Long-term sequelae of autologous bone marrow or peripheral stem cell transplantation for lymphoid malignancies.

The study was made to evaluate the long-term physical and psychosocial changes after high-dose therapy and autologous bone marrow or peripheral stem transplantation for recurrent lymphoid malignancies. Patients who had undergone high dose therapy and autologous bone marrow or peripheral stem cell transplantation for recurrent lymphoid malignancies at least 1 year previously were contacted by phone interview regarding their status after the transplant. The patients' comments were confirmed by checking medical records when possible. Fifty patients who had undergone transplantation at the University of Nebraska Medical Center at least 1 year before the interview were available for interview and willing to answer questions. After transplant, many patients noticed temporary changes in their appearance, which usually returned to normal within 1 year. Few patients reported remarkable cardiovascular, gastrointestinal, or pulmonary changes after transplantation. However, up to one-third of the patients reported changes in sexual function or desire. The most common infectious problem after transplant was Herpes zoster, which occurred in 25% of the patients. Overall, the patients had a positive outlook after high-dose therapy and transplantation, with most being able to return to work and enjoy a normal life style. Ninety-six percent of the patients stated that they would be willing to undergo high-dose therapy and transplantation again under the same circumstances.

Image plane detector for the Dynamics Explorer Fabry-Perot interferometer.

A compact twelve-channel photon-counting device based on existing Generation II imaging technology has been developed for use as the image-plane detector of the Dynamics Explorer Fabry-Perot interferometer. The device has an S-20 photocathode, three-microchannel plate electron multiplication stages, and an equal-area concentric-ring segmented anode whose geometry mimics that of the interference ring pattern produced by a plane etalon. The twelve channels sample equal and contiguous intervals in the spectrum. The purpose of the development has been to utilize the signal multiplex advantage of a multichannel detector in the measurement of Doppler shifts and line-broadening effects for naturally occurring atmospheric emission features of low intensity. The design, testing, calibration, and flight performance of the novel detector system are presented. In addition, measured emission line profiles at high resolution from the satellite instrument are presented to illustrate the operation of the device.

Stable and rugged etalon for the Dynamics Explorer Fabry-Perot interferometer. 2: Performance.

This is the second of two papers which describe the development and performance of the Fabry-Perot etalon flown on the Dynamics Explorer spacecraft. The Dynamics Explorer instrument is designed to measure winds in the upper atmosphere by observing the Doppler shift of various emission features. The etalon remains stable to <5-m/sec equivalent wind over one orbit and <100 m/sec over several months in orbit. This paper discusses the thermal stability considerations for the highly stable etalon including the passive thermal control used in flight and presents a new kinematic etalon mount design which eliminates undesirable thermomechanical coupling between the etalon and its mount. A series of thermal vacuum tests has identified the major causes of thermally induced drift in the etalon transmission. The performance of the flight etalon is discussed.