ABSTRACT
Therapeutic and prophylactic antiarrhythmic efficacy of sotalol hydrochloride (Sotahexal, "Hexal", Germany) and its effects in intracardiac hemodynamics and ECG parameters were evaluated in 95 patients with ischemic heart disease (IHD). The highest response to the drug was observed in ventricular extrasystoles, arterial flutter and fibrillation. Acute episodes of arrhythmia are managed by bolus administration of Sotahexal [correction of Hexal]. In this case greater risk of side effects exists. It is desirable to decide on the drug dose, mode of administration on the individual basis with due consideration of the risks and dangers which could be avoided in case of adequate instrumental control.
Subject(s)
Adrenergic beta-Antagonists/pharmacology , Anti-Arrhythmia Agents/pharmacology , Myocardial Ischemia/drug therapy , Sotalol/pharmacology , Adrenergic beta-Antagonists/administration & dosage , Adrenergic beta-Antagonists/adverse effects , Adult , Aged , Aged, 80 and over , Animals , Anti-Arrhythmia Agents/administration & dosage , Anti-Arrhythmia Agents/adverse effects , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/prevention & control , Cats , Dogs , Drug Evaluation, Preclinical , Female , Hemodynamics/drug effects , Humans , Infusions, Intravenous , Male , Middle Aged , Myocardial Ischemia/complications , Myocardial Ischemia/physiopathology , Sotalol/administration & dosage , Sotalol/adverse effects , TabletsSubject(s)
Anti-Arrhythmia Agents/therapeutic use , Arrhythmias, Cardiac/drug therapy , Coronary Disease/drug therapy , Dibenzazepines/therapeutic use , Aged , Arrhythmias, Cardiac/etiology , Arrhythmias, Cardiac/physiopathology , Coronary Disease/complications , Coronary Disease/physiopathology , Female , Heart Conduction System/drug effects , Heart Conduction System/physiopathology , Hemodynamics/drug effects , Hemodynamics/physiology , Humans , Male , Middle Aged , TabletsABSTRACT
A trial of the antiarrhythmic drug ethacizine made in the Soviet Union which is an analogue of ethmozine was performed in 38 patients suffering from coronary heart disease. Automatism, conduction and excitation of the myocardium, hemodynamics and the antiarrhythmic effect were studied using electrophysiological methods, echo-cardiography and Holter monitoring. Ethacizine was found effective in arrhythmia. It reduces conduction in small changes of hemodynamics and myocardial contractility.
