[Lincomycin concentration in the blood and tissues when administered by electrophoresis in children with acute and chronic hematogenic osteomyelitis]. / Kontsentratsiia linkomitsina v krovi i tkaniakh pri vvedenii ego metodom élektroforeza u detei s ostrym i khronicheskim gematogennym osteomielitom.

Twenty five children suffering from acute and chronic hematogenic osteomyelitis were subjected to lincomycin therapy in addition to surgical and general tonic treatment. The antibiotic was administered by means of electrophoresis in 15 children and by means of electrophoresis together with intramuscular injections in 10 children. It was found that administration of the drug by means of electrophoresis 1 hour after its intramuscular injection provided the highest lincomycin levels in the bone cavity favourable for the disease treatment.

[Various methods of using lincomycin for treating acute and chronic hematogenic osteomyelitis in children]. / Razlichnye metody ispol'zovaniia linkomitsina dlia lecheniia ostrogo i khronicheskogo gematogennogo osteomielita u detei.

Comparative data on the treatment of 209 children with acute and chronic hematogenic osteomyelitis are presented; 128 patients hospitalized before 1974 were treated with antibiotics, mainly penicillin and streptomycin without sensitivity testing. From 1974 81 children were treated with lincomycin; 80 per cent of the isolates were sensitive to this antibiotic. In lincomycin therapy the method of electrophoresis on the disease focus, intrabone administration of the drug and administration of the drug into the bone cavity together with the blood clot during surgical interventions in cases with chronic hematogenic osteomyelitis were used. A marked decrease in the rate of the chronic forms of the disease was registered (from 77.2 to 8.8 per cent).