Subject(s)
Adolescent Behavior , Body Image , Dermatology , Physician's Role , Smoking Cessation , Smoking/adverse effects , Adolescent , Beauty , Dermatology/methods , Female , HumansABSTRACT
Perforating disorders in patients with chronic renal failure (CRF), diabetes mellitus (DM), or both, may resemble any or all of the four classic cutaneous perforating disorders. However, due to the highly variable and overlapping histologic appearance of the lesions in patients with CRF, DM, or both, it may be useful to categorized these lesions as a distinct, yet encompassing process, termed by Rapini as acquired perforating dermatosis. We describe a patient with both CRF and DM with acquired perforating dermatosis.
Subject(s)
Diabetes Complications , Hand Dermatoses/diagnosis , Hand Dermatoses/etiology , Kidney Failure, Chronic/complications , Diagnosis, Differential , Female , Hand Dermatoses/pathology , Humans , Middle AgedABSTRACT
Hypoprothrombinemic states are commonly treated with injectable vitamin K. Cutaneous vitamin K hypersensitivity can manifest as eczematous or sclerodermoid lesions and historically has been related to the use of fat-soluble vitamin K1. We present a case of warfarin-induced hypoprothrombinemia treated with aqueous vitamin K1, which resulted in the appearance of eczematous vitamin K1 hypersensitivity.
Subject(s)
Eczema/chemically induced , Vitamin K/adverse effects , Adult , Eczema/pathology , Female , Humans , Hypoprothrombinemias/drug therapy , Injections, Subcutaneous , Vitamin K/therapeutic useABSTRACT
Although drug eruptions caused by pravastatin and other lovastatin analogs have previously been described, reports of lichenoid eruptions are rare. We report a patient whose lichenoid lesions developed after initiation, resolved on discontinuation, and reappeared on rechallenge with pravastatin therapy. A brief review of lichenoid drug eruptions and skin lesions due to 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors is discussed.
Subject(s)
Anticholesteremic Agents/adverse effects , Hydroxymethylglutaryl-CoA Reductase Inhibitors/adverse effects , Lichenoid Eruptions/chemically induced , Pravastatin/adverse effects , Aged , Diagnosis, Differential , Humans , Lichenoid Eruptions/pathology , MaleABSTRACT
Rheumatoid neutrophilic dermatitis (RND) is a rare cutaneous finding in patients with severe rheumatoid arthritis or with high-titer rheumatoid factors. Most commonly, these lesions are erythematous papules or plaques distributed symmetrically on extensor surfaces. On histologic examination a dense dermal neutrophilic infiltrate without vasculitis is apparent. The pathogenesis of RND is unclear, and few treatments are known. With careful clinical and histologic examination, RND may be differentiated from the wide array of other cutaneous findings in rheumatoid arthritis.
Subject(s)
Arthritis, Rheumatoid/complications , Dermatitis/pathology , Neutrophils/pathology , Skin/pathology , Dermatitis/complications , Female , Humans , Middle AgedABSTRACT
A wide range of infectious, neoplastic, and inflammatory dermatoses can affect the glans penis or prepuce. Some are unique to the genitalia. Other more common dermatoses may have a unique appearance when they involve genital skin and mucosa. A thorough understanding of regional anatomy and a systematic diagnostic approach are helpful in the management of a refractory penile dermatosis. We review embryology and regional anatomy, drug-induced eruptions, allergic and irritant dermatitis, infection, neoplasia, and traumatic and inflammatory dermatoses as they relate to the glans and prepuce. Our discussion focuses on the clinical features, office laboratory studies, and histopathologic findings that assist in diagnosis and treatment.
