A Multi-Method Approach to Addressing the Toddler Data Desert in Attention Research.

Visual attention skills undergo robust development change during infancy and continue to co-develop with other cognitive processes in early childhood. Despite this, this is a general disconnect between measures of the earliest foundations of attention during infancy and later development of attention in relation to executive functioning during the toddler years. To examine associations between these different measures of attention, the current study administered an oculomotor task (infant orienting with attention, IOWA) and a manual response (Flanker) task with a group of toddlers. We collected simultaneous neural recordings (using functional near-infrared spectroscopy), eye-tracking, and behavioral responses in 2.5- and 3.5-year-olds to examine the neural and behavioral associations between these skills. Results revealed that oculomotor facilitation in the IOWA task was negatively associated with accuracy on neutral trials in the Flanker task. Second, conflict scores between the two tasks were positively associated. At the neural level, however, the tasks showed distinct patterns of activation. Left frontal cortex was engaged during the Flanker task whereas right frontal and parietal cortex was engaged during the IOWA task. Activation during the IOWA task differed based on how well children could control oculomotor behavior during the task. Children with high levels of stimulus reactivity activated parietal cortex more strongly, but children with more controlled oculomotor behavior activated frontal cortex more strongly.

Assessing the relationship between maternal risk for attention deficit hyperactivity disorder and functional connectivity in their biological toddlers.

BACKGROUND: Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder associated with increased risk for poor educational attainment and compromised social integration. Currently, clinical diagnosis rarely occurs before school-age, despite behavioral signs of ADHD in very early childhood. There is no known brain biomarker for ADHD risk in children ages 2-3 years-old. METHODS: The current study aimed to investigate the functional connectivity (FC) associated with ADHD risk in 70 children aged 2.5 and 3.5 years via functional near-infrared spectroscopy (fNIRS) in bilateral frontal and parietal cortices; regions involved in attentional and goal-directed cognition. Children were instructed to passively watch videos for approximately 5 min. Risk for ADHD in each child was assessed via maternal symptoms of ADHD, and brain data was evaluated for FC. RESULTS: Higher risk for maternal ADHD was associated with lower FC in a left-sided parieto-frontal network. Further, the interaction between sex and risk for ADHD was significant, where FC reduction in a widespread bilateral parieto-frontal network was associated with higher risk in male, but not female, participants. CONCLUSIONS: These findings suggest functional organization differences in the parietal-frontal network in toddlers at risk for ADHD; potentially advancing the understanding of the neural mechanisms underlying the development of ADHD.

To snack or not to snack: Using fNIRS to link inhibitory control to functional connectivity in the toddler brain.

Inhibitory control (IC) emerges in infancy, continues to develop throughout childhood and is linked to later life outcomes such as school achievement, prosocial behavior, and psychopathology. Little, however, is known about the neural processes underpinning IC, especially in 2-year-olds. In this study, we examine functional connectivity (FC) in 2.5-year-olds while recording hemodynamic responses via functional infrared spectroscopy (fNIRS) during a traditional snack delay task. We found that functional connectivity strength between left frontal and parietal cortex and bilateral parietal cortex were positively associated with performance on this task. The current findings present the first neural data for toddlers during this IC task. Further, these data are the first to link this self-regulatory process to differences in brain development within this population. Implications for future directions and work with clinical populations are discussed.

Exploring the neural basis of selective and flexible dimensional attention: An fNIRS study.

Between the ages of 3 and 5, children develop greater control over attention to visual dimensions. Children develop the ability to flexibly shift between visual dimensions and to selectively process specific dimensions of an object. Previous proposals have suggested that selective and flexible attention are developmentally related to one another (e.g., Hanania & Smith, 2010). However, the relationship between flexibility and selectivity has not been systematically probed at the behavioral and neural levels. We administered a selective attention task (triad classification) along with a flexible attention task (dimensional change card sort) with 3.5- and 4.5-year-olds while functional near-infrared spectroscopy data were recorded. Results showed that children with high flexible attention skills engaged bilateral frontal cortex which replicates previous studies using this task. Moreover, children with high levels of selective attention engaged right frontal cortex. Together, these results indicate that development in right frontal cortex is important for both flexible and selective dimensional attention.

Dimensional attention as a mechanism of executive function: Integrating flexibility, selectivity, and stability.

In this report, we present a neural process model that explains visual dimensional attention and changes in visual dimensional attention over development. The model is composed of an object representation system that binds visual features such as shape and color to spatial locations and a label learning system that associates labels such as "color" or "shape" with visual features. We have previously demonstrated that this model explains the development of flexible dimensional attention in a task that requires children to switch between shape and color rules for sorting cards. In the model, the development of flexible dimensional attention is a product of strengthening associations between labels and features. In this report, we generalize this model to also explain development of stable and selective dimensional attention. Specifically, we use the model to explain a previously reported developmental association between flexible dimensional attention and stable dimensional attention. Moreover, we generate predictions regarding developmental associations between flexible and selective dimensional attention. Results from an experiment with 3- and 4-year-olds supported model predictions: children who demonstrated flexibility also demonstrated higher levels of selectivity. Thus, the model provides a framework that integrates various functions of dimensional attention, including implicit and explicit functions, over development. This model also provides new avenues of research aimed at uncovering how cognitive functions such as dimensional attention emerge from the interaction between neural dynamics and task structure, as well as understanding how learning dimensional labels creates changes in dimensional attention, brain activation, and neural connectivity.

Investigating the role of temporal lobe activation in speech perception accuracy with normal hearing adults: An event-related fNIRS study.

Functional near infrared spectroscopy (fNIRS) is a safe, non-invasive, relatively quiet imaging technique that is tolerant of movement artifact making it uniquely ideal for the assessment of hearing mechanisms. Previous research demonstrates the capacity for fNIRS to detect cortical changes to varying speech intelligibility, revealing a positive relationship between cortical activation amplitude and speech perception score. In the present study, we use an event-related design to investigate the hemodynamic response in the temporal lobe across different listening conditions. We presented participants with a speech recognition task using sentences in quiet, sentences in noise, and vocoded sentences. Hemodynamic responses were examined across conditions and then compared when speech perception was accurate compared to when speech perception was inaccurate in the context of noisy speech. Repeated measures, two-way ANOVAs revealed that the speech in noise condition (-2.8dB signal-to-noise ratio/SNR) demonstrated significantly greater activation than the easier listening conditions on multiple channels bilaterally. Further analyses comparing correct recognition trials to incorrect recognition trials (during the presentation phase of the trial) revealed that activation was significantly greater during correct trials. Lastly, during the repetition phase of the trial, where participants correctly repeated the sentence, the hemodynamic response demonstrated significantly higher deoxyhemoglobin than oxyhemoglobin, indicating a difference between the effects of perception and production on the cortical response. Using fNIRS, the present study adds meaningful evidence to the body of knowledge that describes the brain/behavior relationship related to speech perception.