[Free-radical mechanism of antimicrobial action of xanthine oxidase and lactoperoxidase]. / Svobodno-radikal'nyi mekhanizm antimikrobnogo deistviia ksantinoksidazy i laktoperoksidazy.

The interaction between milk xanthine oxidase (XO) and lactoperoxidase (LP) in model system and antimicrobial action of these enzymes on Escherichia coli 0-111 were studied. It was shown, that bacterial superoxide dismutase (SOD), which transforms O2-. (XO-reaction product) into H2O2 (substrate of LP), is necessary for binding of the reaction sequence: XO-->LP-->antimicrobial products. It is suggested, that these enzymes unite in the protective system in intestinal infections of newborns. Bacterial SOD in this case acts as the key factor, creating the system.