ABSTRACT
It is a well-known fact among clinicians that sunlight may exacerbate atopic dermatitis (AD), but little is known beyond that. In a preliminary study investigating this phenomenon, 19 patients with AD were selected for phototests. All of them had a normal minimal erythema dose (MED). However, 3 patients (15.7%) demonstrated abnormal cutaneous responses 24-72 h after provocation with ultraviolet light B (UVB). None of the patients had a positive response to pure ultraviolet light A (UVA) irradiation of up to 9 J/cm2. The photobiological results of this study confirm the existence of photosensitivity in AD and indicate that UVB wavelengths are responsible for it.
Subject(s)
Dermatitis, Atopic/complications , Photosensitivity Disorders/etiology , Ultraviolet Rays/adverse effects , Adolescent , Adult , Child , Dermatitis, Atopic/pathology , Dose-Response Relationship, Radiation , Female , Humans , Photosensitivity Disorders/pathology , Skin TestsABSTRACT
We report 5 cases of photocontact dermatitis due to suprofen, a nonsteroidal anti-inflammatory drug introduced to the Japanese market in 1989, and available as a 1% ointment. The patients developed pruritic eczematous lesions after applying the ointment for from 2 weeks to 3 months. All 5 patients reacted positively to photopatch testing with ultraviolet A (UVA) and suprofen down to 0.1-0.01% pet., and 3 patients showed positive reactions with ultraviolet B (UVB) and suprofen down to 1.0-0.1%. Moreover, all patients showed a cross-reaction with tiaprofenic acid, which has a very similar chemical structure to suprofen. However, there was no cross-reaction between suprofen and ketoprofen. Prescribers should be aware of the existence of photocontact sensitivity due to these drugs.
Subject(s)
Dermatitis, Contact/etiology , Drug Eruptions/etiology , Photosensitivity Disorders/chemically induced , Suprofen/adverse effects , Adolescent , Adult , Aged , Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Anti-Inflammatory Agents, Non-Steroidal/chemistry , Cross Reactions , Facial Dermatoses/chemically induced , Female , Humans , Male , Middle Aged , Patch Tests , Propionates/adverse effects , Propionates/chemistry , Suprofen/chemistryABSTRACT
The interaction of ultraviolet A (UVA) and UVB in producing delayed pigmentation was quantitatively studied on the backs of 19 healthy Japanese subjects. The minimal pigementation dose for UVA (MPDA) and UVB (MPDB) was first determined using narrow-band radiation of 360 nm and 290 nm respectively. The average MPDA and MPDB was 16.4 J/cm2 and 32.9 mJ/cm2 respectively. In experiment 1, fractional doses of 0.2, 0.4, 0.6 and 0.8 MPDA were first irradiated on 4 sites each. Immediately following each exposure, fractional doses of either 0.2, 0.4, 0.6 or 0.8 MPDB were superimposed on the same sites, resulting in each exposure site receiving a different combination of fractions of MPDA and MPDB (A + B). This was repeated with the sequence of exposure reversed (B + A). The results demonstrated that the wavelengths interacted via photoaddition in producing delayed pigmentation, irrespective of the order of exposure. When a 3-h time interval was allowed between exposures in experiment 2, there was again no evidence of deviation from photoaddition with either order of exposure. This study shows that subthreshold doses of UVA and UVB interact additively in the production of delayed pigmentation.
Subject(s)
Skin Pigmentation/radiation effects , Ultraviolet Rays , Adolescent , Adult , Dose-Response Relationship, Radiation , Female , Humans , Male , Time FactorsABSTRACT
Two cases of infundibular keratosis are presented, characterized histopathologically by funnel-shaped, invaginating, epithelial lobules showing infundibular keratinization and connection with pilosebaceous structures. Lightly-staining, glycogen-laden epithelial cells predominated within the two tumors. Differential diagnoses with other infundibular tumors and relationships to trichilemmoma are discussed.
Subject(s)
Facial Dermatoses/pathology , Keratosis/pathology , Aged , Aged, 80 and over , Humans , Male , Skin Neoplasms/pathologyABSTRACT
A 4-year-old boy was seen at the Kanto Teishin Hospital because of a lesion present at birth. Examination revealed a round, soft, soybean-sized, pedunculated nodule on the midline anterior neck region. Histologically, the most conspicuous aberration was the presence of bundles of striated skeletal muscle fibers throughout the dermis. This nodule was diagnosed as rhabdomyomatous mesenchymal hamartoma of skin, a name first given by Mills. We believe this is the first report of this condition in Japan.
Subject(s)
Hamartoma/pathology , Skin Neoplasms/pathology , Child, Preschool , Chin , Humans , Male , Muscles/pathologyABSTRACT
Eight patients suffering from papulovesicular light eruption (PVLE) were phototested for reproduction of skin lesions with FL20SE and FL20BLB. Of the 8 patients, 50.0% developed typical lesions of PVLE at the test site by provocative phototesting with FL20SE (3 daily exposure of 2MED). In these patients, similar lesions were induced by the provocative test with FL20BLB for 2 consecutive days without filter, but no eruptions were induced when a sharp cut filter UV-35 was used. In conclusion, it is important to consider not only UVB but also the border spectrum between UVB and UVA (320-340 nm) as the action spectrum of PVLE.
Subject(s)
Photosensitivity Disorders/diagnosis , Adult , Female , Humans , Middle Aged , Photosensitivity Disorders/pathology , Skin/pathology , Skin/radiation effects , Spectrum Analysis , Ultraviolet Rays/adverse effectsABSTRACT
Sib patients with xeroderma pigmentosum (XP), XP90TO (42 years old, male) and XP92TO (40 years old, female, were assigned to group F by the complementation analysis in hybridized heterodikaryons. The XP90TO and XP92TO fibroblasts exhibited the typical XPF characteristics of a threefold higher sensitivity to the lethal effect of 254 nm UV and a reduced level of 12% unscheduled DNA synthesis (UDS) compared with normal cells. Clinically, both patients manifested moderate to severe acute sun sensitivity by age 8, pigmented freckles by age 10 and skin malignancies at higher ages (6 basaliomas at 42 years in XP90TO; 1 basalioma at 41 years in XP92TO). Despite the still currently sun-sensitive state, the patients showed normal minimal erythema dose (MED) at monochromatic wavelengths of 290, 300 and 305 nm but abnormally delayed peaking of erythema reaction at 48 h after exposure. After irradiation with more than 3 MED, XP92TO showed a long persistence of induced erythema for at least 7 days. A review of the 16 reported XPF patients indicated mild skin manifestations, no neurological abnormalities, and more delayed skin carcinogenesis at a lower frequency than that in XPA patients. In addition, we have collected clinical information from Japanese XP patients in rare complementation groups D and E and reviewed their clinical and photobiological characteristics.
