Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 3 de 3
Filter
Add more filters










Database
Language
Publication year range
1.
J Perinatol ; 28(3): 230-2, 2008 Mar.
Article in English | MEDLINE | ID: mdl-18309317

ABSTRACT

Maternal antibody-mediated fetal red blood cell destruction secondary to non-D Rhesus (Rh) antibodies is a significant cause of hemolytic disease of the newborn (HDN). Here, we report a rare case of severe HDN associated with maternal antibody to Rh e. In addition to severe anemia, the infant developed thrombocytopenia, conjugated hyperbilirubinemia and cholelithiasis. Resolution of the infant's cholelithiasis occurred following treatment with ursodeoxycholic acid.


Subject(s)
Coombs Test , Erythroblastosis, Fetal/immunology , Rh Isoimmunization/physiopathology , Rh-Hr Blood-Group System/immunology , Cholagogues and Choleretics/therapeutic use , Cholelithiasis/etiology , Erythroblastosis, Fetal/drug therapy , Erythroblastosis, Fetal/physiopathology , Erythrocyte Transfusion , Female , Humans , Hyperbilirubinemia, Neonatal , Infant, Newborn , Phototherapy , Rh Isoimmunization/immunology , Thrombocytopenia/etiology , Ursodeoxycholic Acid/therapeutic use
2.
J Perinatol ; 28(5): 330-4, 2008 May.
Article in English | MEDLINE | ID: mdl-18305487

ABSTRACT

OBJECTIVE: Long-distance air transport (LDAT) of infants with pneumoperitoneum for pediatric surgical evaluation has not been previously reported. We examined whether extremely low birth weight (ELBW) infants with and without pneumoperitoneum would tolerate transport differently. STUDY DESIGN: A retrospective cohort study was conducted comparing ELBW infants diagnosed with pneumoperitoneum to other ELBW infants transported>2000 miles by a trained team from a US Department of Defense tertiary care neonatal intensive care unit in Okinawa, Japan. RESULT: Between 2000 and 2006, 49 air transports met study criteria. Seven of the 49 (14%) infants had pneumoperitoneum at time of transport. The average distance flown was 5346 miles per transport. The 49 infants had a median gestational age of 25 weeks and birth weight of 761+/-127 g. ELBW infants without pneumoperitoneum were transported at a median 58 days of life (DOL; range 30 to 91 days) compared to infants with pneumoperitoneum, who were transported at a median 8 DOL (range 6 to 14 days). At the time of LDAT, infants with pneumoperitoneum were significantly smaller, receiving more arterial and central venous access, more pressors for hypotension, and more mechanical ventilation compared to ELBW infants transported without pneumoperitoneum. In-flight patient-related medical issues were similar regardless of underlying diagnosis or age at the time of transport. CONCLUSION: Successful LDAT of ELBW infants, including critically ill infants with intestinal perforation, is possible. Use of personnel, experienced and trained in aviation transport physiology, overcomes the extreme physiologic operating environment associated with LDATs.


Subject(s)
Air Ambulances , Infant, Extremely Low Birth Weight , Infant, Premature, Diseases/therapy , Pneumoperitoneum/therapy , Age Factors , Female , Humans , Infant , Infant, Newborn , Infant, Premature, Diseases/mortality , Intensive Care, Neonatal/methods , Intestinal Perforation/mortality , Intestinal Perforation/therapy , Japan , Male , Patient Care Team , Pneumoperitoneum/mortality , Survival Rate
3.
Proc Soc Exp Biol Med ; 225(1): 39-48, 2000 Oct.
Article in English | MEDLINE | ID: mdl-10998197

ABSTRACT

The immortalized rat submandibular epithelial cell line, SMG-C6, cultured on porous tissue culture supports, forms polarized, tight-junction epithelia facilitating bioelectric characterization in Ussing chambers. The SMG-C6 epithelia generated transepithelial resistances of 956+/-84Omega.cm2 and potential differences (PD) of -16.9 +/- 1.5mV (apical surface negative) with a basal short-circuit current (Isc) of 23.9 +/- 1.7 microA/cm2 (n = 69). P2 nucleotide receptor agonists, ATP or UTP, applied apically or basolaterally induced a transient increase in Isc, followed by a sustained decreased below baseline value. The peak DeltaIsc increase was partly sensitive to Cl- and K+ channel inhibitors, DPC, glibenclamide, and tetraethylammonium (TEA) and was completely abolished following Ca2+ chelation with BAPTA or bilateral substitution of gluconate for Cl-. The major component of basal Isc was sensitive to apical Na+ replacement or amiloride (half-maximal inhibitory concentration 392 nM). Following pretreatment with amiloride, ATP induced a significantly greater Isc; however, the poststimulatory decline was abolished, suggesting an ATP-induced inhibition of amiloride-sensitive Na+ transport. Consistent with the ion transport properties found in Ussing chambers, SMG-C6 cells express the rat epithelial Na+ channel alpha-subunit (alpha-rENaC). Thus, cultured SMG-C6 cells produce tight polarized epithelia on permeable support with stimulated Cl- secretory conductance and an inward Isc accounted for by amiloride-sensitive Na+ absorption.


Subject(s)
Egtazic Acid/analogs & derivatives , Ion Transport , Submandibular Gland/metabolism , Adenosine Triphosphate/pharmacology , Amiloride/pharmacology , Animals , Calcium/metabolism , Cell Line, Transformed , Chelating Agents/pharmacology , Chlorides/metabolism , Egtazic Acid/pharmacology , Electric Conductivity , Electric Impedance , Epithelial Cells/metabolism , Gluconates/pharmacology , Ion Transport/drug effects , Keratins/analysis , Membrane Potentials , Potassium Channel Blockers , Rats , Sodium/metabolism , Sodium Channels/drug effects , Sodium Channels/physiology , Tight Junctions/physiology
SELECTION OF CITATIONS
SEARCH DETAIL
...