ABSTRACT
The burden of chronic kidney disease is increasing throughout New Zealand, resulting in growing strain on patients, families and the healthcare system. The population of South Auckland is the most diverse in New Zealand and it is particularly vulnerable to the effects of chronic kidney disease due its demography and its many communities that endure significant hardships. This article explores the prevailing challenges identified by renal physicians and nurse specialists over 35 years of caring for patients with chronic kidney disease in South Auckland.
Subject(s)
Renal Insufficiency, Chronic , Humans , New Zealand , Renal Insufficiency, Chronic/therapyABSTRACT
On 22 February 2011, a large earthquake struck the Canterbury region in New Zealand. There was extensive damage to buildings and infrastructure. The following day 42 haemodialysis patients were flown to Auckland where they acutely dialysed through the efforts of the Auckland, Waitemata and Counties-Manukau dialysis team. Patients and support people were subsequently distributed to a designated Upper North Island District Health Board for longer-term ongoing dialysis care. The last evacuated haemodialysis patient returned to Christchurch on 9 May 2011. Surprisingly there was a dearth of crush syndrome patients requiring dialysis. The evacuation and reception of a large number of dialysis patients was a novel experience for the New Zealand dialysis community. A planning guide for dialysis emergency is available to assist with similar future natural disasters.
Subject(s)
Delivery of Health Care/organization & administration , Disaster Planning/organization & administration , Earthquakes , Emergency Medical Services/organization & administration , Relief Work/organization & administration , Renal Dialysis , Air Ambulances/organization & administration , Crush Syndrome/epidemiology , Crush Syndrome/therapy , Humans , New Zealand/epidemiology , Organizational Objectives , Patient Transfer/organization & administration , Time FactorsSubject(s)
Hydronephrosis/congenital , Multicystic Dysplastic Kidney/diagnosis , Obesity, Morbid/complications , Ureteral Obstruction/diagnosis , Adult , Humans , Hydronephrosis/complications , Hydronephrosis/diagnosis , Male , Multicystic Dysplastic Kidney/complications , Ureteral Obstruction/complicationsABSTRACT
BACKGROUND: Recent data have suggested that glomerular filtration rate (GFR) is better predicted in New Zealand (NZ) Maori and Pacific People using the equations for Black people that predict higher GFR for any given serum creatinine. We hypothesized that this might be due to a higher rate of creatinine generation in NZ Maori and Pacific People. AIM: To compare creatinine kinetics between different ethnic groups in a cohort of NZ peritoneal dialysis patients. METHODS: In this retrospective single-centre observational study, creatinine kinetics in 181 patients were determined from timed serum samples, peritoneal dialysate and urine collections between 1 October 2004 and 31 July 2011. Ethnicity was classified as Asian, NZ European, NZ Maori and Pacific People. RESULTS: A total of 799 samples from 181 patients were analysed: 194 in Asians, 127 in NZ Europeans, 268 in NZ Maori, 207 in Pacific People. Pacific People had the highest serum creatinine and lean body mass, and the highest creatinine generation rate at 1349 mg/day, compared with 1049 for Asians, 1186 for NZ Europeans and 1094 for NZ Maori (P = 0.0001). After adjustment for confounding factors, Pacific People had a greater creatinine generation by 140 mg/day compared with NZ Europeans (P = 0.047). CONCLUSION: Pacific People on peritoneal dialysis in NZ have higher serum creatinine, lean body mass and creatinine generation than other ethnic groups. This is consistent with previous observations that equations for predicting GFR in Black people may have increased accuracy in some Australasian non-White non-Asian populations.
Subject(s)
Creatinine/blood , Glomerular Filtration Rate , Kidney Failure, Chronic/diagnosis , Kidney Failure, Chronic/ethnology , Native Hawaiian or Other Pacific Islander/statistics & numerical data , Aged , Asian People/statistics & numerical data , Biomarkers/blood , Body Mass Index , Body Weight/ethnology , Female , Humans , Kidney Failure, Chronic/blood , Kidney Failure, Chronic/therapy , Kinetics , Male , Middle Aged , Models, Biological , New Zealand/epidemiology , Peritoneal Dialysis , Predictive Value of Tests , Retrospective Studies , White People/statistics & numerical dataSubject(s)
Esophageal Achalasia/etiology , Intestinal Obstruction/etiology , Peritoneal Dialysis, Continuous Ambulatory/adverse effects , Peritoneal Fibrosis/etiology , Abdominal Pain/etiology , Adult , Chest Pain/etiology , Esophageal Achalasia/diagnostic imaging , Esophageal Achalasia/therapy , Female , Humans , Intestinal Obstruction/diagnosis , Intestinal Obstruction/therapy , Peritoneal Fibrosis/diagnosis , Peritoneal Fibrosis/therapy , Tomography, X-Ray Computed , Vomiting/etiologyABSTRACT
BACKGROUND: Accurate estimation of glomerular filtration rate (GFR) allows early detection of renal disease and maximizes opportunity for intervention. AIM: To assess the accuracy of estimated GFR (eGFR) in an Australian and New Zealand cohort with chronic kidney disease using the 4-variable Modification of Diet in Renal Disease equation (MDRD(4V)), the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations, and the Cockcroft and Gault equation with actual and ideal body weight. METHODS: Retrospective review of patients who had measured GFR (mGFR) by 51Cr-EDTA clearance and simultaneous measurements of serum biochemistry and anthropometrics. eGFR was compared with mGFR using the concordance correlation coefficient (CCC) and Bland-Altman measures of agreement. RESULTS: 178 patients had 441 radioisotope measurements of GFR. Mean mGFR of was 22.6 mL/min per 1.73 m(2) . The MDRD(4V) equation using the 'black' correction factor was most accurate with a mean eGFR of 19.74 (CCC 0.733, bias -2.86). The CKD-EPI equations also using the 'black' correction factors were almost as good at 19.11 (CCC 0.719, bias -3.49). The Cockcroft-Gault creatinine clearance values had the poorest agreement with mGFR. In the 18 nonwhite non-Asian patients, the MDRD(4V) and CKD-EPI equations were generally less accurate although the use of the 'black' correction factor resulted in greater accuracy for both equations. CONCLUSION: The MDRD(4V) equation was the most accurate. However, its accuracy might be less for nonwhite non-Asian patients if the 'black' correction factor is omitted. Further study of the estimation of GFR in Australian and New Zealand ethnic subgroups would be helpful.
Subject(s)
Glomerular Filtration Rate , Adult , Aged , Australia , Cohort Studies , Female , Humans , Male , Middle Aged , New Zealand , Retrospective StudiesABSTRACT
AIM: Nephrogenic systemic fibrosis (NSF) is a rare and serious disease characterised by thickening and hardening of the skin with fibrosis of the dermis with CD34-positive fibrocytes. NSF occurs in patients with renal failure and has been linked to exposure of gadolinium contrast agents. The Auckland region has a population of 1.3 million with consultation and dialysis services for patients with end stage kidney disease provided by two separate renal units. The aim of this study was to determine the incidence and frequency of NSF in the Auckland region and determine the risk based on exposure to gadolinium based contrast agents. METHODS: A retrospective case notes review of all patients with end stage kidney disease under the care of the renal services between 1(st) January 2000 and 31(st) December 2006 was undertaken. All cases of proven or suspected NSF were identified. Using a picture archive and communications support system all imaging and exposure to contrast was identified. RESULTS: Three cases of biopsy proven NSF and two further cases of clinical NSF were identified. In all cases there was exposure to Gadolinium. This risk of NSF on exposure to any gadolinium based contrast agents was 0.67%. Gadodiamide was used in one institution where all five cases of NSF were seen, gadodiamide was used in 1% of patients in the other institution with no recognised cases. CONCLUSION: The incidence of NSF is low with the greatest risk on exposure to linear, non-ionic chelates, with no ethnic predisposition.
