1.
J Org Chem
; 80(8): 3965-73, 2015 Apr 17.
Article
in English
| MEDLINE
| ID: mdl-25826147
ABSTRACT
The syntheses of all possible stereoisomers of desfluorinated side products of the potent antihypertensive ß-blocker nebivolol are reported. A straightforward approach using a common racemic precursor was employed to obtain the desired optically active building blocks. For one series of compounds, a Sharpless asymmetric epoxidation (SAE) route yielded in a direct fashion the required compounds whereas a Mitsunobu reaction was selected to obtain the other series of compounds. This offers a flexible approach to all desfluoronebivolol side-products in order to fully characterize them.