Comparisons between African American girls' and parents' perceptions of girls' weight concerns and weight control behaviors.

Weight concerns and weight control behaviors were evaluated among sixty 8-10 year-old African American girls and their parents/caregivers. Girls completed the McKnight Risk Factor Survey and parents completed a modified version regarding perceptions of their daughters' concerns and behaviors. Significant correlations between girls' and parents' were seen for Overconcern with Weight and Shape (r = .56) and Weight Control Behaviors (r = .33). Parents' correctly identified 72% of girls' responses for Overconcern with Weight and Shape, 60% for Binge, 85% for Purging and 58% for Weight Control Behaviors scales using clinical cutoffs. However, more stringent agreement coefficients indicated generally poor concordance between girls and parents. The modified McKnight may be useful for assessing awareness of these issues.

Dexamethasone suppresses peripheral prostanoid levels without analgesia in a clinical model of acute inflammation.

PURPOSE: The therapeutic effects of glucocorticoids are generally attributed to suppression of multiple signaling pathways involved in the inflammatory response leading to decreased levels of inflammatory mediators at the site of injury. This study evaluated the in vivo relationship between levels of prostanoids at the site of tissue injury and analgesia after dexamethasone administration in a clinical model of tissue injury. METHODS: Subjects were administered dexamethasone 4 mg or placebo 12 hours and 1 hour before the removal of 2 mandibular third molars. A microdialysis probe was implanted at each surgical site for measurement of immunoreactive prostaglandin E2 (PGE(2)) or immunoreactive thromboxane B(2) (TxB(2)), and pain was measured concurrently. Subjects received either ketorolac 30 mg intravenously or placebo at pain onset. RESULTS: PGE(2) was detectable in the first postoperative sample, decreased over the next hour and then increased coincident with the onset of postoperative pain. Administration of dexamethasone suppressed PGE(2) levels in samples collected at pain onset in comparison to placebo and significantly suppressed TxB(2) at the surgical site but without any effect on pain report. Subsequent administration of ketorolac significantly reduced pain while decreasing both PGE(2) and TxB(2) levels at the surgical site. CONCLUSION: The lack of an analgesic effect for dexamethasone while reducing both PGE(2) and TxB(2) at the site of injury in comparison to ketorolac analgesia accompanied by greater reductions in levels of these prostanoids suggests that glucocorticoids at this dose do not suppress PGE(2) release sufficiently to attenuate peripheral sensitization of nociceptors after tissue injury.

Peripheral prostanoid levels and nonsteroidal anti-inflammatory drug analgesia: replicate clinical trials in a tissue injury model.

BACKGROUND: Nonsteroidal anti-inflammatory drug (NSAID) analgesia is generally attributed to peripheral suppression of cyclooxygenase (COX) enzymes, leading to decreased products of the arachidonic acid cascade. This study evaluated the in vivo relationship between levels of prostanoids at the site of tissue injury and analgesia after systemic or local NSAID administration in a clinical model of tissue injury. METHODS: Subjects in two replicate clinical trials had one or two mandibular third molars removed and a microdialysis probe implanted at the surgical site for measurement of immunoreactive prostaglandin E(2) (PGE(2)) or immunoreactive thromboxane B(2) (TxB(2)) and pain measured concurrently. In the first study, ketorolac tromethamine (INN, ketorolac) was administered at pain onset in a 30-mg intramuscular dose, a 1-mg intramuscular dose, or a 1-mg submucosal dose at the extraction site in comparison with placebo. In the second study, subjects received either ketorolac tromethamine 30 mg by the intravenous route or placebo at pain onset. RESULTS: PGE(2) was detectable in the first postoperative sample, decreased over the next hour, and then increased significantly coincident with the onset of postoperative pain. Administration of 30 mg ketorolac tromethamine produced parallel decreases in pain, PGE(2) levels, and TxB(2) levels at the surgical site. Administration of 1 mg ketorolac tromethamine intramuscularly or directly at the surgical site was analgesic but without measurable effects on PGE(2) levels. CONCLUSION: The temporal profile of PGE(2) and TxB(2) in the immediate postoperative period is consistent with constitutive COX-1 initially, followed by an increase in PGE(2) resulting from expression of COX-2. The temporal association between NSAID analgesia and decreased prostanoids at the site of injury is consistent with a dual COX-1/COX-2 peripheral site of action. The analgesic effects of 1 mg ketorolac tromethamine without a reduction in PGE(2) at the site of injury suggests an additional central site for NSAID analgesia.

Estudio cualitativo con trabajadoras sexuales comerciales en La Paz y El Alto sobre el uso de condones femeninos y masculinos

PROSALUD y PSI Trabajan conjuntamente el Ministerio de Salud, con el Programa de VIH-SIDA y con los Centros de Salud donde van a su control medico las trabajadoras sexuales comerciales. En estos lugares, habian comentarios de que un mismo condon femenino "Reality" habia sido utilizado por las trabajadoras sexuales por mas de una relacion sexual, ademas indicando que el condon masculino "Pantera" se rompe algunas veces. Para indicar dicha información emitida se decidio realizar un estudio cualitativo del uso de condones masculino y femenino por las trabajadoras sexuales comerciales en la ciudad de La Paz y El Alto para saber sus conocimientos, actitudes y practicas sobre condones masculinos y femeninos