ABSTRACT
PURPOSE: The purpose of the study was to determine the prevalence of fractures and incidental findings (IF) with emphasis on clinical significance. MATERIALS AND METHODS: A total of 784 patients were evaluated by computed tomography. Fractures and IF were registered and classified as significant if they were recommended for additional diagnostics or therapy. RESULTS: Four hundred seventy of 784 patients (60%) sustained a fracture. Significant fractures were found in 694/1213 fractures (57%); nonsignificant fractures were found in 519/1213 (43%) fractures. A total of 972 IF were observed in 464/784 (59%) patients. Significant findings were found in 358/972 findings (37%). There were 1.5 fractures and 1.2 IF per patient. CONCLUSION: There is a high prevalence of significant fractures (57%) and IF (37%).
Subject(s)
Facial Bones/diagnostic imaging , Facial Bones/injuries , Facial Injuries/diagnostic imaging , Facial Injuries/epidemiology , Fractures, Bone/diagnostic imaging , Fractures, Bone/epidemiology , Multidetector Computed Tomography , Accidental Falls/statistics & numerical data , Accidents/statistics & numerical data , Accidents, Traffic/statistics & numerical data , Adolescent , Adult , Age Distribution , Aged , Aged, 80 and over , Brain Diseases/epidemiology , Brain Neoplasms/epidemiology , Causality , Cerebrovascular Disorders/epidemiology , Child , Child, Preschool , Comorbidity , Female , Humans , Incidental Findings , Male , Middle Aged , Prevalence , Retrospective Studies , Sex Distribution , Violence/statistics & numerical data , Young AdultSubject(s)
Heart Neoplasms/diagnosis , Lymphoma, Large B-Cell, Diffuse/diagnosis , Magnetic Resonance Imaging , Antibodies, Monoclonal, Murine-Derived/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/administration & dosage , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Biopsy , Cyclophosphamide/administration & dosage , Doxorubicin/administration & dosage , Heart Neoplasms/complications , Heart Neoplasms/diagnostic imaging , Heart Neoplasms/drug therapy , Heart Neoplasms/pathology , Humans , Lymphoma, Large B-Cell, Diffuse/complications , Lymphoma, Large B-Cell, Diffuse/diagnostic imaging , Lymphoma, Large B-Cell, Diffuse/drug therapy , Lymphoma, Large B-Cell, Diffuse/pathology , Male , Middle Aged , Prednisone/administration & dosage , Remission Induction , Rituximab , Sepsis/complications , Ultrasonography , Ventricular Fibrillation/etiology , Vincristine/administration & dosageSubject(s)
Aortic Aneurysm/diagnostic imaging , Aortic Diseases/diagnostic imaging , Aortic Dissection/diagnostic imaging , Hematoma/diagnostic imaging , Aged , Aortic Dissection/surgery , Aorta/pathology , Aortic Aneurysm/surgery , Aortic Diseases/surgery , Blood Vessel Prosthesis , Chest Pain/etiology , Echocardiography , Hematoma/surgery , Humans , Male , Tomography, X-Ray Computed , Tunica Intima/pathologyABSTRACT
BACKGROUND: Decreased levels of circulating bone marrow-derived progenitor cells have been associated with risk factors and cardiovascular diseases. Smoking is the most important modifiable risk factor for atherosclerosis in young women. The aim of this pilot study was to assess in healthy premenopausal women without other risk factors for cardiovascular disease the influence of nicotine abuse on the number of circulating progenitor cells in relation to endothelial function. METHODS: The number of endothelial progenitor cells, measured as colony-forming units in a cell-culture assay (EPC-CFU) and the number of circulating CD34 + and CD34 + /CD133 + cells, measured by flow cytometry, was estimated in 32 women at the menstrual phase of the menstrual cycle. In addition, flow-mediated dilation (FMD) was assessed as a marker for vascular function. In a subgroup of these women (n = 20), progenitor cells were also investigated at the mid-follicular and luteal phases of the menstrual cycle. RESULTS: Compared to non-smokers, the abundance of circulating CD34 + cells was significantly lower in smoking women in the menstrual, mid-luteal, and mid-follicular phases of the menstrual cycle. The number of CD34 + progenitor cells was revealed to have significant positive correlation with FMD in young healthy women, whereas CD34 + /CD133 + progenitor cells and EPC-CFU showed no significant correlation. CONCLUSION: The number of CD34 + progenitor cells positively correlates with FMD in young healthy women and is decreased by smoking.
