Olfactory Function Assessment of Blind Subjects Using the Sniffin' Sticks Test.

OBJECTIVE: In recent years, a growing number of studies have focused on the olfactory abilities of blind individuals as well as their tactile and auditory senses. In this study, we aimed to investigate possible alterations in the sense of smell in early- and late-blind subjects as compared with sighted controls, using a Sniffin' Sticks test battery. STUDY DESIGN: Prospective clinical study. SETTING: Tertiary referral center. SUBJECTS AND METHODS: A total of 66 subjects were included in the study. The subjects were divided into 2 groups: blind subjects-who were then subgrouped as subjects with congenital blindness (n = 17) and those with acquired blindness (n = 16)-and sighted subjects (n = 33). We compared both congenitally and acquired blind subjects with sighted counterparts using the Sniffin' Sticks test for odor threshold, odor discrimination, odor identification, and total odor scores. RESULTS: The blind subjects were more successful than their sighted counterparts in odor discrimination and odor threshold tasks. There was no statistically significant difference between the blind participants and the sighted individuals in terms of odor identification value. Another important finding was that the difference between individuals with congenital blindness and those with acquired blindness was not significant in any of the parameters. CONCLUSION: This finding may suggest that odor discrimination and odor threshold in blind people were superior to those of controls. There was no difference in any of the results of tasks among congenital and acquired blind subjects.

Inflammatory cell patterns in the nasal mucosa of patients with idiopathic rhinitis.

BACKGROUND: Nonallergic rhinitis comprises many subgroups of rhinitis (vasomotor rhinitis, nonallergic rhinitis with eosinophilia syndrome, occupational rhinitis, idiopathic rhinitis, etc. in which its main feature is known to be free of allergy. We evaluate the cellular infiltrate of subjects with idiopathic rhinitis and compare them with allergic and control counterparts for detecting underlying pathophysiology. METHODS: Subjects selected from patients admitted to Istanbul University Medical Faculty between 2006 and 2009 were classified into idiopathic rhinitis (n = 16; mean age, 26.5 years), allergic rhinitis (n = 17; mean age, 31.1 years), and the control (n = 25, mean age, 28.8 years) groups. Inferior turbinate specimens were collected using Gerritsma forceps. Skin-prick testing was performed. Immunohistochemical detection was performed using B7 (chymase, clone CC1) and G3 (tryptase, clone AA1) primary antibodies for mast cells, human eosinophil major basic protein (clone BMK-13) for eosinophils, and immunoglobulin E (IgE) Ab-1 for mast and plasma cells in epithelium, superficial, and deep submucosa. RESULTS: We found significantly higher levels of mast cells within the different sites of nasal mucosa of allergic and idiopathic subjects compared with normal mucosa (p < 0.05). Additionally, a significant increase was observed in IgE(+) cells of the patients with allergic and idiopathic rhinitis compared with the controls (p < 0.05 for each) Eosinophils were significantly increased within the epithelium of allergic patients' mucosa. CONCLUSION: We seem to have supportive data about possible mechanisms of "idiopathic rhinitis" that suggests local allergic inflammation. The study results provided important information for further provocation and immunohistochemical studies analyzing the shared mechanism of allergic and idiopathic rhinitis.

Evaluation of factors concerning the olfaction using the Sniffin' Sticks test.

OBJECTIVE: This study aimed to research the normative values of olfactory function in the Turkish population using the Sniffin' Sticks test and to relate olfactory performance to age, sex, smoking, educational level, and the side examined. It also aimed to compare the results with other countries' normative values, especially Europe, using the same test and procedure. STUDY DESIGN: Prospective clinical study. SETTING: Tertiary referral center. SUBJECTS AND METHODS: This study was a prospective clinical trial conducted in a tertiary clinic. A total of 100 healthy subjects were included in the study. Of these, 50 were men and 50 were women. The mean (SD) age of the subjects was 37.7 (14.8) years (range, 18-77 years). RESULTS: Odor scores were lower than the scores of other countries, and the scores decreased significantly with age. There was no relationship between olfaction and sex or smoking. Subjects with a lower educational status had lower scores compared with the scores of median and highly educated subjects. CONCLUSION: This is the first study that evaluated the relationship between education level and olfaction. According to the results, the cultural differences, education level, and age seemed to influence odor scores. The Sniffin' Sticks test can be used to assess olfactory performance in a Turkish population, but identification of odors in this test battery may show variability because of local and cultural factors.

Comparison of the efficacy of nasal drop and nasal spray applications of fluticasone propionate in nasal polyps.

OBJECTIVES: We assessed the efficacy of different forms of fluticasone propionate in the treatment of bilateral nasal polyposis in adult patients. PATIENTS AND METHODS: This double-blind, randomized, parallel group study included 34 patients, aged 16 years or over, with a diagnosis of bilateral nasal polyposis. The patients were randomized to three groups to receive fluticasone propionate in the form of aqueous nasal spray 100 microg twice daily, or nasal drop preparation 400 microg once or twice daily for 12 weeks. Once every four weeks, nasal volumes were measured by acoustic rhinometry and polyp size was assessed by a 4-mm rigid endoscope. Clinical symptom scores were assessed once a week. RESULTS: The mean nasal polyp scores decreased significantly in all the groups (p<0.005). Total nasal volume did not improve significantly with the nasal spray. Although single daily nasal drop application increased total nasal volume significantly only at the end of treatment (p<0.05), increases with twice daily application were significant at 4, 8, and 12 weeks, compared to the baseline values and corresponding values of the other two groups (p<0.005). Nasal blockage and rhinitis symptom scores improved in all the groups (p<0.05), but the difference from the baseline was highest with twice daily nasal drop application. Smelling showed a significant improvement only with twice daily nasal drop application (p<0.05). In none of the groups did nasal discomfort scores differ significantly from the baseline at the end of treatment. CONCLUSION: Nasal drop preparation of fluticasone propionate given twice daily showed the highest efficacy in increasing total nasal volume, decreasing nasal polyp size, and improving smelling and nasal blockage.

Treatment of allergic rhinitis during pregnancy.

BACKGROUND: Allergic rhinitis (AR) affecting approximately 20-30% of women in childbearing age can be considered one of the most common group of medical conditions that complicate pregnancy. AR with symptoms of nasal obstruction, sneezing, and itching may require pharmacotherapy. However, there are concerns regarding the safety of different available agents that can be used during pregnancy with respect to both maternal and fetal well being. CONCLUSIONS: The best first-line approach in the management of AR is avoidance of allergens. If environmental modification is ineffective, then the pharmacologic agents should be chosen. For symptoms of rhinorrhea, sneezing, or itching, intranasal cromolyn, with its excellent safety profile, should be considered as first-line therapy. If cromolyn is ineffective or poorly tolerated, first-generation (e.g., chlorpheniramine and tripelennamine) and second generation (e.g., cetirizine and loratadine) antihistamines can be given. Intranasal steroids (e.g., beclomethasone dipropionate, and budesonide) can be added to first-line therapy especially for severe nasal obstruction. There are no epidemiological studies with newer intranasal steroids (e.g., flunisolide, triamcinolone acetonide, fluticasone propionate, and mometasone furoate) during the first trimester of pregnancy. Immunotherapy has not proven to be teratogenic and is clinically useful in improving symptoms. Oral and topical decongestants can be considered as second-line therapy, for short-term relief, when no safer alternative is available.

Synovial sarcoma: a rare tumor of larynx.

Synovial sarcoma is a soft tissue sarcoma of unknown histogenesis and occurs predominantly in the lower extremities of young adults. The head and neck is a relative rare location. There are about 10 cases with laryngeal localization in the literature. We present a 24 year-old male with an endolaryngeal mass. Incisional biopsy and the hemilaryngectomy material revealed a biphasic synovial sarcoma. One year later a local recurrence occurred. Tumor excision and neck dissection were performed. Radiotherapy was added. Six months later lung metastases was discovered on thoracic CT. The patient received chemotherapy for 6 courses. The metastases responded well to chemotherapy and the patient is now alive without tumor on radiological and clinical examination after 3.5 years of follow-up.

Body position and obstructive sleep apnea syndrome.

In adults, influence of body position on the occurrence of respiratory events during sleep is recognized, and increased numbers of respiratory events occur when the supine position is assumed.1-4 In 1985, Orr et al. showed that body position did not influence respiratory events during sleep in children.5 Recently, Fernandes do Prado et al. showed that children had a lower obstructive apnea hypopnea index (AHI) in supine position.6 Results of these two studies are different from others performed on adults. Moreover, upper airway abnormalities were not considered in these studies. The aim of the present study was to evaluate the effect of body position on obstructive respiratory events in children with different upper airway findings.

p21, p53, and p27 Kip1 alterations in benign and malignant tumors of sinonasal epithelium.

OBJECTIVE: The goal of this study was to investigate alterations of cell cycle-related molecules, including p27, p21, and p53, in inverted papillomas (IPs) and squamous cell carcinomas (SCCs) of the sinonasal epithelium. Study design Sixteen IPs and 6 SCCs of the sinonasal epithelium, surgically resected at Istanbul Faculty of Medicine, Department of Otorhinolaryngology, from 1992 to 2000 were immunohistochemically investigated (p27, p21, and p53). RESULTS: A significant decrease in p27 nuclear staining was observed for SCCs of paranasal sinus compared with inverted papillomas (P = 0.0072). In SCCs there was no association between p27 expression and the presence of keratinization and tumor grade. p21 and p53 expressions were not associated with IPs (dysplastic and nondysplastic) and SCCs. CONCLUSION: Reduced levels of p27 expression correlate with increased cell proliferation in tumors of sinonasal region. Our findings indicate that p27 immunohistochemistry can be recommended to analyze the dysregulation of cell kinetics in these tumors.

[Evaluation of hearing performance in cochlear implant patients]. / Koklear implantasyonlu hastalarda isitme performanslarinin karsilastirilmasi.

OBJECTIVES: To determine the speech perception levels of cochlear implant patients and to evaluate the possible effects of implant type, duration of deafness, and bacterial meningitis on the patients' hearing performance. PATIENTS AND METHODS: A three-section test battery on speech perception was administered to 21 cochlear implant patients (12 males, 9 females; mean age 25 years; range 9 to 40 years). The patients' performance was assessed with respect to single- or multi-channel implant design, duration of hearing loss, and etiologic factors of hearing loss. RESULTS: The overall mean success score was 74.6 (range 49-100). No significant difference was found between patients using single- or multi-channel implants. The mean score of 12 patients whose duration of hearing loss was below the average (8.2 years) was significantly higher than those of nine patients with a longer history of hearing loss (85.7 versus 59.6, p=0.001). Patients with meningitis-associated hearing loss exhibited a significantly lower performance than those presenting with other etiologic factors (61.9 versus 84.1, p=0.001). CONCLUSION: Early diagnosis and rehabilitation are essential to achieve better performance following cochlear implantation.

[The efficacy of laser-assisted uvulopalatoplasty in the treatment of snoring and obstructive sleep apnea]. / Horlama ve tikayici uyku apnesi tedavisinde laser-assisted uvulopalatoplastinin etkinliginin degerlendirilmesi.

OBJECTIVES: We evaluated the efficacy of laser-assisted uvulopalatoplasty in the treatment of snoring and obstructive sleep apnea syndrome (OSAS). PATIENTS AND METHODS: Laser-assisted uvulopalatoplasty was performed in 34 patients (30 males, 4 females; mean age 45.7 years; range 17 to 70 years) with simple snoring and mild OSAS. The patients were evaluated preoperatively and in the first and sixth months postoperatively with the use of the Epworth sleepiness scale, polysomnography, and snoring scores. A questionnaire was administered to assess patient satisfaction. RESULTS: All patients had decreased snoring. The quality of sleep increased in 79%. The clinical improvement seen in the first month continued through the sixth postoperative month. Satisfaction rates for the patients and their families were 88% and 85%, respectively. Significant decreases were found in the Epworth sleepiness scale (p=0.000) and visual snoring scores (p<0.001). In addition, postoperative desaturation indices decreased and minimal desaturation levels increased. However, no significant decreases occurred in the apnea/hypopnea index. No complications were encountered during and after operation. CONCLUSION: Laser-assisted uvulopalatoplasty has high efficacy in the treatment of snoring and mild OSAS, with such additional advantages as ease, low complication rate, and no need for hospitalization.

Expression of the the cyclin-kinase inhibitors p21(WAF1) and p27(Kip1) and the p53 tumor suppressor genes in adult-onset laryngeal papillomas.

Different types of human papilloma virus are known to be closely associated with laryngeal papillomas. On the other hand, the proliferation of epithelial cells is associated with various abnormalities in the mechanisms of cellular regulation. In this study, we detected the expressions of p53, p21 and p27 proteins in adult-onset laryngeal papillomas by immunohistochemical techniques. The objective of this study is to evaluate the expression of these factors in adult-onset laryngeal papillomas and to determine whether such expression is correlated with the existence of dysplastic epithelium covering the papillomas. Eighteen patients with adult-onset papillomas who were surgically treated at the Department of Otolaryngology at the University of Istanbul between January 1994 and December 1999 were included in this study. Anti-p21, -p27 and -p53 antibodies were used to perform immunostaining. Positive nuclear staining for p21 was detected in 14 of the 18 (78%) cases, especially in the parabasal layer. Also, in 78% of the cases, weak to strong immunoreactivity was observed for p27. In all cases, negative immunoreactivity was observed for p53 throughout the epithelium except for the basal and parabasal cells. A negative correlation was observed between the existence of dysplastic epithelium and p21 expression (P=0.02). In conclusion, variable p21 and p27 expression was detected by immunohistochemistry in our series of 18 cases of adult-onset laryngeal papillomatosis, and a statistically significant inverse correlation was detected between p21 expression and the existence of dysplastic epithelium covering the papillomas. Further prospective studies are warranted to determine the prognostic values of these variables and to evaluate their role in the pathogenesis of adult-onset laryngeal papillomas.

Treating allergic rhinitis in the athlete.

Allergic rhinitis may affect athletes like any other member of society. It is a major problem for the atopic athlete. Either perennial or seasonal, it may cause problems with nasal function depending upon the type and quantity of allergen exposure. Moreover, exposure to irritants, chemicals and air pollutants may exacerbate allergic rhinitis. In this patient group, special diagnostic and particularly therapeutic considerations are warranted for the disease. Treatment of the athlete should be based on two important principles: no medication given should be on any list of doping products and no medication used should affect the athlete's performance. Antihistamines, topical cromolyn, and topical steroids may be used to control allergic rhinitis without violating 'anti-doping' regulations.