1.
Chinese Journal of Experimental and Clinical Virology
; (6): 72-74, 2006.
Article
in Chinese
| WPRIM (Western Pacific)
| ID: wpr-305521
ABSTRACT
<p><b>BACKGROUND</b>To investigate epidemiology and HLA typing of highly exposed to HIV but persistently seronegative subjects (HEPS) in commercial blood donors in China.</p><p><b>METHODS</b>This was a cohort study for epidemiologic characteristics of highly exposed but persistently seronegative subjects. PCR with sequence-specific primer and PCR-SSP for HLA typing were applied.</p><p><b>RESULTS</b>Eight HEPS were identified. Compared HLA typing with seropositive couple, high frequency of HLA-a24, HLA-B40 genotyping was observed.</p><p><b>CONCLUSION</b>Highly exposed to HIV but persistently seronegative subjects in commercial blood donors in China had high frequency of HLA-A24 and HLA-B40 genotype.</p>