ABSTRACT
The excretion of three fluoroquinolones derivatives into the saliva were studied in animal experiments. Ofloxacin per os administered to rabbits was excreted into the saliva well, and maintained the therapeutic level long--about 7 hours. Pefloxacin and ciprofloxacin iv. administered to mice were similarly excreted into the saliva at therapeutic levels and retained the antibacterial level for about 4 hours.
Subject(s)
Anti-Infective Agents/pharmacokinetics , Ciprofloxacin/pharmacokinetics , Ofloxacin/pharmacokinetics , Pefloxacin/pharmacokinetics , Animals , Drug Evaluation, Preclinical , Mice , Rabbits , Saliva/chemistryABSTRACT
In rabbit experiments (n = 10) the salivary and serum levels of several antibiotics were studied after per os (clindamycin, erythromycin and lincomycin) and iv. (erythromycin) administration. Erythromycin was excreted into the saliva in a considerable degree (in 60-75% of the serum level) and displayed therapeutical levels for 5-6 hrs, whereas clindamycin and lincomycin reached in the saliva only 25-30% of the serum level and therapeutic levels were maintained only for 3 hours.
