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Strahlenther Onkol ; 182(1): 1-8, 2006 Jan.
Article in English | MEDLINE | ID: mdl-16404514

ABSTRACT

PURPOSE: To compare tests for intestinal function with clinical scores after abdominal irradiation. PATIENTS AND METHODS: At the Department of Radiotherapy, Erfurt, Germany, intestinal changes were studied in 91 patients receiving abdominal radiotherapy between 1992 and 1996. Conventional fractionation (1.8-2 Gy per fraction, total doses 30.6-62.5 Gy) was applied. Before and at weekly intervals during radiotherapy, the clinical response was scored according to RTOG/EORTC for the upper and lower gastrointestinal (GI) tract. Resorption tests for vitamin B(12) and D-xylose were performed before the onset and immediately after treatment. RESULTS: The clinical response displayed a well-defined dose-effect relationship with grade 1 effects in 5% and 50% of the patients at about 10 Gy and 50 Gy, respectively. For grade 2 reactions, 5%- and 50%-effective doses were 20-30 Gy and 60-80 Gy. Effects in the upper and lower GI tract were highly correlated. Changes in body weight did not show a correlation with other clinical symptoms. Changes in resorption also displayed a significant dose effect. However, no correlation was found with the clinical symptoms in the individual patient. CONCLUSION: In the present study, the clinical manifestation of intestinal side effects according to RTOG/EORTC criteria was reflected by neither the vitamin B(12) nor by the D-xylose resorption test. Hence, these tests cannot be regarded as useful for objective quantitation of intestinal radiation injury.


Subject(s)
Intestines/radiation effects , Radiation Injuries/diagnosis , Radiotherapy/adverse effects , Abdomen/radiation effects , Adolescent , Adult , Aged , Dose Fractionation, Radiation , Dose-Response Relationship, Radiation , Female , Hodgkin Disease/radiotherapy , Humans , Intestinal Absorption/radiation effects , Kidney Neoplasms/radiotherapy , Lymphoma, Non-Hodgkin/radiotherapy , Male , Middle Aged , Prospective Studies , Radiotherapy Dosage , Rhabdomyosarcoma/radiotherapy , Seminoma/radiotherapy , Stomach Neoplasms/radiotherapy , Testicular Neoplasms/radiotherapy , Time Factors , Vitamin B 12/pharmacokinetics , Xylose/pharmacokinetics
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