ABSTRACT
Gas liquid chromatography was used to study and compare the changes in pentrane and halothane concentrations in the blood of patients with general surgical diseases under the conditions of monopentrane and combined (pentrane plus nitrous oxide) anesthesia (19 children aged 1-14 years), monohalothane anesthesia with different types of premedication (18 children aged 6-12 years) and with different types of the general anesthesia maintenance (24 patients aged 20-52 years). The use of combined anesthesia and premedication with suppositories containing phentanyl, methacin and etaperazine under the conditions of monohalothane anesthesia makes it possible, upon the attainment of stage III1 anesthesia, to reduce the concentration of the fluorine-containing anesthetics in the venous blood of the children by 1.7-1.8 times on an average. The maintenance of the general anesthesia by subanesthetic concentrations of a mixture of halothane, pentrane, nitrous oxide and phentanyl provides for adequate general anesthesia with substantially reduced concentrations of the fluorine-containing anesthetics in the arterial and venous blood of patients at the main stage of surgical intervention: halothane concentration is reduced 1.6 and 1.7-fold, that of pentrane 2.6- and 3.6-fold, respectively.
Subject(s)
Anesthetics/blood , Halothane/blood , Methoxyflurane/blood , Adolescent , Adult , Anesthesia, General , Anesthesia, Inhalation , Child , Child, Preschool , Chromatography, Gas/methods , Female , Humans , Infant , Kinetics , Male , Middle Aged , Preanesthetic Medication , Surgical Procedures, Operative , VeinsSubject(s)
Chromatography, Thin Layer/instrumentation , Lipids/blood , Adolescent , Adult , Child , Chromatography, Thin Layer/methods , Evaluation Studies as Topic , Female , Gels , Humans , Male , Middle Aged , Silicon DioxideSubject(s)
Fatty Acids/analysis , Chromatography, Gas , Fatty Acids/blood , Humans , Methods , MethylationSubject(s)
Drainage , Lipid Metabolism , Peritonitis/metabolism , Thoracic Duct/surgery , Acute Disease , Humans , Lymph/metabolism , Postoperative Period , Time FactorsSubject(s)
Anesthesia, General/methods , Halothane/blood , Methoxyflurane/blood , Adult , Arteries , Blood Pressure/drug effects , Cholecystectomy , Clinical Trials as Topic , Electroencephalography , Female , Fentanyl , Gastrectomy , Humans , Male , Middle Aged , Nitrous Oxide , VeinsABSTRACT
The clinical development, changes of the rheological blood properties and lipid metabolism were analysed in 70 patients with acute and subacute hemorrhagical infarctions into the hemispheres. Two clinical types in the development of hemorrhagical brain infarctions are described. The rheological blood properties and lipid metabolism had certain differences in comparison to patients with hemispheric hemorrhagical and ischemic strokes. They were also changed depending upon the age and duration of the illness. The pathogenesis of the changes detected is substantiated and their significance for microhemocirculation in patients with hemorrhagical brain infarctions is discussed.
