1.
Antimicrob Agents Chemother
; 51(3): 1099-101, 2007 Mar.
Article
in English
| MEDLINE
| ID: mdl-17178798
ABSTRACT
The effect of mefloquine on artesunate pharmacokinetics was assessed in 20 volunteers given artesunate for 3 days, followed > or =21 days later by combination therapy for 3 days. The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction.