ABSTRACT
Our aim was to investigate the effect of sclerosant agent OK-432 on tongue fibrosis and to determine whether the fibrosis formed by this substance increases with dose. Fifty Wistar albino rats were divided into three groups for the study. In the first group 0.2 ml OK-432, in the second group 0.5 ml OK-432, and in the third group physiological saline as the control substance was injected into the tongue of these rats. Subjects were sacrificed on the first day, first week, first month, third month and sixth month following the injection. Cross-sections of the tongues were stained with hematoxylin-eosin (HE) and Masson Tri-chrome. The degree of fibrosis was measured using ocular micrometry. A significant amount of fibrosis was observed in both the 0.2 ml (P = 0.020) and 0.5 ml (P = 0.003) OK-432 injection groups. OK-432 is a material that causes significant fibrosis in the muscle when compared to physiological saline. The degree of fibrosis in the tongue increases with dose.
Subject(s)
Fibrosis/drug therapy , Picibanil/pharmacology , Picibanil/therapeutic use , Sclerosing Solutions/pharmacology , Sclerosing Solutions/therapeutic use , Snoring/surgery , Tongue Diseases/drug therapy , Animals , Disease Models, Animal , Fibrosis/pathology , Injections , Male , Mouth Mucosa/drug effects , Picibanil/administration & dosage , Rats , Rats, Wistar , Sclerosing Solutions/administration & dosage , Sleep Apnea, Obstructive/drug therapy , Tongue Diseases/pathologyABSTRACT
Rhinosporidiosis is a chronic granulomatous inflammatory disease of the mucous membranes caused by Rhinosporidium seeberi. The disease is endemic in India, but is very rare in other countries. A review of the literature shows that our patient is the second documented case from Turkey. Involvement and erosion of the anterior wall of the maxillary sinus as in this case is very rare. A 47-year-old-male is presented with the clinicopathological features and transmission of the disease is discussed.
