1.
Infection
; 35(4): 271-4, 2007 Jun.
Article
in English
| MEDLINE
| ID: mdl-17646913
ABSTRACT
Methicillin-resistant Staphylococcus aureus (MRSA) is increasing in prevalence both in nosocomial and in community settings. Treatment of such infections, particularly in the central nervous system (CNS), is problematic, as available options are limited. Linezolid is a new antibiotic with activity against Gram-positive cocci, including MRSA, and has good penetration into the cerebrospinal fluid. To our knowledge, there are only three case reports of successful treatment of CNS infections caused by MRSA with linezolid; we report herein a fourth such case. Clinical trials to address the role of linezolid in CNS infections are urgently needed.
Subject(s)
Acetamides/administration & dosage , Anti-Bacterial Agents/administration & dosage , Meningitis, Bacterial/drug therapy , Methicillin Resistance/drug effects , Oxazolidinones/administration & dosage , Staphylococcal Infections/drug therapy , Staphylococcus aureus/drug effects , Anesthesia, Epidural/adverse effects , Cross Infection/drug therapy , Cross Infection/etiology , Drug Resistance, Multiple, Bacterial/drug effects , Female , Humans , Infusions, Intravenous , Linezolid , Middle Aged
2.
Infection
; 32(2): 122-3, 2004 Apr.
Article
in English
| MEDLINE
| ID: mdl-15057579
Subject(s)
Pasteurella Infections/diagnosis , Pasteurella multocida/isolation & purification , Peripheral Vascular Diseases/surgery , Surgical Wound Infection/microbiology , Vascular Surgical Procedures/adverse effects , Aged , Anti-Bacterial Agents/therapeutic use , Female , Humans , Pasteurella Infections/drug therapy , Peripheral Vascular Diseases/diagnosis , Rare Diseases , Risk Assessment , Severity of Illness Index , Surgical Wound Infection/drug therapy , Tissue Transplantation/adverse effects , Treatment Outcome , Vascular Surgical Procedures/methods
3.
N Engl J Med
; 345(23): e5, 2001 Dec 06.
Article
in English
| MEDLINE
| ID: mdl-11759661
