Lung T1 MRI assessments in children with mild cystic fibrosis lung disease.

RATIONALE: Lung T1 MRI is a potential method to assess cystic fibrosis (CF) lung disease that is safe, quick, and widely available, but there are no data in children with mild CF lung disease. OBJECTIVE: Assess the ability of lung T1 MRI to detect abnormalities in children with mild CF lung disease. METHODS: We performed T1 MRI, multiple breath washout (MBW), chest computed tomography (CT), and spirometry in a cohort of 45 children with mild CF lung disease (6-11 years of age). MAIN RESULTS: Despite mean normal ppFEV1 values, the majority of children with CF in this study exhibited mild lung disease evident in lung clearance index (LCI) measured by MBW, chest CT Brody scores, and percent normal lung perfusion (%NLP) measured by T1 MRI. The %NLP correlated with chest CT Brody scores, as did LCI, but %NLP and LCI did not correlate with each other. Analysis of the Brody subscores showed that %NLP and LCI largely correlated with different Brody subscores. CONCLUSIONS: T1 MRI can detect mild CF lung disease in children and correlates with chest CT findings. The %NLP from T1 MRI and LCI correlate with different chest CT Brody subscores, suggesting they provide complementary information about CF lung disease.

Nonreciprocal Fabry-Perot effect and performance enhancement in a magneto-optical InSb-based Faraday terahertz isolator.

The Faraday effect due to the cyclotron resonance of conduction electrons in semiconductor InSb allows for nonreciprocity of transmitted light in our Faraday THz isolator operating in the presence of a small magnetic field. We select InSb as an efficient medium for our isolator due to its high electron mobility, low electron effective mass, and narrow band gap. Experimental measurements of the isolator performance indicate a maximum achieved isolation power of 18.8 dB with an insertion loss of -12.6 dB. Our optical analysis of the device points to a remarkable nonreciprocal Fabry-Perot effect in the magneto-optical InSb layer as the origin of the multi-fold isolation enhancement. This nonreciprocity occurs as the Fabry-Perot reflections in the forward direction add constructively and enhance the transmittance at certain frequencies, while the Fabry-Perot reflections in the backward direction add destructively and suppress the transmittance at the same frequencies.