ABSTRACT
OBJECTIVE: This study is conducted to evaluate the efficacy and safety of using multifunctional intubation laryngeal masks with normal frequency jet ventilation in airway interventional therapy. METHODS: A total of 200 patients receiving airway interventional therapy were enrolled in this retrospective study and were divided into 2 groups (group M and group P) by doctors in our hospital to compare the effect of different laryngeal masks. Group M used common laryngeal masks and an anesthesia machine for positive pressure ventilation while group P took multifunctional intubation laryngeal masks and used a jet ventilator for normal frequency jet ventilation. The patients' mean arterial pressure, heart rate, arterial oxygen partial pressure (PaO2) and arterial carbon dioxide partial pressure (PaCO2), and the operation time, recovery score and the patients' and doctors' satisfaction levels were compared between the 2 groups. RESULTS: Both groups were hemodynamically stable, and their PaO2 levels were significantly higher before the operation than that during and after the operation (Pâ <â .05). Compared with group M, the PaCO2 level of group P was more stable both during and after the operation, and this difference was statistically significant (Pâ <â .05). There was no statistically significant difference in terms of the 2 group's operating time, recovery score, and patients' satisfaction levels (Pâ >â .05). However, the satisfaction levels of doctors in group P were higher than that in group M, and this difference was statistically significant (Pâ <â .05). CONCLUSION: As statistics show, the intraoperative hemodynamics and PaO2 and PaCO2 levels were stable, and patients, surgeons and anesthesia operators were satisfied. Therefore, it is feasible to apply multifunctional intubation laryngeal masks with normal frequency jet ventilation in airway interventional therapy and it is a safe and ideal way to ensure ventilation.
Subject(s)
High-Frequency Jet Ventilation , Laryngeal Masks , Humans , Retrospective Studies , Blood Gas Analysis , OxygenABSTRACT
A chemically diverse library of benzimidazole-azo-phenol derivatives was efficiently prepared and screened for their antifungal activities against five phytopathogenic fungi. Some compounds exhibited potent antifungal activities. As compared with a commercially available agricultural fungicide, hymexazol, especially compound V-5 showed the most promising broad-spectrum antifungal activities against five phytopathogenic fungi. The EC50 values of V-5 against F. graminearum, A. solani, V. mali, B. cinerea, and C. lunata were 0.09, 0.08, 0.06, 0.07, and 0.11 µmol/mL, respectively.
Subject(s)
Azo Compounds/chemical synthesis , Benzimidazoles/chemical synthesis , Fungicides, Industrial/chemical synthesis , Phenols/chemical synthesis , Alternaria/drug effects , Alternaria/growth & development , Azo Compounds/pharmacology , Benzimidazoles/pharmacology , Botrytis/drug effects , Botrytis/growth & development , Fungicides, Industrial/pharmacology , Fusarium/drug effects , Fusarium/growth & development , Magnetic Resonance Spectroscopy , Microbial Sensitivity Tests , Oxazoles/pharmacology , Phenols/pharmacology , Plants/microbiology , Saccharomycetales/drug effects , Saccharomycetales/growth & development , Sordariales/drug effects , Sordariales/growth & development , Structure-Activity RelationshipABSTRACT
A series of 2-(N-arylsulfonylindol-3-yl)-3-aryl-1,3-thiazinan-4-one derivatives were synthesized and evaluated in vitro against seven phytopathogenic fungi, namely Fusarium graminearum, Alternaria solani, Fusarium oxysporium f. sp. vasinfectum, Alternaria brassicae, Valsa mali, Alternaria alternata, and Pyricularia oryzae. Among all derivatives, especially compound 4j exhibited a potential antifungal activity against four phytopathogenic fungi.
