[The efficacy of using low doses of immunomodulators for treating experimental tumors]. / Effektivnost' primeneniia malykh doz immunomoduliatorov dlia lecheniia éksperimental'nykh opukholei.

The data about the ability of various substances to cause definite reactions in biological objects are adduced, and, in particular, about the efficacy of a small doses of antitumoral chemopreparations in experiment. The results of investigation of the application efficacy of various doses of immunomodulating agents, such as arbisol, nucleoplat, the substrate from gram-negative bacteria Yersinia enterocolitica, antitumoral vaccine from the tumoral cells are presented for the cancer chemotherapy. While application of super-small doses of an antitumoral vaccine there was noted statistically significant inhibition of tumoral growth.

[Immune reaction to the heterologic test-antigen in mice with anti-cancer vaccine]. / Immunnyi otvet na geterologicheskii test-antigen u myshei, kotorym vvodili protivoopukholevuiu vaksinu.

The stimulated influence of the antitumoral vaccine, prepared with the help of filtrate of the Bacillus mesentericus AB-56 or the antibiotic, extracted from it, on the immune answer to heterologic test-antigen (ram erythrocytes) was established. While the vaccine injection to laboratory animals with developing tumor their capacity to resist to the tumors was rising up.

[Results and the prospects of use of the new chemical preparation polyplatillene with antineoplastic and antiviral properties]. / Rezul'taty i perspektivy primeneniia novogo khimiopreparata poliplatillena, obladaiushchego protivoopukholevymi i protivovirusnymi svoístvami.

Ten years experience of the polyplatillene clinical application and experimental study is summarized. Results of treatment of 689 inner organs cancer patients stage IV, I-IV clinical groups. The advantages of polyplatillene versus others platinum group chemopreparations are shown. Manufacturing difficulties, mistakes and perils of the preparation application are pointed out. The direct dose-dependence of results is shown. Possibilities of polyplatillene application in biotechnology, radiology, virusology as a regulator of the cell division, viral replication and their interaction with a cell is shown.

[Antiviral action of the macromolecular derivative of the platinum with deoxyribonucleic acid in the treatment of patient with malignant liver neoplasm]. / Protivovirusnoe deistvie makromolekuliarnogo proizvodnogo platiny s dezoksiribonukleinovoi kislotoi u bolnykh so zlokachestvennoi opukholíu pecheni.

Results of the action of a preparation consisting of cis-dichlorodiammineplatinum and deoxyribonucleic acid combined in the saline balanced solution by means of the original technique on cytomegalovirus infection of patients with cancer of the liver are presented. Clearly pronounced antivirus activity of the preparation developed is noted.

[Preclinical trials of polyplatillen, the antitumor activity of a complex platinum compound with DNA on a leukemia P388 model in a HEp-2 cell culture (1)]. / Doklinicheskie ispytaniia poliplatillena, protivoopukholevaia aktivnost' kompleksnogo soedineniia platiny s DNK na modeli leikemii P-388 v kul'ture kletok HEp-2 (soobshchenie 1).

The authors studied the antitumour activity of a new complex platinum compound (DDP-DNA) in mice with leukemia P-388 and in cell culture. DDP-DNA was introduced intraperitoneally 24 hours after inoculation of 2 x 10(6) tumour cells. It was established that by its antitumour activity DDP-DNA was not inferior then DDP. The antiproliferative activity of nontoxic doses of the preparation in cell culture has been shown.

[Endovascular regional infusion therapy in the combined treatment of liver abscess]. / Endovaskuliarnaia regionarnaia infuzionnaia terapiia v kompleksnom lechenii abstsessa pecheni.

The comparative assessment of the effectiveness of endovascular regional infusion therapy (ERIT) in the complex of treatment of a hepatic abscess in 16 patients was carried out. In 12 patients, it was performed in combination with surgical intervention, in 4--as an independent method of treatment. In patients with a solitary hepatic abscess, it is expedient to include ERIT into the complex of therapeutic measures in combination with abscess puncture under ultrasound guidance. In presence of multiple abscesses of the liver, ERIT is a method of choice.

[Preclinical study of the general toxic effect of polyplatillen]. / Doklinicheskoe izuchenie obshchetoksicheskogo deistviia poliplatillena.

Toxic action of polyplatillen, a principally new platinum compound, was studied on laboratory animals and cell culture. When compared with cis-dichlorodiamminplatinum, the preparation is 10-fold less toxic in animals and 100-fold--in the cellular systems. Reversibility of damaging action of polyplatillen at "non-toxic" dosages conditions the perspectiveness of its further clinical trials.

[Use of polyplatillen in the treatment of stage IV malignant neoplasms]. / Primenenie poliplatillena dlia lecheniia zlokachestvennykh novoobrazovanii IV stadii.

Results of the use of polyplatillen--a preparation consisting of sodium nucleinate (deoxyribonucleic acid) and cisplatin combined in the saline balanced solution by means of the original technique--in cancer of the ovaries (198 patients), liver (62), pancreas (35), lungs (12), stomach (5) are presented. Clearly pronounced specific activity of the preparation developed is noted.

[Various methods to assay carbenicillin activity against Pseudomonas aeruginosa]. / Razlichnye metody pri opredelnii aktivnosti karbenitsillina v otnoshcenii Pseudomonas aeruginosa.

It was shown that the cultures of Pseudomonas aeruginosa were sensitive to 75-100 micrograms/ml and resistant to 25-50 micrograms/ml of carbenicillin when tested by the method of serial dilutions in the synthetic medium developed by the authors and in Jorgensen's medium. The cultures were incubated for 4 and 16 hours, respectively. The data did not confirm the resistance of the cultures to 25-75 and 100 micrograms/ml carbenicillin when it was determined with the serial dilution method in Pal's medium and the disk diffusion method, respectively. The advantages of the medium developed by the authors for testing P. aeruginosa sensitivity to carbenicillin are discussed.

[Effect of exogenous neoplasm DNA on the course of Swetz leukemia in non-inbred rats of different age groups]. / Vliianie ékzogennoi opukholevoi DNK na techenie leikoza Shwetsa u besporodnykh krys razlichnykh vozrastnykh grupp.

Experiments on 150 non-inbred white rats have shown that preliminary administration of high polymer native DNA isolated from Swetz leukemia tumor suppresses the tumor growth. Tumor DNA combined with BCG vaccine in young animals suppresses and in old ones stimulates the tumor growth. These results correlate with DNA and CIC content in the blood serum. Due to the tumor growth suppression the animals' life increases by 40%. Administration of BCG vaccine only does not prevent the development of tumor in usual terms.