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1.
Pediatr Blood Cancer ; 67(10): e28621, 2020 10.
Article in English | MEDLINE | ID: mdl-32729194

ABSTRACT

Sertoli-Leydig cell tumors (SLCTs) are rare ovarian neoplasms in pediatric patients. More exceedingly rare are SLCTs that also contain heterologous rhabdomyosarcoma (RMS) elements. For these patients, there is no standardized treatment. We report four cases of pediatric SLCT with heterologous RMS elements that were successfully treated with surgical resection and adjuvant chemotherapy. All four patients are alive and remain in remission.


Subject(s)
Ovarian Neoplasms/pathology , Rhabdomyosarcoma, Embryonal/pathology , Sertoli-Leydig Cell Tumor/pathology , Adolescent , Combined Modality Therapy , Female , Follow-Up Studies , Humans , Ovarian Neoplasms/therapy , Prognosis , Retrospective Studies , Rhabdomyosarcoma, Embryonal/therapy , Sertoli-Leydig Cell Tumor/therapy
2.
Blood Cells Mol Dis ; 61: 4-9, 2016 10.
Article in English | MEDLINE | ID: mdl-27667160

ABSTRACT

Hereditary elliptocytosis (HE) and hereditary pyropoikilocytosis (HPP) are heterogeneous red blood cell (RBC) membrane disorders that result from mutations in the genes encoding α-spectrin (SPTA1), ß-spectrin (SPTB), or protein 4.1R (EPB41). The resulting defects alter the horizontal cytoskeletal associations and affect RBC membrane stability and deformability causing shortened RBC survival. The clinical diagnosis of HE and HPP relies on identifying characteristic RBC morphology on peripheral blood smear and specific membrane biomechanical properties using osmotic gradient ektacytometry. However, this phenotypic diagnosis may not be readily available in patients requiring frequent transfusions, and does not predict disease course or severity. Using Next-Generation sequencing, we identified the causative genetic mutations in fifteen patients with clinically suspected HE or HPP and correlated the identified mutations with the clinical phenotype and ektacytometry profile. In addition to identifying three novel mutations, gene sequencing confirmed and, when the RBC morphology was not evaluable, identified the diagnosis. Moreover, genotypic differences justified the phenotypic differences within families with HE/HPP.


Subject(s)
Elliptocytosis, Hereditary/genetics , Genetic Association Studies , Adolescent , Child , Child, Preschool , Cytoskeletal Proteins/genetics , DNA Mutational Analysis , Erythrocyte Membrane/chemistry , Erythrocyte Membrane/ultrastructure , Female , Humans , Infant , Male , Medical History Taking , Membrane Proteins/genetics , Mutation , Pedigree , Spectrin/genetics
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