Subject(s)
Cushing Syndrome/metabolism , Electrolytes/metabolism , Adolescent , Adult , Child , Cushing Syndrome/surgery , Female , Humans , Male , Middle AgedABSTRACT
The authors carried out a lymphographic examination in 11 patients with various diseases of the thyroid gland. Lymphography proved to be an effective and harmless diagnostic method in pathological changes of the thyroid gland. Different structure of the thyroid gland tissue was revealed on the lymphograms depending on the character of the pathological process. In establishment of the diagnosis one should take into consideration the structure of the thyroid gland tissue, the structure of the cervical lymph nodes, and possibilities of their filling with the contrast agent, the amount, the rate and difficulties encountered in the administration of the contrast substance.
Subject(s)
Lymphography , Thyroid Diseases/diagnostic imaging , Thyroid Gland/diagnostic imaging , Adolescent , Adult , Diagnosis, Differential , Female , Goiter, Nodular/diagnostic imaging , Humans , Male , Middle Aged , Thyroid Neoplasms/diagnostic imaging , Thyroiditis/diagnostic imagingABSTRACT
The results of examination of ECG in 44 patients suffering from Itsenko-Cushing's disease at different stages of surgical treatment are presented. The data obtained were compared with the blood potassium and sodium levels, 17-KS, and 17-OCS levels in the urine, arterial pressure and cholesterol content. Various ECG changes before the operation were revealed in 39 patients. Signs of enlargement of the left ventricle and deformity of the end part of the ventricular complex (negative T wave and or reduction of S-T segment in I, II, avL V5-6 leads) were found in 8 patients, and deformity of the end part of the ventricular complex without any signs of enlargement of the left ventricle--in 18 patients. There proved to be a significant dependence of the changes in the end port of the ventricular complex on increased urinary excretion of 17-OCS, hypokaliemia and hypernatriemia. Negative ECG changes after bilateral total adrenalectomy was significantly connected with postoperative hypocorticism.
Subject(s)
Adrenalectomy , Cushing Syndrome/surgery , Heart/physiopathology , 17-Hydroxycorticosteroids/urine , 17-Ketosteroids/urine , Adrenal Glands/physiopathology , Adrenal Insufficiency/physiopathology , Adrenalectomy/adverse effects , Adult , Cholesterol/blood , Cushing Syndrome/metabolism , Cushing Syndrome/physiopathology , Electrocardiography , Erythrocytes/analysis , Humans , Middle Aged , Potassium/blood , Sodium/bloodABSTRACT
A study was made of the capacity of insulinoma to catalyze the splitting of hippuryl-L-arginine (HA) and the contents of proinsulin-like component in the tissues of the tumours and in the blood serum of the patients. As revealed, in the absence of HA splitting by the tumour cytoplasmic fraction in the neutral pH zone there was noted a higher proinsulin-like component both in the tumour tissue and in the blood serum. An increase amount of proinsulin-like component in the blood serum stipulates possibly a more prolonged period of starvation before the occurrence of hypoglycemia, and a less pronounced picture of hypoglycemia in such patients in comparison with the patients whose tumours were capable of splitting HA similarly to the normal islands of Langerhans.
Subject(s)
Adenoma, Islet Cell/complications , Hypoglycemia/etiology , Pancreatic Neoplasms/complications , Adenoma, Islet Cell/enzymology , Arginine/analogs & derivatives , Arginine/metabolism , Blood Glucose/analysis , Carboxypeptidases/metabolism , Clinical Trials as Topic , Cytoplasm/enzymology , Fasting , Hippurates/metabolism , Humans , Hypoglycemia/enzymology , Insulin/biosynthesis , Pancreatic Neoplasms/enzymology , Proinsulin/metabolism , Time FactorsABSTRACT
The authors present the results of study of the state of the water-electrolyte metabolism at the early postoperative period in 58 patients suffering from Itsenko-Cushing's disease with consideration of the potassium deficiency correction. Potassium and sodium level was studied in the plasma and the erythrocytes. Besides, in 31 patients potassium and sodium content were examined in the muscular tissue obtained during the operation. Hypoglycemia was revealed in 48.2% of the cases, and hypernatriemia--in 19.0%. A reduction of potassium level in the erythrocytes was revealed in 50%, and a rise of sodium--in 52% of cases. The muscle tissue potassium level fell in parallel to the reduction of this electrolyte level in the erythrocytes. Disturbances of the electrolyte balance proved to be most pronounced at the early postoperative period in the patients given no potassium preparations. Separate use of potassium preparations, or (particularly) together with veroshpiron, prevented potassium deficiency at the early postoperative period.
