ABSTRACT
Only 7 cases of human poisoning with amitraz have been previously published and most of them are poorly documented. Four additional cases are now reported. The symptoms observed were remarkably similar in all cases: all patients experienced drowsiness; 3 presented with bradycardia, miosis and/or hyperglycemia; 2 developed hypotension and/or vomiting. These symptoms are compared to those observed in previous human or animal poisoning. Alpha 2-adrenoceptor stimulation could explain the clinical and laboratory features in most cases.
Subject(s)
Insecticides/poisoning , Receptors, Adrenergic, alpha-2/drug effects , Toluidines/poisoning , Adult , Aged , Aged, 80 and over , Bradycardia/chemically induced , Female , Humans , Hyperglycemia/chemically induced , Hypotension/chemically induced , Infant , Male , Miosis/chemically induced , Sleep Stages , Vomiting/chemically inducedABSTRACT
The absorption of vitamin B12, labelled with radioactive 58Co, was measured in 19 patients with cystic fibrosis and one child with the Shwachman-Diamond syndrome using the whole body counting technique. We found vitamin B12 absorption reduced to 7.97 on average, compared to 59.2% for the control group. The low vitamin B12 absorption correlated well with the reduced fat retention coefficients. After adding 0.212 pancreatin to the radioactive vitamin B12 test dose, the absorption quotas improved in all cases, the average being 61%. A meal poor in vitamin B12 tended to increase the absorption of the radioactive test dose to 23% on average. As yet there is no satisfactory explanation for the effect of the diet on the absorption of vitamin B12 in exocrine pancreatic insufficiency. This could be the reason why the malabsorption of vitamin B12 in patients with EPI can go unnoticed for many years and could possibly explain why vitamin B12 malabsorption in exocrine pancreatic insufficiency does not cause symptoms and signs of vitamin B12 deficiency for many years.
