[C-reactive protein and defect in lipid transport blood system in patients with rheumatoid arthritis]. / S-reaktivnyi belok i narusheniia lipid-transportnoi sistemy krovi u bol'nykh revmatoidnym artritom.

In 88 patients with rheumatoid arthritis lipid-protein spectrum of the blood serum were determined biochemically and by means of nefelometric technique, C-reactive protein (CRP) was measured with enzyme immunoassay. An increase in CRP concentration was associated with lowering of apoA1 and HDL FL, triglycerides. Thus, elevation of CRP in RA reflects not only activity of inflammation but also defects in serum lipid-transport system by the atherogenic type.

[The blood rheological properties in patients with amputation stumps and concomitant ischemic heart disease]. / Reologicheskie svoistva krovi u bol'nykh s kul'tiami konechnostei i soputstvuiushchei ishemicheskoi bolezn'iu serdtsa.

Blood rheology was compared in two groups of patients with ischemic heart disease (IHD). In group 1 patients low limbs were amputated. It is in them that rheological properties of blood were changed to the most extent. This is attributed to the effect of plasmic factors in the form of hypertriglyceridemia and hyperfibrinogenemia, sharp reduction of the total cross sectional vascular area (especially in high amputation) leading to blood cell damage associated with intensive platelet aggregation and red cell microhemolysis. Reduced muscular mass and resultant reduced capillary bed and deficiency of endothelial surface may stimulate accumulation of triglyceride-enriched very low density lipoproteins.

[The characteristics of the blood lipid transport system in the disabled with lost lower extremities]. / Osobennosti lipidnoi transportnoi sistemy krovi u invalidov s utrachennymi nizhnimi konechnostiami.

A comparative analysis of major blood lipoprotein values in 108 males aged 16-65 years with lower limbs amputations has shown a higher level of triglycerides (TG) and a reduced level of high density lipoprotein cholesterol (HDL C) in them than in control males with normal limbs. In the subgroup of patients who had undergone the amputation as a result of obliterative arterial disease, the TG level was the highest while HDL C the lowest; moreover, these values appeared to be the same as in the age-matched subgroup of patients with manifestations of atherosclerosis. In the subgroup of older men with posttraumatic lower limb amputations (aged 40-59 years) the TG and HDL C levels did not differ from the corresponding parameters in age-matched subgroup of healthy subjects, whereas young amputees (17-39 years) had the increased blood TG concentration and reduced level of HDL C and apolipoprotein AI. The conclusion is made: disability following limb amputation accompanied by restricted mobility, inadequate physical static efforts as well as by chronic psychological stress seem especially dangerous for young invalids because of associated lipoprotein profile changes which can be regarded as highly atherogenic.

[The effect of prolonged hypokinesia on hemodynamics and myocardial contraction in patients with ischemic heart disease after amputation of the extremities]. / Vliianie dlitel'noi gipokinezii na gemodinamiku i sokratitel'nuiu funktsiiu miokarda u bol'nykh ishemicheskoi bolezn'iu serdtsa posle amputatsii konechnostei.

Echocardiographic investigation revealed changes in central hemodynamics and myocardial contractility, associated with lasting hypokinesia, in coronary patients after the amputation of a limb that differed significantly from those recorded in patients with intact limbs. Amputation of a limb, lasting hypokinesia, physical overstrain, negative emotions, disorders of myocardial electric and contractile functions, central and peripheral hemodynamic disorders all contribute to the risk of coronary disease, myocardial infarction and death in post-amputation patients.

[Characteristics of the rheological properties of the blood, thrombocyte function and hemodynamics in ischemic heart disease after the amputation of the extremities of patients in a state of prolonged hypokinesia]. / Osobennosti reologicheskikh svoistv krovi, funktsii trombotsitov i gemodinamiki u bol'nykh ishemicheskoi bolezn'iu sredtsa posle amputatsii konechnostei, nakhodiashchikhsia v sostoianii dlitel'noi gipokinezii.

Ischaemic heart disease (IHD) in patients after amputation of the limbs runs a course with little manifest clinical symptoms, but with high risk of development of myocardial infarction with a lethal outcome. In patients after amputation of limbs there is a decrease of the blood stroke volume, increase of the total peripheral resistance and also marked disorders of the blood rheology and the function of platelets. In patients with IHD after amputation of the limbs for obliterating diseases of the vessels such changes are manifest in disorders of the microrheological properties of the blood (the rate of aggregation of red cell and the stability of red cell aggregates). Physical rehabilitation and prostheses in patients of this groups must be realized under careful cardiological control.