ABSTRACT
Streptomyces No. 4915 was isolated and revealed to produce cinerubins A and B. This strain was different from other cinerubins-producing strains. Production of cinerubins is reported. Assignments of the signals of the 13C-NMR spectrum of cinerubin A, the major product, have been made.
Subject(s)
Anti-Bacterial Agents/biosynthesis , Streptomyces/metabolism , Carbon/metabolism , Culture Media , Fermentation , Streptomyces/classification , Time FactorsABSTRACT
Volatile sulfur compounds production by eight strains of Brevibacterium linens isolated from cheeses was demonstrated: methanethiol, dimethyldisulfide, and 2,3,4-trithiapentane. Four of these strains also produced S-methylthioacetate, an important aroma component of smear-coated cheeses. It is the first demonstrated microbiological production of a thioester.
ABSTRACT
Alborixin is an ionophorous antibiotic of the nigericin group isolated from cultures of a strain of Streptomyces albus. It is active against Gram-postive bacteria and is coccidiostatic, but it is very toxic. The antibacterial principle was extracted with organic solvent from the mycelium, isolated in crystalline form and named alborixin.
Subject(s)
Anti-Bacterial Agents , Ionophores , Animals , Anti-Bacterial Agents/biosynthesis , Anti-Bacterial Agents/isolation & purification , Anti-Bacterial Agents/pharmacology , Bacteria/drug effects , Eimeria/drug effects , Fermentation , Lethal Dose 50 , Mice , Streptomyces/classification , Streptomyces/cytology , Streptomyces/metabolismABSTRACT
Alborixin, a polycyclic polyether ionophorous antibiotic, active against Gram-positive bacteria and fungi, was isolated from cultures of a strain of Streptomyces albus. The isolation, structure and physiochemical properties of this antibiotic are reported. Some derivatives have been prepared and their structures and properties are also described in this paper.
Subject(s)
Anti-Bacterial Agents/analysis , Ionophores/analysis , Acetylation , Anti-Bacterial Agents/biosynthesis , Chemical Phenomena , Chemistry , Crystallization , Fermentation , Models, Chemical , Oxidation-ReductionABSTRACT
Grisorixin is an ionophorous antibiotic of the nigericin group isolated from cultures of a strain of Streptomyces griseus. It shows activity against Gram-positive bacteria and fungi but is also very toxic. The isolation and purification procedures are reported. Its structure and physico-chemical properties are also described.
Subject(s)
Anti-Bacterial Agents , Nigericin , Animals , Bacteria/drug effects , Fermentation , Fungi/drug effects , HeLa Cells/drug effects , Lethal Dose 50 , Magnetic Resonance Spectroscopy , Mass Spectrometry , Mice , Microbial Sensitivity Tests , Nigericin/analogs & derivatives , Nigericin/isolation & purification , Nigericin/pharmacology , Spectrophotometry, Infrared , Streptomyces griseus/metabolismABSTRACT
Grisorixin, a polycyclic polyether antibiotic of the nigericin group, showed ionophorous properties. The conformations of crystallized grisorixin and its metallic salts are very similar and are compared in this paper. The physico-chemical properties of the salts are described. The chemical oxidation of grisorixin methyl ester allowed us to isolate several oxidation products whose structures are described.