ABSTRACT
A decrease in heavy carbon isotope 13C content has been detected in atherosclerotically-altered aortic tissues. An extent of the isotope shift is increased with the intensification of sclerotic process in different regions of the aorta and depends on the patient's age. To explain the observed effect of isotope 13C content decrease in the altered aortic tissues it was suggested that the rates of biochemical conversions become considerably higher in sclerotically-altered tissues.
Subject(s)
Aortic Diseases/metabolism , Arteriosclerosis/metabolism , Carbon Isotopes/analysis , Aging/metabolism , HumansSubject(s)
Education, Medical, Undergraduate , Internal Medicine/education , Logic , Teaching/methods , Thinking , SiberiaSubject(s)
Circadian Rhythm , Mitosis , Seasons , Thymus Gland/cytology , Animals , Cell Count , Light , Male , Rats , T-Lymphocytes/cytologySubject(s)
Cytopathogenic Effect, Viral , Electromagnetic Phenomena , Mercury Poisoning , Animals , Chick Embryo , Culture Techniques , Enterovirus , Fibroblasts , Haplorhini , Humans , Influenza A virus , Kidney , MercurySubject(s)
Adaptation, Physiological , Cold Climate , Endocrine Glands/physiology , 11-Hydroxycorticosteroids/metabolism , 17-Ketosteroids/urine , Animals , Arctic Regions , Circadian Rhythm , Ecology , Ethnicity , Humans , Male , Seasons , USSRABSTRACT
Metabolic changes in newcomers to the Asiatic North have been revealed during their adaptation to a complex of the climatic and geographic factors of high latitudes. The changes were marked by making the most of lipids and less utilization of carbohydrates in energy supply to the adaptation processes. An important role of proteins in energy supply is discussed with emphasis on the changes in vitamin metabolism. The specificity of metabolic changes during adaptation is not taken into account in the nutrition program of the newcomers. This leads to the development of disadaptation shifts in the body. An important role of nutrition in adaptation of both the newcomers and aborigines of Siberia and North is suggested. The many-century experience gained in the nutrition of aborigines should be regarded in the newcomers' nutrition programs that are recommended to be based on protein-lipid diets.
Subject(s)
Cold Climate , Nutritional Physiological Phenomena , Adaptation, Physiological , Adult , Arctic Regions , Carbohydrates/blood , Diet , Emigration and Immigration , Ethnicity , Humans , Lipids/blood , Lipoproteins/blood , Seasons , Siberia , Vitamins/bloodABSTRACT
The study is concerned with ascertaining the role of UV radiation in distant intercellular interactions (DII) and the conditions resulting in "MIRROR" CYTOPATHIC EFFECT ("M" CPE). It has been found that the UV radiation-induced extreme state of the cells in a radiant culture produces distantly in an intact detector culture, which has only an optic contact with it, the cytopathic effect (CPE) as a repercussion of a specificity of morphological manifestations imprinted in the affected culture. UV preparadiation of the detector cells aids in manifestation of the "mirror" CPE.
Subject(s)
Embryo, Mammalian/cytology , Laryngeal Neoplasms/pathology , Ultraviolet Rays , Adenoviruses, Human/pathogenicity , Cells, Cultured , Cytopathogenic Effect, Viral/radiation effects , Female , Fibroblasts/microbiology , Fibroblasts/radiation effects , Humans , PregnancySubject(s)
Acclimatization , Cold Climate , 11-Hydroxycorticosteroids/blood , Arctic Regions , Blood Glucose/metabolism , Carotenoids/blood , Emigration and Immigration , Humans , Lipid Metabolism , Lipids/blood , Magnetics , Oxygen/blood , Peroxides/metabolism , Seasons , Siberia , Vitamin A/blood , Vitamin E/bloodSubject(s)
Acclimatization , Cold Climate , 11-Hydroxycorticosteroids/blood , Adolescent , Adult , Antioxidants , Arctic Regions , Blood , Emigration and Immigration , Female , Humans , Lipid Metabolism , Lipids/blood , Male , Peroxides/metabolism , Siberia , Time FactorsSubject(s)
Adaptation, Physiological , Cold Climate , Adolescent , Adult , Arctic Regions , Biophysical Phenomena , Biophysics , Circadian Rhythm , Erythrocytes/metabolism , Humans , Lipids/blood , Male , Seasons , Time Factors , USSRABSTRACT
The effect of adrenaline and hydrocortisone on the processes of free radical oxidation of lipids in rabbit erythrocytes was studied in experiment in vivo against the background of altered lipid metabolism. Adrenaline in a dose of 0.1 mg/kg and hydrocortisone in a dose of 5 mg/kg induced an increase in the amount of hydroperoxidase of fatty acids recorded by the changes of the UV spectrum. The data obtained served in confirmation of the fact that adrenaline and hydrocortisone possessed prooxidant properties, apparently mediated, this being connected with their fat mobilizing effects.
Subject(s)
Epinephrine/pharmacology , Erythrocytes/drug effects , Hydrocortisone/pharmacology , Lipid Metabolism , Animals , Antioxidants , Chinchilla , Diabetes Mellitus, Experimental/blood , Free Radicals , Oxidation-Reduction/drug effects , RabbitsSubject(s)
Phagocytes/physiology , Adaptation, Physiological , Animals , Bone Marrow Cells , Cathepsins/metabolism , Cell Differentiation , Deoxyribonucleases/metabolism , Endotoxins/pharmacology , Glucosidases/metabolism , Hepatectomy , Hormones/physiology , Humans , Hybridization, Genetic , Kupffer Cells/enzymology , Kupffer Cells/metabolism , Lipid Metabolism , Liver Regeneration , Lymphokines/physiology , Macrophages/cytology , Mice , Mice, Inbred C57BL , Mice, Inbred CBA , Rats , Ribonucleases/metabolismABSTRACT
Changes of the circadian rhythm of the general numbers of nucleus-containing cells and leucograms of peripheral blood in NZB mice with autoimmune spontaneous hemolytic anemia and in C57BL mice without visible disturbances in the system of immunostructural homeostasis were the most obvious in the white blood in NZB mice: a) disappearance of the circadian rhythm of the general number of nucleus-containing cells in peripheral blood owing to the inversion of circadian rhythm of the absolute number of neutrophiles; b) changes of circadian fluctuations of lymphocytes-neutrophiles ratio. The observed differences in circadian rhythms of hematological indices in NZB and C57BL mice seem to stem from insufficiency of adrenal cortex function and/or changes in functional state of hemopoietic tissue which can occur during the development of autoimmune processes.
