[Use of the principle of reverse problems for detecting processes, occurring in cells suspended in culture. I. Distribution in the exponential growth phase of the age component of the cell population by its dynamic characteristics]. / Primenenie printsipa obratnykh zadach dliia vyiavleniia protsessov, proiskhodiashchikh v kletkakh pri ikh suspenzionnom kul'tivirovanii. I. Opredelenie v éksponentsial'noi faze rosta vozrastnogo sostava kletochnoi populiatsii po ee dinamicheskim kharakteristikam.

A mathematical model of age distribution in the suspension culture was verified. This model used the principle of reverse problems and allowed determination of age distribution from the cell numbers dynamics in the population. The verification was based on the complex non-destructive measurement of the microorganism parameters, which allowed simultaneous determination of the cell population dynamics and the distribution of cells according to their projection areas. The experiments were carried out on E. coli culture.

[Use of the principle of reverse problems for detecting processes, occurring in cells suspended in culture. II. Distribution of glutathione, SH groups, and optical density in the E. coli cell cycle]. / Primenenie printsipa obratnykh zadach dliia vyiavleniia protsessov, proiskhodiashchikh v kletkakh pri ikh suspenzionnom kul'tirovanii. II. Opredelenie glutationa, SH-grupp i opticheskoi plotnosti v kletochnom tsikle E. coli.

A method was proposed for calculating the content of intracellular components during the cell cycle of an individual cell. The principle of reverse problems was used in the mathematical model proposed. The model allowed us to calculate changes of intracellular parameters of an individual cell from corresponding parameters measured in the whole culture. Optical density, total SH-group and glutathione content in synchronous culture of E. coli were the parameters studied. The proposed method may be applied for both synchronous and asynchronous cell cultures.

[Diabetogenic properties of Coxsackie A13 and Coxsackie B4 viruses in experimental infection in mice]. / Diabetogennye svoistva virusov Koksaki A13 i Koksaki B4 pri éksperimental'noi infektsii u myshei.

Studies of diabetogenic properties of Coxsackie A13 and B4 viruses in mice sensitive to diabetes (males, DBA line) and resistant (males and females F1(CBA X C57BL/6), females DBA/2 using in the latter case the subdiabetogenic doses of alloxan revealed in the infected animals biochemical changes manifested by reduction of glucose tolerance and disorders in the synthesis of immunoreactive insulin. Most marked changes were observed in males of DBA/2 line infected with Coxsackie B4 virus and in males F1 (CBA X C57BL/6) and females DBA/2 infected with Coxsackie A14 virus. With Coxsackie A13 virus such data have been obtained for the first time.

[Experimental diabetes in mice infected with Coxsackie viruses]. / Eksperimental'nyi diabet u myshei, infitsirovannykh virusami Koksaki.

The influence of Coxsackie B4 and AI3 viruses on the pancreas of mice (resistant and susceptible to diabetes) was studied. Glucose intolerance and changes in the synthesis of immunoreactive insulin were detected in all the treated groups of animals. Biochemical changes were more prominent in male DBA/2 mice, infected with Coxsackie B4 virus, in FI (CBA X C57Bl/6) hybrids and in female DBA/2 mice infected with Coxsackie AI3 virus and alloxan.