ABSTRACT
Two hundred and ten members belonging to two consecutive generations of 41 atopic families (healthy and affected by clinical atopic manifestations) were investigated for basal immunoglobulin E (IgE) levels and clinical picture. The results show overall increased IgE levels, above standard values in the whole population studied, and a significant correlation between clinical atopy and high IgE levels in the children of the group. Within these families recessive inheritance of abnormally high IgE levels suggests that their high IgE levels are due to a genetically transmitted defect in IgE suppression.
Subject(s)
Hypersensitivity, Immediate/genetics , Immunoglobulin E/analysis , Adolescent , Adult , Age Factors , Child , Child, Preschool , Female , Humans , Hypersensitivity, Immediate/blood , Hypersensitivity, Immediate/epidemiology , Immunoglobulin E/genetics , Israel , Male , Middle Aged , Pedigree , Skin Tests , Social EnvironmentSubject(s)
Hypersensitivity, Immediate/immunology , Immunoglobulins/analysis , Adolescent , Adult , Child , Child, Preschool , Dysgammaglobulinemia/genetics , Female , Humans , Hypergammaglobulinemia/genetics , Hypersensitivity, Immediate/blood , Hypersensitivity, Immediate/genetics , IgA Deficiency , Immunoglobulin E/analysis , Infant , Male , Middle AgedABSTRACT
Investigation of 98 members (healthy and affected) belonging to 17 hay-fever families, for clinical picture, total and specific IgE and HLA A, B, C and DR is presented. There was no significant correlation between hay-fever, total or specific IgE and a certain HLA antigen or haplotype. There was, however, an association between hay-fever and same haplotype within 4 of the 17 families.
