Subject(s)
Digestive System Surgical Procedures/methods , Gastrointestinal Hemorrhage/surgery , Granulomatosis with Polyangiitis/complications , Jejunal Diseases/surgery , Adult , Anastomosis, Surgical , Constriction , Endoscopy, Digestive System/methods , Gastrointestinal Hemorrhage/etiology , Humans , Jejunal Diseases/etiology , MaleSubject(s)
Amebiasis/diagnosis , Gastric Mucosa/parasitology , Stomach Diseases/diagnosis , Stomach Diseases/parasitology , Adult , Amebiasis/drug therapy , Antiprotozoal Agents/therapeutic use , Biopsy , Diagnosis, Differential , Endosonography , Gastroscopy , Humans , Male , Metronidazole/therapeutic use , Stomach Diseases/drug therapyABSTRACT
PurposeThis was a collaborative study from the Ophthalmology and Gastroenterology departments of a tertiary care hospital, designed to investigate the local ocular surface parameters in patients with celiac disease (CD).MethodsFifty-six eyes of 28 patients with CD and 58 eyes of 29 healthy adult subjects serving as controls were evaluated. The Schirmer test, tear-film break-up time, and conjunctival impression cytology were performed in addition to a complete ophthalmological examination. Impression cytology specimens of each group were graded and scored in the range 0-3.ResultsThe 28 patients with CD consisted of 24 females (86%) and 4 males (14%). The mean age was 34.4±11.3 years (22-55 years). Tear-film break-up time and Schirmer test results were significantly lower in the study group than in the controls (P<0.05). Also, there was a significant difference between the groups for impression cytology grading scores (P=0.001).ConclusionsThe CD group showed a marked preponderance of females with an F/M ratio of six females per male, as reported in the literature. Tear-film functions and conjunctival surface epithelial morphology were significantly altered in patients with CD.
Subject(s)
Celiac Disease/complications , Conjunctiva/pathology , Cornea/pathology , Diagnostic Techniques, Ophthalmological , Dry Eye Syndromes/diagnosis , Sclera/pathology , Adult , Celiac Disease/diagnosis , Dry Eye Syndromes/etiology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Retrospective Studies , Severity of Illness Index , Tears/metabolism , Young AdultSubject(s)
Endoscopy/methods , Esophageal Fistula/surgery , Respiratory Tract Fistula/surgery , Suture Techniques , Aged , Carcinoma, Non-Small-Cell Lung/surgery , Esophageal Fistula/etiology , Esophagoscopy , Humans , Lung Neoplasms/surgery , Lymph Node Excision , Male , Pneumonectomy , Respiratory Tract Fistula/etiology , Suture Techniques/instrumentationABSTRACT
Local bone marrow (BM) renin-angiotensin system (RAS) affects physiological and pathological haematopoiesis, including erythropoiesis. In this study, quantitative expression of the messenger RNAs of the major RAS components--angiotensin-converting enzyme (CD143), renin and angiotensinogen--were measured in BM samples by quantitative real-time polymerase chain reaction, to evaluate the activity of local BM RAS in polycythemia rubra vera (PV) in comparison with normal erythropoiesis. The presence of CD143 was also investigated in the same BM samples by flow cytometry. Increased local synthesis of the major RAS components has been identified by demonstrating corresponding mRNAs in the BM of the patients with PV. Our findings indicate up-regulation of local BM RAS, together with down-regulation of the cell surface angiotensin-converting enzyme receptors, in the autonomous neoplastic clonal erythropoiesis of PV.