ABSTRACT
Previous reports proposed that the IgM anti-dsDNA antibody is protective for lupus nephritis. In this cross-sectional study, we aimed to compare clinical features of systemic lupus erythematosus (SLE) patients positive for IgG anti-dsDNA alone with those presenting both IgG and IgM anti-dsDNA. Anti-dsDNA antibodies, urinary examination and complement levels were assessed in the day of appointment. IgG and IgM anti-dsDNA antibodies were detected by indirect immunofluorescence. Fifty-eight SLE patients (93.1% female, 81% European-derived, mean age 42.8±14.7 years, mean duration of disease 10.9±8 years) positive for IgG anti-dsDNA entered the study. Of those, 15 were also positive for the IgM anti-dsDNA isotype. The group with both isotypes showed significant less frequency of active nephritis (sediment changes and proteinuria) when compared to patients with IgG anti-dsDNA alone (6.7% versus 34.9%, p=0.046). These data suggest a nephroprotective role for IgM anti-dsDNA and a distinct biologic behavior for this isotype in SLE.
ABSTRACT
Osteopoikilosis (OPK) is a rare, benign, and asymptomatic bone dysplasia that is developed during childhood and persists throughout life. This condition is generally found incidentally on plain radiographies made by other reasons. The main differential diagnosis is osteoblastic metastasis. So, OPK must be in differential diagnosis when bone lesions are identified on plain radiograph to avoid alarming the patient with more serious disease and misdiagnosis. In this paper, we review the clinical manifestation, pathophysiology, diagnosis, and treatment of OPK.
Subject(s)
Analgesics/therapeutic use , Osteopoikilosis/diagnosis , Osteopoikilosis/drug therapy , Adult , Humans , Male , Osteopoikilosis/physiopathologyABSTRACT
Lupoid sclerosis (LS) is a controversial entity, comprising features of both systemic lupus erythematosus and multiple sclerosis. Diagnostic criteria are a matter of debate, as well as the role of antinuclear and antiphospholipid antibodies. In this review, clinical and laboratory findings of LS available on Pubmed up to date are discussed.
Subject(s)
Antibodies, Antinuclear/immunology , Antibodies, Antiphospholipid/immunology , Lupus Erythematosus, Systemic/immunology , Multiple Sclerosis/immunology , Antibodies, Antinuclear/blood , Antibodies, Antiphospholipid/blood , Humans , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/pathology , Multiple Sclerosis/complications , Multiple Sclerosis/pathology , PubMedABSTRACT
Abdominal angiostrongyliasis (AA) is a disease caused by Angiostrongylus costaricensis, a nematode that can infect humans accidentally through the ingestion of larvae. Worms live inside intestinal small vessels and can lead to gastrointestinal symptoms and bowel necrosis in otherwise healthy patients. Therefore, abdominal angiostrongyliasis may be important in the differential diagnosis with systemic vasculitides and other rheumatic diseases with vascular involvement. We report a case of abdominal angiostrongyliasis in an 18-year-old woman presenting with necrosis of the terminal ileum.
Subject(s)
Abdominal Pain/diagnosis , Abdominal Pain/parasitology , Angiostrongylus/isolation & purification , Rheumatic Diseases/diagnosis , Strongylida Infections/diagnosis , Adolescent , Animals , Diagnosis, Differential , Female , Humans , RheumatologyABSTRACT
Lupoid sclerosis (LS) is a polemic entity. LS comprises features of both systemic lupus erythematosus (SLE) and multiple sclerosis (MS). Diagnostic criteria are a matter of debate, as well as the role of antinuclear and antiphospholipid antibodies. We here report 5 cases whereby LS could be postulated. Clinical and laboratory findings are discussed, and an updating of the literature on LS is brought about.
A esclerose lupóide é uma entidade polêmica. A afecção engloba achados de ambos: lúpus eritematoso sistêmico e esclerose múltipla. Os critérios diagnósticos são matéria de debate, assim como o papel de anticorpos antinucleares e antifosfolípides. Reportamos aqui cinco casos nos quais o diagnóstico de esclerose lupóide foi postulado. Os achados clínicos e laboratoriais são discutidos, e uma atualização da literatura acerca da esclerose lupóide é efetuada.
Subject(s)
Humans , Female , Adult , Antibodies, Antinuclear , Antibodies, Antiphospholipid , Multiple Sclerosis/diagnosis , Lupus Erythematosus, Systemic , Multiple SclerosisABSTRACT
Os autores fazem uma revisão bibliográfica sobre a etiologia, epidemiologia, diagnóstico e manejo da colite pseudomembranosa
