A Clinical Study of Malignant Sino-Nasal Tumors.

The sino-nasal cavities represent an anatomical region affected by a variety of tumors with clinical, etiological, genetic and pathological features, which are distinct from tumors commonly encountered in the area of head and neck cancers. We have undertaken this study with the aim of assessing clinical profile, various treatment modalities and outcome of patients with malignant sino-nasal tumors. In this prospective study of two years, done in a rural tertiary care hospital of India, 40 patients with malignant neoplastic tumors of nasal cavity, sinuses and nasopharynx were analyzed for their clinic-pathological and radiological profile and surgical management. The age range found was 10-78 years. There was a significant male preponderance with 23 (57.5%) male patients. Most common histological type seen in our study was Squamous cell carcinoma amongst 32 (80%) of cases. Maximum number of patients were managed with combination therapy of Surgery and Radiotherapy i.e. in 21 patients (52.5%). Multimodality treatment has been deemed the most efficacious choice of treatment which would improve disease free survival for the patients.

A Study of Anatomical Variations in the Nasal Cavity in Cases of Chronic Rhinosinusitis.

Chronic rhinosinusitis is very common disorder encountered in general population. Anatomical variations in the nasal cavity are mainly responsible for improper drainage and subsequent chronic rhinosinusitis. Present study is crosssectional and observational study undertaken at ENT department of tertiary care hospital. 200 cases of chronic rhinosinusitis fulfilling inclusion criteria were evaluated for various anatomical variations in the nasal cavity using diagnostic nasal endoscopy and computed tomography. Present study of 200 cases showed male preponderance M: F ratio 1:0.56. Most cases (79.5%) belonged to age group 11-50. Nasal obstruction was presenting complaint in 90% cases. 78% cases had septal deviation. 20% had septal spur. 32% cases had enlarged inferior turbinate, 9% had paradoxical middle turbinate, 13% had enlarged middle turbinate, 1% had bifid middle turbinate. 12% had pneumatised middle turbinate. 7% had enlarged uninate process, 1.5% cases had hypoplastic uncinate process and 7% had enlarged ethmoidal bulla. 45% cases showed oval sphenoid ostium while 31% showed circular and 8% slit like opening. Agger nasi cells were present in 82% cases. All 200 cases had anatomical variations in nasal cavity so it can be concluded that these are responsible for chronic rhinosinusitis.

Comparative Study of Outcome of Type 1 Tympanoplasty in Dry and Wet Ear in Tertiary Care Hospital.

Chronic suppurative otitis media is very common otological disease in general population. Persistent wet ear produces dilemma for ENT surgeons whether to go ahead with tympanoplasty or not. Present study compare outcome of type 1 tympanoplasty in both wet and dry ear. Present study is randomized, prospective, Interventional type of study carried in ENT department of tertiary care hospital over period of 18 months. Total 62 cases fulfilling study criteria were included in the study, which were equally divided in dry and wet group. All cases underwent type 1 tympanoplasty. Temporalis fascia was used as graft material in all cases. Most of the patients in both dry and wet group belonged to the age group between 21 to 30 (40.32%). 26 (41.94%) were males and 36 (58.06%) were females. Male: Female ratio was 1:1.38. After 12 weeks 27 (87.10%) cases of dry group and 20 (64.52%) cases of wet group had significant hearing improvement and in dry group 28 (90.32%) cases had intact graft while in wet group 23 (74.19%) cases had intact graft. According to the statistical analysis, in current study, there is no significant differences between the success rates of wet and dry ears, either in terms of graft uptake or the hearing improvement, thus it can be concluded that the presence of minimal ear discharge at the time of surgery does not affect the success rate of type 1 tympanoplasty.

Study of Clinicopathological Presentation and Management of Malignant Tumours of the Ear and Temporal Bone at Tertiary Care Cancer Hospital.

Tumors of the ear can be benign or malignant. They can occur on the external ear or in the ear canal, the middle ear, and inner ear. Tumors in different areas of the ear behave differently. They are rare which causes several problems in diagnosis and appropriate treatment. The purpose of this study was to analyze retrospectively the patients with malignant neoplasm of the ear. The main objectives of this study were to study the clinicopathological presentation of ear and temporal bone malignancy and to study the management of different types of malignancy of ear and temporal bone. This study is conducted at our tertiary care cancer hospital from Feb 2015 to Jan 2020. This study includes 15 patients treated for malignancy of the external and middle ear. The entire patient was thoroughly examined for malignancy. Details ENT examination was done. History of smoking and tobacco chewing asked. The patient factors considered in this study were age, sex, diagnosis, treatment (surgery, radiotherapy, and chemotherapy), complications, follow-up, and recurrence. This study includes [n = 15] patients. Due to a variety of malignant lesions of the ear and temporal bone they were classified into two groups, Superficial location lesions [n = 5] 3 of disease limited to pinna and 2 cases of primary of parotid origin involving pinna. Deep location involving external auditory meatus and middle ear [n = 12]. In this study of [n = 15] cases lowest age was 18 years. male and highest age was 75 years. male and most common age group was 56-65 years in which [n = 7] patients present. In this study we studied [n = 11] male patients and [n = 4] female patients. The most common symptom present was ear discharge [n = 8], the next common symptom was hard of hearing [n = 7]. A less common symptom was facial weakness [n = 3]. In sign, mastoid tenderness was commonest in [n = 5], and less common was facial palsy in [n = 3]. In our study of [n = 15] patients we did lateral temporal bone resection in [n = 5] patients, wide local excision of lesion in [n = 4] patients, lateral temporal bone resection with postero-lateral neck dissection with PMMC flap done in [n = 2] patients. In our study of [n = 15] cases of ear malignancy most common histopathology is squamous cell carcinoma [n = 12] cases, least were basal cell carcinoma [n = 1], melanoma [n = 1], and Rhabdomyosarcoma [n = 1]. Malignant tumors of the ear and temporal bone are rare. Neoplasm's of the external and middle ear constitutes a group of various histopathological and clinical tumors that differ in diagnostic difficulties, treatment, and prognosis. Surgery is the mainstay of treatment followed by reconstruction. Radiotherapy and chemotherapy play an adjuvant role in post-operative management in the high-risk category. Prognosis is worst as the tumor stage advances. And most of the cases diagnosis was often made in the advanced stage especially for middle ear tumors that diminished the possibility of effective treatment.

Cryosurgery Vs Trichloroacetic Acid Chemical Cautery for the Treatment of Hypertrophied Nasal Turbinate: A Comparative Study.

INTRODUCTION: The Study Aimed To Compare The Results of Cryosurgery With Trichloroacetic Acid Chemical (TCA) Cautery For The Treatment of Hypertrophied Nasal Turbinates. MATERIALS AND METHODS: This was a prospective study of 70 patients with nasal obstruction due to hypertrophied nasal turbinates who were randomly divided in 2 groups of 35 each. In group 1, patients underwent inferior nasal turbinate reduction by cryosurgery and in group 2 patients with cautery by 50 % TCA. The patients were evaluated using SNOT-20 score pre and postoperatively on 6th month. RESULTS: Significant improvement in symptoms was seen in 28 patients (80 %) in group 1 and in 10 patients (28.57%) in group 2..Improvement in average SNOT Score after cauterization of hypertrophied nasal turbinates by cryosurgery was from 55(severe) to 16(mild) and by TCA was from 54(severe) to 32(mod) in 6 months and this was statistically significant (P<0.001). Complications like bleeding, scarring, infection and adhesion formation were more with TCA than that of cryosurgery group and among these complications scarring was statistically significant (P =0.003). CONCLUSION: The use of cryosurgical treatment for hypertrophied nasal turbinates is a safe, curative method as compared to that of TCA cautery which is less curative and with more complications.

Use of Latissimus Dorsi Myocutaneous Island Flap for Pharyngeal Reconstruction in Setting of Postoperative Wound Infection in Salvage Laryngectomy.

Salvage laryngectomy frequently associated with more postoperative complication as compared with primary total laryngectomy. It carries a high risk of postoperative infection with reported rates of 40-61%. Problem related to local wound healing, especially development of pharyngo-cutaneous fistula constitutes the most common postoperative complication in these patients. In setting of treatment failure and gross extra laryngeal disease with fungating wound with infection, the situation even get worse while considering patient for salvage total laryngectomy. Postradiotherapy, poor blood supply of skin in irradiated portion adds extra pinch of salt in poor wound healing. We are here reporting case of management of salvage laryngectomy patient who had severe postoperative infection causing series of flap loss and pharyngeal leak in setting of preoperative gross extra laryngeal disease with skin involvement. In the present article, we were able to manage the case with PMMC and latissimus dorsi myocutaneous flaps.

Buccal Fat Pad a Forgotten Option of Reconstruction in Oral Cancer.

The buccal fat pad (BFP) originally described as an anatomic structure without any obvious function. For long period it was considered to be surgical nuisance. However during the last four decades buccal fat is successively used tool for maxillofacial surgery for reconstruction of small to medium sized acquired or congenital soft tissue and bony defect in oral cavity. The aim of present article is to review the database available regarding BFP including its anatomy, clinical usage in oral malignancy as tool of reconstruction after ablative procedures it's success and its adoptability with other loco-regional flap for oral reconstruction in different scenario and our experience with it in tertiary cancer centre in India.

Immature Teratoma of Nasal Septum: A Case Report.

INTRODUCTION: Teratomas are neoplastic tumors derived from totipotent germ cells containing a wide assortment of tissues originating from all three germ cell layers. Teratomas can be mature or immature depending on the presence of immature tissues; typically neuroepithelial tissue. Immature teratomas can be oncologically benign or malignant, and can be divided into three grades with increasingly aggressive biological behavior. The most common site for this tumor is the sacrococcygeal region. The nasal septum is an exceptionally rare site for immature teratomas, with very few cases reported. CASE REPORT: We discuss a 14-year-old male patient with a left nasal mass which, on histopathological examination, turned out to be a Grade-3 immature teratoma. Imaging revealed the mass to be confined in the left nasal cavity with erosion of the anterior skull base. During endoscopic excision, the tumor was seen extending intracranially but remaining extradurally. Complete resection was achieved, albeit with mild cerebrospinal fluid (CSF) leakage, which was closed successfully. The patient was subjected to adjuvant chemotherapy. A regular follow-up of 2 years showed no recurrence. CONCLUSION: The purpose of this report is to document the first case of a high-grade immature teratoma arising from the nasal septum with intracranial extension, as well as the efficacy of combined endoscopic resection and adjuvant chemotherapy for this pathology.

A study of tumours giving rise to unilateral proptosis.

Study of distribution, clinical features, radiological features, histopathological aspects, management and outcomes of tumours giving rise to unilateral proptosis. This is a prospective study including 40 patients with benign and malignant tumours of orbital, paraorbital and other sites giving rise to unilateral proptosis. Final diagnosis was made following detailed radiological and histopathological examination. Then, treatment modality was decided, which included surgery, radiotherapy, chemotherapy or required combination. Proptosis was measured by simple/plastic ruler exophthalmometry method. The maximum number of cases 8(20%) were in age group 31-40 years. The youngest patient was 4 year old and the oldest was 80 years. M:F ratio was 1.85:1. Malignant tumours were 32(80%) and benign tumours were 8(20%). 12 cases were having 3 mm proptosis (minimum) and one case having 18 mm (maximum). Only 4(10%) orbital tumours were responsible for unilateral proptosis. Paraorbital tumours 34(85%) was the major cause for unilateral proptosis and 2(5%) were from distant sites. Surgery was the mainstay of treatment 14(35%), followed by combined (surgery + radiotherapy) 5(12.5%), chemotherapy 4(10%), There was 4(10%) mortality, 16(40%) improved 3(7.5%) had same status and 17(42.5%) deteriorated. Thus nasal obstruction is the commonest ENT presenting complains in these patients. The major cause of unilateral proptosis was found to be paraorbital tumours (34%). Thus, a case of proptosis should never be ignored but a thorough ENT and ophthalmic examination is necessary. As malignancy is one of the major cause of unilateral proptosis catching and treating them early will reduce mortality.