ABSTRACT
Several 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadiazole and their dihydro analogues were synthesized from hetero aromatic acids and hetero aromatic aldehydes, respectively, by microwave-assisted dry media and conventional methods. Elemental analysis, IR, (1)H NMR, (13)C NMR and mass spectral data elucidated the structures of all newly synthesized compounds. Synthesized compounds are studied for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed significant pharmacological activities.
Subject(s)
Thiadiazoles/chemistry , Thiadiazoles/pharmacology , Analgesics/chemistry , Analgesics/pharmacology , Animals , Anti-Bacterial Agents/chemistry , Anti-Bacterial Agents/pharmacology , Anti-Inflammatory Agents, Non-Steroidal/chemistry , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Female , Fungi/drug effects , Male , Mice , Molecular Structure , Rats , Rats, Wistar , Structure-Activity RelationshipABSTRACT
Several 3,6-disubstituted-1,2,4-triazolo[3,4-b]-1,3,4-thiadizoles were prepared by the condensation of 4-amino-3-aryl/aralkyl substituted-5-mercapto-1,2,4-triazoles 3(a-c) with various substituted aromatic/hetero aromatic acids through a single step reaction. Elemental analysis, IR, 1H NMR and mass spectral data confirmed the structure of the newly synthesized compounds. Synthesized triazolo thiadiazoles investigated for their antibacterial, antifungal, anti-inflammatory and analgesic activities. Some of the tested compounds showed moderate antimicrobial activity against various tested bacterial and fungal strains. None of the synthesized compounds have significant anti-inflammatory and analgesic activities.
Subject(s)
Analgesics/pharmacology , Anti-Bacterial Agents/pharmacology , Anti-Inflammatory Agents/pharmacology , Antifungal Agents/pharmacology , Nitrogen/chemistry , Thiadiazoles/chemical synthesis , Thiadiazoles/pharmacology , Analgesics/chemical synthesis , Analgesics/chemistry , Animals , Anti-Bacterial Agents/chemical synthesis , Anti-Bacterial Agents/chemistry , Anti-Inflammatory Agents/chemical synthesis , Anti-Inflammatory Agents/chemistry , Antifungal Agents/chemical synthesis , Antifungal Agents/chemistry , Female , Male , Molecular Structure , Rats , Rats, Wistar , Structure-Activity Relationship , Thiadiazoles/chemistryABSTRACT
The synthesis of iron(III) complexes of general formula FeCl(R-pc), where R-pc are dianionic, symmetrically halogen substituted phthalocyanines at the positions 2,9,16,23 or 1,8,15,22, from the corresponding amino substituted derivatives is described (R=Cl, Br, I). The complexes are characterized by UV-visible and infrared spectra, powder X-ray diffraction and magnetic susceptibility measurements. The effect of substituents at the periphery and the basicity of the solvents used on the electronic spectra are discussed. The Q band of the electronic spectra for symmetrically halogen substituted derivatives are redshifted and the substituents at 2,9,16,23- positions are more effective in redshifting the Q bands than those at 1,8,15,22-positions. Depending upon the basicity of the solvents, the ligand-to-metal charge transfer (LMCT) transitions on Q band envelop shift to the higher energy region in the order of pyridine>DMF>DMSO. The infrared absorption signals for C-H and metal-ligand vibrations appear to be sharper for 1,8,15,22 substituted derivatives than for 2,9,16,23 substituted ones.