendencies in clinical parameters. On the contrary, it provoked blood rheology deterioration, activation of free-radical oxidation stemming from diminished adaptation to hyperoxia in ICIB.

[Effects of different regimens of hyperbaric oxygenation on transcriptional activity and morphology of frontal cortex neurons in occlusion of the common carotid artery in rats]. / Vliianie razlichnykh rezhimov GBO na transkriptsionnuiu aktivnost' i morfologiiu neironov lobnoi kory pri okkliuzii obshchei sonnoi arterii u krys.

The effect of different regimens of hyperbaric oxygenation (HBO) on cortical pyramids morphology and transcription were studied under occlusion of common arteria carotis. The effect of early (3 hours after occlusion) and late (14 hours after occlusion) use of 1.2 and 2.0 ata of HBO was estimated. The rats were killed 15 minutes or 24 hours after HBO session. The effect of early use of HBO was normalizing, stabilizing and independent on the dose. Protecting effect of the late HBO on morphology and transcription activity of nuclear chromatin of pyramids was higher in the 1.2 ata regimen. In case of late HBO both pressures produced depressing effect on the nucleoplasmic chromatin, transcription.

[Effects of different doses of hyperbaric oxygenation on morphology and transcription of cortical neurons of rats with experimental cerebral ischemia]. / Issledovanie vliianiia razlichnykh rezhimov GBO na morfologiiu i transkriptsiiu neironov kory krys s éksperimental'nym insul'tom.

Its effect of hyperbaric oxygenation (the doses 1.2 and 2 ata) on cortical pyramids of the rats with one-or both-side ligation of common arteria carotis 2.5 or 24 hours after operation was studied. The neuron survival and transcription activity were estimated. In all experimental situations except the most serious, e.g. 24 hours after the both-side artery ligation, the dose 2 ata was more effective. On the contrary, in most serious cases the dose 1.2 ata or applying in the baro-camera the air instead of oxygen provided the better result.

[Use of hyperbaric oxygenation in the treatment of acute cerebrovascular disorders in ischemic heart disease]. / Primenenie giperbaricheskoi oksigenatsii v lechenii ostrykh tserebrovaskuliarnykh rasstroistv pri ishemicheskoi bolezni serdtsa.

Altogether 22 patients with concomitant cardio-cerebral acute pathology underwent all-round examinations during and after sessions of hyperbaric oxygenation (HBO). The highest clinical effect was produced by minor, substituting doses of HBO. The revealed phasic nature of the action of HBO in the treatment of patients with acute large-focal myocardial infarction and acute cerebrovascular disorders was found to be due to changes in the function of diencephalic and brain stem formations, determining the decrease of adaptation potentialities in this patients' group. HBO was found to be clinically effective in the treatment of such patients. In order to raise the treatment efficacy, it is necessary that an individual approach be exercised in the choice of therapeutic HBO sessions.

[Clinico-metabolic status of fetuses and newborn infants with fetal macrosomia]. / Kliniko-metabolicheskii status ploda i novorozhdennogo pri rozhdenii s krupnoi massoi tela.

A study was made of the development of large fetuses during pregnancy with regard to the clinical picture, ultrasound screening of the placenta and fetuses, biochemical and immunological monitoring of blood of pregnant women, fetuses and neonates. 172 pregnant women were placed under observation. Of these, large fetuses (the main group) were born in 70 cases, whereas in 102 cases, the fetuses were of medium body weight (the control group). The comparison of the data obtained allows a conclusion that macrosomia gives rise to the acceleration of maturation of the fetal organs and systems, to the intensification of metabolism within the system mother--placenta--fetus.

[Hyperbaric oxygenation in the treatment of compression mononeuropathies]. / Giperbaricheskaia oksigenatsiia v lechenii kompressionnykh mononeiropatii.

105 patients with compression mononeuropathies were divided into 2 groups by duration of HBO performed under an original method. The effect of HBO treatment was assessed by changes in neurological symptoms and positive trend on ENMG. The most appreciable response was obtained in acute disease treated by 4-session short course. Longer courses of VIII-X sessions were less efficient.