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Ultrasound Med Biol ; 47(12): 3480-3490, 2021 12.
Article in English | MEDLINE | ID: mdl-34507874

ABSTRACT

A change in elastin and collagen content is indicative of damage caused by hypertension, which changes the non-linear behavior of the vessel wall. This study was aimed at investigating the feasibility of monitoring the non-linear material behavior in an angiotensin II hypertensive mice model. Aortas from 13 hypertensive mice were imaged with pulse wave imaging (PWI) over 4 wk using a 40-MHz linear array. The pulse wave velocity was estimated using two wave features: (i) the maximum axial acceleration of the foot (PWVdia) and (ii) the maximum axial acceleration of the dicrotic notch (PWVend-sys). The Bramwell-Hill equation was used to derive the compliance at diastolic and end-systolic pressure. This study determined the potential of PWI in a hypertensive mouse model to image and quantify the non-linear material behavior in vivo. End-systolic compliance could differentiate between the sham and angiotensin II groups, whereas diastolic compliance could not, indicating that PWI can detect early collagen-dominated remodeling.


Subject(s)
Aorta, Abdominal , Hypertension , Animals , Aorta, Abdominal/diagnostic imaging , Blood Pressure , Feasibility Studies , Mice , Pulse Wave Analysis
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