Decreased medial entorhinal cortical thickness in olanzapine exposed female rats is not ameliorated by exercise.

Aerobic exercise has been associated with hippocampal plasticity, both in healthy adults and in psychosis patients, but its impact on cortical regions remains unclear. The entorhinal cortex serves as a critical gateway for the hippocampus, and recent studies suggest that this region may also be impacted following an exercise regime. In order to investigate the effects of antipsychotic medications and exercise on the entorhinal cortex, female rats were chronically administered either olanzapine or vehicle and were either sedentary or had access to a running wheel for 9 weeks. Olanzapine-treated rats had decreased medial entorhinal cortical thickness compared to vehicle-treated rats. A statistically significant interaction was observed for layer II of the entorhinal cortex, with exercising rats having significantly greater thickness compared to sedentary rats in the vehicle group, but not the olanzapine group. Greater total entorhinal and lateral entorhinal cortical thickness was associated with greater average activity. In exercising rats, decreasing glucose intolerance was associated with larger total entorhinal and layer II cortical thickness. Lower fasting insulin levels were associated with greater total entorhinal, lateral entorhinal, and layer II cortical thickness. The relationship between increased activity and greater entorhinal cortical thickness was mediated by reduced fasting insulin, indicating that regulation of metabolic risk factors may contribute to impact of aerobic exercise on the entorhinal cortex. Aerobic exercise may be helpful in counteracting metabolic side effects of antipsychotic medications and managing these side effects may be key to promoting entorhinal cortical plasticity in patients treated with second-generation antipsychotic drugs.

Return to work and sports after total hip replacement.

INTRODUCTION: Expectations of patients requiring total hip replacement have become higher than in the past and are often well beyond pain relief and improved mobility. Return to work and sporting activity are important factors to be considered when advising patients preoperatively. The objective of this study was to analyse the return to sports and work rates in patients still in employment and to analyse potential influencing factors. MATERIALS AND METHODS: Patients under the age of 65 who had a total hip replacement performed at a university teaching hospital were identified from the local arthroplasty database and contacted. Pre and postoperative levels of sporting activity and work were recorded. We also recorded the time point at which they returned to these activities. RESULTS: 285 total hip replacements were carried out on 239 patients. At the time of follow-up 170 of the patients were working. The mean length of time to return to work was 13.9 weeks (SD 7.7). 78 % returned to work without any restrictions, 18.6 % in heavy manual jobs. The mean time taken to return to sports or similar physical activities was 18.8 weeks (SD 8.8) weeks. Those with a lower body mass index returned to work and sporting activities faster. CONCLUSIONS: Our data show that the majority of patients undergoing total hip replacement can expect to return to work and sporting activities within 4-6 months. Activities at work are often initially limited and physical performance may not fully return to the expected level. Patients with a high body mass index take longer to return to work and sporting activities.

The association between submission counts to a veterinary diagnostic laboratory and the economic and disease challenges of the Ontario swine industry from 1998 to 2009.

An intuitive assumption is to believe that the number of submissions made to a veterinary diagnostic laboratory is dictated by the financial state of the industries using the laboratory. However, no research is available to document how the economics of a food animal industry affects laboratory submissions and therefore disease monitoring and surveillance efforts. The objective of this study was to determine if economic indices associated with the Ontario swine industry can account for the variability seen in these submissions. Retrospective swine submissions made to the Animal Health Laboratory at the University of Guelph, Guelph, Ontario from January 1998 to July 2009 were compiled. The following economic, demographic, and health variables impacting Ontario swine production were selected for analysis: auction price, lean-hog futures, currency exchange rate, price of corn, an outbreak of porcine circovirus type-2 associated diseases (PCVAD), government incentive program, number of farms in province, and average farm size. All independent variables identified by unconditional associations to have a significance of P≤0.2 with the outcome of monthly submission count were included in a multivariable negative binomial model. A final model was identified by a backwards elimination procedure. A total of 30,432 swine submissions were recorded. The mean frequency of monthly submissions over 139 months was 212.9 (SD=56.0). After controlling for farm size, the number of pigs in Ontario, higher submission counts were associated with a weaker CAD$ versus US$, higher auction prices, and a PCVAD outbreak (P<0.001). The results suggest that both economic volatility and disease outbreaks in the Ontario swine industry drive submissions to the laboratory. In conclusion, lab submissions are a useful source of animal health data for disease surveillance; however, surveillance activities should also monitor the economics of the industry.

Esthetics and smile characteristics from the layperson's perspective: a computer-based survey study.

BACKGROUND: The paradigm shift from occlusion to esthetics places more emphasis on the subtle relationships among the teeth and the interplay with the soft tissues. The authors of this study quantified the ideal and maximum acceptable deviations for smile characteristics. METHODS: The authors created a survey by using a digital image editing software package, which enabled raters to manipulate intraoral photographs featured in the survey. They altered smile characteristics in photos of a sex-neutral face showing nasal tip to mentolabial fold. The authors administered an electronic survey in Boston (n = 78); Columbus, Ohio (n = 81); and Seattle (n = 84). An interactive interface allowed raters to select the ideal for each smile characteristic presented and identify the range of acceptability for the variables. RESULTS: Raters were reliable (kappa = 0.34-0.88). Survey location was not significant except that raters from the West accepted a broader smile than did those from the Midwest and the East. Raters identified ideals and thresholds for the following smile characteristics: smile arc; buccal corridor; gingival display; canine and posterior crown torque, ideal and large corridor; maxillary midline to face; maxillary to mandibular midline; overbite; maxillary central incisor gingival height discrepancy; maxillary lateral incisor gingival height discrepancy; maxillary central to lateral incisal step; maxillary central incisor crown width-to-height ratio; maxillary central-to-lateral incisal ratio; and occlusal cant. Generally, the values for ideal paralleled existing data, and new guidelines for some variables emerged. The ranges of acceptability were large. CONCLUSIONS: The ideal and an acceptable range for each smile characteristic can be identified reliably. PRACTICE IMPLICATIONS: Laypeople can reliably identify ideal smile characteristics. The ranges of acceptable deviations for smile characteristics are large, and practitioners should avoid unnecessarily sensitizing patients to minor discrepancies.

Making faces: creating three-dimensional parameterized models of facial expression.

Previous studies of the perceptual processing and dynamics of emotional expression in faces have been limited by the lack of realistic yet controlled stimuli. The present work offers researchers a method for creating such stimuli for exploring these phenomena. We describe the creation of the stimuli and a series of experiments testing the validity of these stimuli with respect to emotional expressions in humans. Participants evaluated synthesized facial images and standardized photographs of six basic emotional expressions for intensity and accuracy of perceived emotion. Comparisons of these measures were qualitatively similar for synthesized and photographed faces. A manipulation of the magnitude of the synthesized expressions yielded a significant effect on the perceived intensity of expression. In a subsequent multidimensional scaling study, no systematic differences were uncovered in the derived configurations of the synthesized expressions and the photographs. These results are discussed in the context of possible future research applications.

Structural principles and amorphouslike thermal conductivity of Na-doped Si clathrates

The postulated low thermal conductivity and the possibility of altering the electronic conductivity of metal-doped clathrates with semiconducting host elements have stimulated great interest in exploring these compounds as promising thermoelectric materials. The electronic and thermal properties of the prototypical Na xSi (46) system are studied in detail here. It is shown that, despite the fact that the Na/Si clathrate is metallic, its thermal conductivity resembles that of an amorphous solid. A theoretical model is developed to rationalize the structural stability of the peculiar structural topology, and a general scheme for rational design of high efficiency thermoelectric materials is presented.

Maize yields hope. Reports from the field -- Africa.

PIP: In Burundi, researchers supported by IDRC have developed several high-yield varieties of maize that are resistant to the streak virus. Although previously more prevalent at low altitudes, the virus, which is carried by a leafhopper (Cicadulina spp.), has increased its affects at higher altitudes. A maize improvement program was established in 1978, with IDRC help, by ISABU, the national agricultural research institute of Burundi; however, the local and foreign maize varieties that were tested were poorly adapted to local conditions and succumbed to the streak virus. Also, farmers preferred a crop that would be ready to harvest in 4-5 because two crops a year would be possible. In 1985, Dr. Dunstan Malithano, a Malawian researcher who had previously worked for IDRC in Mozambique, joined the team. He changed the emphasis to improving local maize populations; superior varieties were being distributed within two years. By 1989, three high-yield varieties resistant to streak disease had been developed; Mugamba 1 and Isega 1 were appropriate for the high and medium altitude areas, and Imbo 1 was appropriate for the lake shores and Imbo plains. Imbo 1 could also be used for making beer, and Dr. Malithano negotiated with the brewery to multiply his improved varieties. Enough seed was produced by the brewery in one year for a limited number of farmers who, in turn, produced 43 tons of seed. This was sold to farmers throughout the Rift Valley who sold their crop back to the brewery. By 1994, 80% of all Burundi maize growers were using these varieties successfully. Kenyan farmers are now interested, and Burundi researchers have been trained to take over the breeding program completely.^ieng

[Hyperimmune antistaphylococcal plasma in the treatment of psoriasis patients]. / Giperimmunnaia antistafilokokkovaia plazma v lechenii bol'nykh posriazom.

The immune status parameters were examined in 132 patients with various dissemination, activity, and length of the process, in whom treatment with hyperimmune antistaphylococcal plasma brought different clinical effect.