The relationship between forgiveness and borderline personality symptomatology.

The relationship between forgiveness and borderline personality symptomatology has been rarely studied. Using a consecutive cross-sectional sample of 307 internal medicine outpatients and a survey methodology, we examined correlations between the Forgiveness Scale and borderline personality symptomatology as measured by the borderline personality disorder scale of the Personality Diagnostic Questionnaire-4 and the Self-Harm Inventory. Numerous forgiveness subscales as well as the composite Forgiveness Scale score demonstrated statistically significant relationships with both measures for borderline personality symptomatology, such that individuals with this personality pathology demonstrated lower scores on these forgiveness subscales. Findings indicate that among individuals with borderline personality symptomatology, there are numerous aspects of forgiveness that are significantly lower than in individuals without this symptomatology.

Bullying in childhood and religious/spiritual status in adulthood among internal medicine outpatients.

BACKGROUND: Bullying in childhood is ubiquitous and associated with a number of identified negative outcomes in both childhood and adulthood. However, the relationship between being bullied in childhood and religious/spiritual status in adulthood has never been explored. METHOD: Using a cross-sectional sample of 324 consecutive internal medicine outpatients and a survey methodology, we examined relationships between 'When you were growing up, were you ever a victim of bullying?' and (1) self-perceived extent of religiosity/spirituality and (2) religiosity/spirituality as assessed by scores on the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp-12). RESULTS: While bullying status in childhood was not related to either the self-perceived extent of religiosity or spirituality, it did evidence negative statistically significant relationships with seven of 12 FACIT-Sp-12 scales, as well as the overall composite score. CONCLUSIONS: According to these data, bullying in childhood is associated with lower religious/spiritual well-being in adulthood; however, this study was not designed to examine a causal relationship.

Abuse in childhood and religious/spiritual status in adulthood among internal medicine outpatients.

The relationship between abuse in childhood and religiosity/spirituality status in adulthood has been previously studied, but not in a medical sample or with the current study measure. Using a cross-sectional consecutive sample of 317 internal medicine outpatients, we asked participants, "As a child, were you the victim of either physical or sexual abuse?," and assessed religiosity/spirituality status with the Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp-12). We found that among the cohort with abuse in childhood, seven of twelve scales as well as the overall FACIT-Sp-12 score demonstrated statistically significant differences, with abused participants consistently evidencing lower religiosity/spirituality scores.

Perceptions of parental caretaking in childhood and religiosity/spirituality status in adulthood.

Relationships between parental caretaking quality in childhood and religiosity/spirituality in adulthood, which are the focus of the present study, have undergone limited study. Using a cross-sectional sample of consecutive internal medicine outpatients, we examined in 308 participants three aspects of their parenting experience (i.e., number of different caretakers, whether caretakers were biological parents or not, perceived quality of parental caretaking) and level of religiosity/spirituality over the past 12 months using the Functional Assessment of Chronic Illness Therapy-Spiritual Well-being Scale (FACIT-Sp-12). Current level of religiosity/spirituality did not correlate with the number of different caretakers or whether caretakers were biological parents or not. However, 6 of 12 FACIT-Sp-12 scales and the overall FACIT-Sp-12 score statistically significantly correlated with perceived quality of parental caretaking, with better parenting ratings associated with higher levels of self-reported religiosity/spirituality. Findings suggest that better parenting in childhood is associated with higher levels of certain aspects of current religiosity/spirituality in adulthood.

Religion/spirituality status and borderline personality symptomatology among outpatients in an internal medicine clinic.

OBJECTIVE: This study was designed to assess religion/spirituality (RS) status over the preceding 12 months in relationship to borderline personality symptomatology status. METHODS: Using a cross-sectional consecutive sample of internal medicine outpatients and a self-report survey methodology, we examined RS using the 12-item Functional Assessment of Chronic Illness Therapy-Spiritual Well-Being Scale (FACIT-Sp-12), and borderline personality symptomatology using two self-report measures, the borderline personality scale of the Personality Diagnostic Questionnaire-4 and the Self-Harm Inventory. RESULTS: The majority of FACIT-Sp-12 scales as well as the overall FACIT-Sp-12 score demonstrated an inverse relationship with scores on the individual measures for borderline personality symptomatology as well as a combined measure of such symptoms (individuals who scored positively on both measures). In other words, lower RS was identified in participants with higher levels of borderline personality symptomatology. CONCLUSIONS: According to findings, compared to participants without borderline personality symptomatology, those with such symptomatology evidenced statistically significantly lower RS on most study scales as well as the overall FACIT-Sp-12 score. This suggests that individuals with borderline personality symptomatology have lower overall levels of RS than individuals without this type of psychopathology.

YPEL3, a p53-regulated gene that induces cellular senescence.

Cellular senescence, the limited ability of cultured normal cells to divide, can result from cellular damage triggered through oncogene activation (premature senescence) or the loss of telomeres following successive rounds of DNA replication (replicative senescence). Although both processes require a functional p53 signaling pathway, relevant downstream p53 targets have been difficult to identify. Discovery of senescence activators is important because induction of tumor cell senescence may represent a therapeutic approach for the treatment of cancer. In microarray studies in which p53 was reactivated in MCF7 cells, we discovered that Yippee-like-3 (YPEL3), a member of a recently discovered family of putative zinc finger motif coding genes consisting of YPEL1-5, is a p53-regulated gene. YPEL3 expression induced by DNA damage leads to p53 recruitment to a cis-acting DNA response element located near the human YPEL3 promoter. Physiologic induction of YPEL3 results in a substantial decrease in cell viability associated with an increase in cellular senescence. Through the use of RNAi and H-ras induction of cellular senescence, we show that YPEL3 activates cellular senescence downstream of p53. Consistent with its growth suppressive activity, YPEL3 gene expression is repressed in ovarian tumor samples. One mechanism of YPEL3 downregulation in ovarian tumor cell lines seems to be hypermethylation of a CpG island upstream of the YPEL3 promoter. We believe these findings point to YPEL3 being a novel tumor suppressor, which upon induction triggers a permanent growth arrest in human tumor and normal cells.