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1.
Allergy ; 69(4): 541-4, 2014 Apr.
Article in English | MEDLINE | ID: mdl-24697338

ABSTRACT

Epidemiologic studies suggest that dietary vitamin E is a candidate intervention for atopic disease. We used in vitro and ex vivo exposures to test the hypothesis that the most common dietary isoform of vitamin E, γ-tocopherol (γT), could suppress FcεRI-mediated basophil activation. Rat basophilic leukemia (RBL)-SX38 cells that express human FcεRI were treated with or without γT, followed by stimulation with α-IgE. In the ex vivo study, 20 Der f 1-allergic volunteers consumed a γT-enriched supplement for 7 days. Their basophils were challenged ex vivo with α-IgE and graded doses of Der f 1 before and after the supplementation period. γt treatment of RBL-SX38 cells significantly reduced basophil degranulation and de novo TH2 cytokine production. Daily consumption of a γT-rich supplement by dust mite-allergic volunteers reduced basophil activation after ex vivo dust mite challenge. Vitamin E supplements rich in γT may be useful adjuncts in decreasing atopic disease.


Subject(s)
Antigens, Dermatophagoides/immunology , Basophils/drug effects , Basophils/immunology , Vitamin E/pharmacology , gamma-Tocopherol/pharmacology , Cell Degranulation/drug effects , Cell Degranulation/immunology , Cell Line , Cytokines/biosynthesis , Humans , Immunoglobulin E/immunology , Leukotriene D4/metabolism
2.
Eur J Neurol ; 16(9): 1060-5, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19469836

ABSTRACT

BACKGROUND AND PURPOSE: The aim of this hospital-based survey was to determine baseline stroke knowledge in Croatian population attending the outpatient services at the Department of Neurology. METHODS: A multiple choice questionnaire was designed, divided into three sections: (i) demographic data, (ii) knowledge of stroke risk factors and stroke signs and (iii) actions the patients would undertake if confronted with risk of stroke and information resources regarding health. RESULTS: The analysis included 720 respondents (54.9% women). The respondents most frequently indicated stroke symptoms as following: speech disorder 82%, paresthesiae on one side of the body 71%, weakness of arm or leg 55%, unsteady gait 55%, malaise 53%, monocular loss of vision 44%. The risk factors most frequently identified were hypertension 64%, stress 61%, smoking 59%, elevated lipids 53%, obesity 52%, coagulation disorder 47%, alcoholism 45%, low-physical activity 42%, elderly age 39%, cardiac diseases 38%, weather changes 34%, drugs 33% and diabetes 32%. If confronted with stroke signs 37% of respondents would consult the general practitioner and 31% would call 911 or go to a neurologist. Amongst patients with a risk factor, only diabetics were aware that their risk factor might cause stroke (P < 0.001). Respondents with lowest education had the least knowledge regarding stroke signs (P < 0.01). DISCUSSION: The results of this study indicate that respondents showed a fair knowledge about stroke signs and risk factors for stroke. The results of our study will help to create and plan programmes for improvement of public health in Croatia.


Subject(s)
Health Knowledge, Attitudes, Practice , Outpatients , Stroke/etiology , Adolescent , Adult , Aged , Aged, 80 and over , Croatia , Educational Status , Female , Health Surveys , Humans , Male , Middle Aged , Risk Factors , Socioeconomic Factors , Stroke/physiopathology , Surveys and Questionnaires
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