ABSTRACT
Drug-induced acute interstitial nephritis (AIN) is a rare, potentially correctable cause of acute renal failure. Early recognition and appropriate therapy are essential to its management. Several drugs have been associated with the development of AIN, including antibiotics and nonsteroidal antiinflammatory, agents, all with characteristic mechanisms of toxicity.
Subject(s)
Nephritis, Interstitial/chemically induced , Acute Disease , Anti-Bacterial Agents/adverse effects , Anti-Infective Agents/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Fluoroquinolones , Humans , Lactams , Nephritis, Interstitial/diagnosis , Nephritis, Interstitial/drug therapy , Time FactorsABSTRACT
1) IAV infection seems to trigger acute renal allograft rejection frequently, especially in the first few months post-transplant, and these rejections are severe with a high rate of ultimate graft loss; 2) seroconversion occurred in most cases despite high dose steroids; 3) the course of IAV was prolonged and associated with a high incidence of complications in patients on high dose steroids.
