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Bioorg Med Chem
; 13(4): 1409-13, 2005 Feb 15.
Article
in English
| MEDLINE
| ID: mdl-15670949
ABSTRACT
The antibiotic cytosporone E (isolated from the broth of the endophytic fungi CR 200 (Cytospora sp.) and CR 146 (Diaporthe sp.)) was synthesized as a racemic mixture. The key step in the synthesis is the Meyers ortho-alkylation of a chiral aromatic oxazoline. Preliminary antibiotic activity shows antibiosis against Gram-positive bacteria but not Gram-negative bacteria as previously reported.