ABSTRACT
Spectral analysis of the heart rate variability can be used as a measure of baroreflex sensitivity in ketamine anesthetized rats. Stimulation of delta1-receptors with phenylephrine (0.01 mg/kg, i.v.) results in a rise of the strength of heart rate regulation, principally in the low frequency band. Maximal deviations of spectral indexes from basal level were observed on 4-8 min for low (0.2-1 Hz) and high (1-3 Hz) frequencies bands and on 10-15 min for very low (0.08-0.2 Hz) frequency band after phenylephrine injection.
Subject(s)
Baroreflex/physiology , Heart Rate/physiology , Adrenergic alpha-Agonists/pharmacology , Analysis of Variance , Anesthesia , Animals , Baroreflex/drug effects , Electrocardiography , Heart Rate/drug effects , Male , Myocardial Contraction/drug effects , Myocardial Contraction/physiology , Phenylephrine/pharmacology , RatsABSTRACT
A clinical case is submitted of development in a female patient of recurring thromboembolism of small branches of the pulmonary arteries preceding the clinical manifestations of a disease. Subsequently the above female patient was diagnosed as having developed carcinoma of gallbladder. An item of information is given concerning the syndrome of hypercoagulation and development of thromboembolism in malignant tumors.
Subject(s)
Carcinoma/complications , Gallbladder Neoplasms/complications , Pulmonary Embolism/complications , Blood Coagulation Disorders/complications , Female , Humans , Middle Aged , Secondary PreventionABSTRACT
A rare clinical case is reported of a patient presenting with glucose-6-phosphatase deficiency (Gierke's disease). Shown in the advanced stage of the disease is the polyorgan involvement. The report contains a brief review of relevant medical literature concerning etiology, pathogenesis, clinical picture, diagnosis of von Gierke's disease.
Subject(s)
Glycogen Storage Disease Type I/diagnosis , Adult , Glycogen Storage Disease Type I/pathology , Humans , MaleABSTRACT
Enrolled in the present study were 58 patients with acute glomerulonephritis, 58 with chronic glomerulonephritis and 16 controls. Chronic glomerulonephritis patients demonstrated a significant decrease in the amplitude in the first heart sound and increase in the amplitude of the second sound. The third and fourth sounds were detected in 61 patient with glomerulonephritis. There was a striking increase in the frequency of their emergence in those cases presenting with heart failure.
